Results 41 to 50 of about 1,459,173 (350)

TINCR, staufen1, and cellular differentiation [PDF]

RNA Biology, 2013
The human genome encodes several thousand long non-protein coding transcripts>200 nucleotides in length, a subset of which were shown to play important roles in regulation of gene expression. We recently identified TINCR, a lncRNA required for induction of key differentiation genes in epidermal tissue, including genes mutated in human skin diseases ...
openaire   +3 more sources

Comparative Analysis of Nuclear Transfer Embryo Derived Mouse Embryonic Stem Cells. Part I: Cellular characterization [PDF]

, 2012
Embryonic stem cells derived from nuclear transfer embryos (ntESCs) are particularly valuable for regenerative medicine, as they are a patient-specific and histocompatible cell source for the treatment of varying diseases.
Csonka, Erika, Dinnyes, Andras, Hadlaczky, Gyula, Kobolak, Julianna, Mamo, Solomon, Rungsiwiwut, Ruttachuk, Ujhelly, Olga   +6 more
core   +1 more source

The dual nature of TDC – bridging dendritic and T cells in immunity

FEBS Letters, EarlyView.
TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley   +1 more source

Cellular mechanisms linking to outdoor and indoor air pollution damage during pregnancy

Frontiers in Endocrinology, 2023
Pregnancies are a critical window period for environmental influences over the mother and the offspring. There is a growing body of evidence associating indoor and outdoor air pollution exposure to adverse pregnancy outcomes such as preterm birth and ...
Delia I. Chiarello, Javier Ustáriz, Reinaldo Marín, Ivo Carrasco-Wong, Marcelo Farías, Ady Giordano, Felipe S. Gallardo, Sebastián E. Illanes, Sebastián E. Illanes, Sebastián E. Illanes, Jaime Gutiérrez   +10 more
doaj   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Fungal Elicitation Enhances Vincristine and Vinblastine Yield in the Embryogenic Tissues of Catharanthus roseus

Plants, 2023
Fungal elicitation could improve the secondary metabolite contents of in vitro cultures. Herein, we report the effect of Fusarium oxysporum on vinblastine and vincristine alkaloid yields in Catharanthus roseus embryos. The study revealed increased yields
Dipti Tonk, Abdul Mujib, Mehpara Maqsood, Mir Khusrau, Ali Alsughayyir, Yaser Hassan Dewir   +5 more
doaj   +1 more source

Monitoring Muscle Stem Cell Cultures with Impedance Spectroscopy [PDF]

, 2018
The aim of this work is to present a new circuit for the real-time monitoring the processes of cellular growth and differentiation of skeletal myoblast cell cultures.
Huertas Sánchez, Gloria, Maldonado-Jacobi, Andrés, Olmo Fernández, Alberto, Pereira, Sheila, Portilla de Juan, Fernando de la, Pérez García, Pablo, Serrano, Juan A., Yuste, Yaiza, Yúfera García, Alberto   +8 more
core   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Tissue-Specific Natural Synthesis of Galanthaminein Zephyranthes Species and Its Accumulation in Different In Vitro-Grown Organs Following Methyl Jasmonate Treatment

Plants
Galanthamine is an immensely valuable alkaloid exhibiting anti-cancer and antiviral activity. The cultivation of plant tissues in in vitro conditions is a good source for the synthesis and enrichment of secondary metabolites of commercial interest.
Rukaya Syeed, A. Mujib, Yashika Bansal, Mohammad Mohsin, Afeefa Nafees, Moien Qadir Malik, Jyoti Mamgain, Bushra Ejaz, Yaser Hassan Dewir, Katalin Magyar-Tábori   +9 more
doaj   +1 more source

Minimal hepatic glucose-6-phosphatase-α activity required to sustain survival and prevent hepatocellular adenoma formation in murine glycogen storage disease type Ia

Molecular Genetics and Metabolism Reports, 2015
Glycogen storage disease type Ia (GSD-Ia), characterized by impaired glucose homeostasis and chronic risk of hepatocellular adenoma (HCA), is caused by a deficiency in glucose-6-phosphatase-α (G6Pase-α or G6PC) activity.
Young Mok Lee, Goo-Young Kim, Chi-Jiunn Pan, Brian C. Mansfield, Janice Y. Chou   +4 more
doaj   +1 more source