Results 91 to 100 of about 2,055,112 (303)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Identification of Early Cellular Immune Factors Regulating Growth of Malaria Parasites in Humans [PDF]

, 2005
In many host-parasite systems, regulatory T cells (CD4+, CD25+, FOXP3+) have been shown to modulate cellular immunity and pathology. In this issue of Immunity, Walther et al.
F. Good, Michael, Good, Michael F.
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Experimental cerebral malaria develops independently of caspase recruitment domain-containing protein 9 signaling.

, 2011
The outcome of infection depends on multiple layers of immune regulation, with innate immunity playing a decisive role in shaping protection or pathogenic sequelae of acquired immunity.
Jan Burgold, Hafalla, J.C., Kai Matuschewski, Julius Clemence R. Hafalla, Gross, Olaf, Jürgen Ruland, Stefan H. E. Kaufmann, Kaufmann, Stefan H. E., Olaf Gross, Hafalla, Julius Clemence R., Gross, O., Matuschewski, K., Matuschewski, Kai, Ruland, Jürgen, Kaufmann, Stefan HE, Ruland, J., Burgold, Jan, Hafalla, Julius Clemence R, Dorhoi, Anca, Burgold, J., Anca Dorhoi, Dorhoi, A., Kaufmann, S.H., Hafalla, JC;Burgold, J;Dorhoi, A;Gross, O;Ruland, J;Kaufmann, SH;Matuschewski, K   +23 more
core   +1 more source

Cellular tumor necrosis factor, gamma interferon, and interleukin-6 responses as correlates of immunity and risk of clinical Plasmodium falciparum malaria in children from Papua New Guinea [PDF]

, 2009
The role of early to intermediate Plasmodium falciparum-induced cellular responses in the development of clinical immunity to malaria is not well understood, and such responses have been proposed to contribute to both immunity and risk of clinical ...
Mueller, Ivo, Schofield, Louis, Richards, Jack S., G. Beeson, James, C. D⿿Ombrain, Marthe, S. Richards, Jack, Bernard, Nicholas, Stanisic, Danielle I., Taraika, Jack, D'Ombrain, Marthe C., Tavul, Livingstone, J. Robinson, Leanne, Michon, Pascal, Robinson, Leanne J., Beeson, James G., I.Stanisic, Danielle   +15 more
core   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Combinatorial contextualization of peptidic epitopes for enhanced cellular immunity. [PDF]

, 2014
Invocation of cellular immunity by epitopic peptides remains largely dependent on empirically developed protocols, such as interfusion of aluminum salts or emulsification using terpenoids and surfactants.
Kazumi Hayashi (583143), Shigeo Koido (390312), Sadamu Homma (390313), Kiyotaka Shiba (29706), Hayashi Kazumi, Adachi Eru, Shiba Kiyotaka, Kazumi Hayashi, Koido Shigeo, Shigeo Koido, Kiyotaka Shiba, Masaki Ito (342933), Sadamu Homma, Homma Sadamu, Eru Adachi, Masaki Ito, Ito Masaki, Eru Adachi (649036), Minamisawa Tamiko, Tamiko Minamisawa, Tamiko Minamisawa (29705)   +20 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

HIF Transcription Factors, Inflammation, and Immunity [PDF]

, 2014
The hypoxic response in cells and tissues is mediated by the family of hypoxia-inducible factor (HIF) transcription factors; these play an integral role in the metabolic changes that drive cellular adaptation to low oxygen availability.
Palazon, A, Goldrath, AW, Palazon, Asis, Goldrath, Ananda W., Johnson, RS, Nizet, V, Nizet, Victor, Johnson, Randall S.   +7 more
core   +1 more source

Strength of Neisseria meningitidis binding to endothelial cells requires highly-ordered CD147/β2-adrenoceptor clusters assembled by alpha-actinin-4

Nature Communications, 2017
Neisseria meningitidis bacteria bind to host proteins CD147 and β2-adrenergic receptor on the surface of endothelial cells. Here, Maïssa et al. show that the two proteins interact with each other forming clusters that increase the binding strength of the
Nawal Maïssa, Valentina Covarelli, Sébastien Janel, Beatrice Durel, Nandi Simpson, Sandra C. Bernard, Liliana Pardo-Lopez, Haniaa Bouzinba-Ségard, Camille Faure, Mark G.H. Scott, Mathieu Coureuil, Philippe C. Morand, Frank Lafont, Xavier Nassif, Stefano Marullo, Sandrine Bourdoulous   +15 more
doaj   +1 more source