Results 81 to 90 of about 4,342,740 (357)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Meta-analysis reveals obesity associated gut microbial alteration patterns and reproducible contributors of functional shift

open access: yesGut Microbes
The majority of cohort-specific studies associating gut microbiota with obesity are often contradictory; thus, the replicability of the signature remains questionable.
Deep Chanda, Debojyoti De
doaj   +1 more source

Hematopoietic Cytokine Gene Duplication in Zebrafish Erythroid and Myeloid Lineages

open access: yesFrontiers in Cell and Developmental Biology, 2018
Hematopoiesis is a precisely orchestrated process regulated by the activity of hematopoietic cytokines and their respective receptors. Due to an extra round of whole genome duplication during vertebrate evolution in teleost fish, zebrafish have two ...
Jana Oltova   +3 more
doaj   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Relatedness and the evolution of mechanisms to divide labor in microorganisms

open access: yesEcology and Evolution, 2021
Division of labor occurs when cooperating individuals specialize to perform different tasks. In bacteria and other microorganisms, some species divide labor by random specialization, where an individual's role is determined by random fluctuations in ...
Ming Liu   +2 more
doaj   +1 more source

Hierarchical folding and reorganization of chromosomes are linked to transcriptional changes in cellular differentiation

open access: yesMolecular Systems Biology, 2015
Mammalian chromosomes fold into arrays of megabase‐sized topologically associating domains (TADs), which are arranged into compartments spanning multiple megabases of genomic DNA.
J. Fraser   +21 more
semanticscholar   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Differentiable cellular automata

open access: yes, 2017
We describe a class of cellular automata (CAs) that are end-to-end differentiable. DCAs interpolate the behavior of ordinary CAs through rules that act on distributions of states. The gradient of a DCA with respect to its parameters can be computed with an iterative propagation scheme that uses previously-computed gradients and values.
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Control of cellular differentiation [PDF]

open access: yesNature, 1977
The Differentiation of Cells. By N. Maclean. Pp. iii + 216. (Edward Arnold: London, 1977.) Hardback £12; paperback £5.95.
openaire   +1 more source

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