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Repeat Expansions in PLIN4 Cause Autosomal Dominant Vacuolar Myopathy With Sarcolemmal Features
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective We aim to describe and characterize two unrelated Spanish families suffering from an autosomal dominant autophagic vacuolar myopathy caused by repeat expansions in PLIN4. Methods We evaluated the clinical phenotype and muscle imaging, and performed a genetic workup that included exome sequencing, muscle RNAseq, and long‐read genome ...
Laura Llansó +17 more
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Cellular Models of Trophoblast Differentiation [PDF]
Seminars in Reproductive Medicine, 2016 Orchestrated trophoblast differentiation is necessary to establish and maintain a normal pregnancy, however the molecular mechanisms that guide this process remain largely unknown. Although early studies of cytotrophoblast differentiation relied on animal models, more recent trophoblast research has involved in vitro models of human tissue.
Marissa L. Steinberg, Jared C. Robins
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Cellular features of differentiation in the nail
Microscopy Research and Technique, 1997Biochemical analysis indicated that the human nail plate contains two distinct types of keratin (skin-type and hair-type keratins), and several population of keratinocytes are thought to be associated with development of the nail. To elucidate the nature of the differentiation occurring in nail development, we examined the patterns of molecular markers
Hideoki Ogawa, Takashi Kitahara
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Embryogenesis and Cellular Differentiation
2018Embryonic development is a tightly regulated process that produces from a single zygote the some 400 different tissues and cell types forming the human body. The differentiation program of embryogenesis is under the control of transcription factor networks in the context of significant changes in the epigenetic landscape.
Ferdinand Molnár, Carsten Carlberg
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Hypoxia, pseudohypoxia and cellular differentiation
Experimental Cell Research, 2017Tumor hypoxia correlates to aggressive disease, and while this is explained by a variety of factors, one clue to understand this phenomena was the finding that hypoxia induces a de-differentiated, stem cell-like phenotype in neuroblastoma and breast tumor cells. The hypoxia inducible transcription factors (HIFs) are regulated at the translational level
Caroline Wigerup +3 more
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Cellular Differentiation and Morphogenesis
1988One of the major aims of this book is to appraise critically the role that PGRs play in plant development. Certain developmental phenomena which have been reported to be influenced by PGRs, such as juvenility, vernalization and the photoperiodic induction of flowering, involve the transition of shoot apices from one state of differentiation to another.
Richard Hooley, Jeremy A. Roberts
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Cellular neurothekeoma with histiocytic differentiation
Journal of Cutaneous Pathology, 2004Background: It is generally accepted that the two types of neurothekeoma (myxoid type and cellular type) represent the two poles of a spectrum. This concept, however, has recently been challenged, and cellular neurothekeomas have been suggested as a separate classification and are included in the ‘fibrohistiocytic’ category by some authors.
Yutaka Narisawa +2 more
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The effect of interferons on cellular differentiation
Blut, 1986The influence of IFN on cellular differentiation is well established in a variety of in vitro models such as Friend erythroleukemia, HL-60 cells or monocyte-macrophage differentiation. The exact effect of interferon, however, differs in special experimental situations.
Holger Kirchner, T. Moritz
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