Results 61 to 70 of about 1,059,847 (263)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Interferon-γ: biological function and application for study of cellular immune response

Журнал инфектологии, 2016
Cellular immune response plays a central role in control of intracellular pathogens like viruses, some bacteria and parasites. Evaluation of presence, specificity and strength of cellular immune response can be done by investigation of reaction of immune
A. A. Lutckii, A. A. Zhirkov, D. Yu. Lobzin, M. Rao, L. A. Alekseeva, M. Maeurer, Yu. V. Lobzin   +6 more
doaj   +1 more source

Comparative Study of Cellular Immune Response in Cutaneous Blastomycosis [PDF]

Engineering and Technology Journal, 2012
Background: The immune response against Blastomyces dermatiditis is less clear than that of Histoplasma spp. or Coccidioides spp. This study was done to evaluate the cellular immune host response in patients with ulcerative and verrucous skin lesions ...
Haider Faisal, Hiba T. Hussain, Azhar A. F. Al-attrraqhchi   +2 more
doaj   +1 more source

Analysis of the Cellular Immune Responses to Vaccines

, 2016
Flow cytometry, enzyme-linked immunospot (ELISpot), and cellular cytotoxicity assays are powerful tools for studying the cellular immune response toward intracellular pathogens and vaccines in livestock species. Lymphocytes from immunized animals can be purified using Ficoll-Paque density gradient centrifugation and evaluated for their antigen ...
Svitek, Nicholas, Taracha, E.L.N., Saya, R., Awino, Elias, Nene, Vishvanath, Steinaa, Lucilla   +5 more
openaire   +5 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Immune responses result in misdiagnosis of Schistosoma japonicum by immunodiagnosis kits in egg-positive patients living in a low schistosomiasis transmission area of China

Parasites & Vectors, 2014
Background In recent field surveys, we failed to detect the presence of specific antibody against Schistosoma japonicum in some egg-positive patients by commonly used immunodiagnostic kits.
Shu-Ying Xie, Min Yuan, Min-Jun Ji, Fei Hu, Zhao-Jun Li, Yue-Min Liu, Xiao-Jun Zeng, Hong-Gen Chen, Hai-Wei Wu, Dan-Dan Lin   +9 more
doaj   +1 more source

SPECIFICITY OF CELLULAR IMMUNE RESPONSES [PDF]

The Journal of Experimental Medicine, 1968
In vitro antigen stimulation of DNA synthesis in lymph node cultures from immunized guinea pigs can be obtained with very low (10–4 µg/ml) antigen concentrations in the culture fluid. Immunization with low doses of DNP-GPA leads to a cell population capable of being stimulated, on the average, by low concentration of antigen whereas immunization with ...
William E. Paul, Gregory W. Siskind, Baruj Benacerraf   +2 more
openaire   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Validation of CCL20-driven CAR-γδ T secreting PD-1 blockade with enhanced trafficking into solid tumor

iScience
Summary: The primary challenges of CAR-T cells for solid tumor treatment involve the efficient delivery and infiltration of CAR-T cells into the tumor site, as well as overcoming the immunosuppressive tumor microenvironment.
Dengji Zhang, Yuan Tang, Wei Sun, Yunkun Guan, Yipeng Cheng, Yuqi Zhu, Xiaying Zhao, Xinyi Yang, Huanzhang Zhu   +8 more
doaj   +1 more source