Results 71 to 80 of about 565,520 (309)

HIF Transcription Factors, Inflammation, and Immunity [PDF]

, 2014
The hypoxic response in cells and tissues is mediated by the family of hypoxia-inducible factor (HIF) transcription factors; these play an integral role in the metabolic changes that drive cellular adaptation to low oxygen availability.
Palazon, A, Goldrath, AW, Palazon, Asis, Goldrath, Ananda W., Johnson, RS, Nizet, V, Nizet, Victor, Johnson, Randall S.   +7 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Immune mechanisms of protection: can adjuvants rise to the challenge? [PDF]

, 2010
For many diseases vaccines are lacking or only partly effective. Research on protective immunity and adjuvants that generate vigorous immune responses may help generate effective vaccines against such ...
MacLeod Megan KL, Philippa Marrack, Amy S McKee, Marrack, P., Megan KL MacLeod, Marrack Philippa, Kappler, J.W., John W Kappler, MacLeod, M.K.L., Kappler John W, McKee, A.S., McKee Amy S   +11 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Combinatorial contextualization of peptidic epitopes for enhanced cellular immunity. [PDF]

, 2014
Invocation of cellular immunity by epitopic peptides remains largely dependent on empirically developed protocols, such as interfusion of aluminum salts or emulsification using terpenoids and surfactants.
Kazumi Hayashi (583143), Shigeo Koido (390312), Sadamu Homma (390313), Kiyotaka Shiba (29706), Hayashi Kazumi, Adachi Eru, Shiba Kiyotaka, Kazumi Hayashi, Koido Shigeo, Shigeo Koido, Kiyotaka Shiba, Masaki Ito (342933), Sadamu Homma, Homma Sadamu, Eru Adachi, Masaki Ito, Ito Masaki, Eru Adachi (649036), Minamisawa Tamiko, Tamiko Minamisawa, Tamiko Minamisawa (29705)   +20 more
core   +1 more source

A disease‐associated missense mutation in CYP4F3 affects the metabolism of leukotriene B4 via disruption of electron transfer

Journal of Cachexia, Sarcopenia and Muscle, 2022
Background Cytochrome P450 4F3 (CYP4F3) is an ω‐hydroxylase that oxidizes leukotriene B4 (LTB4), prostaglandins, and fatty acid epoxides. LTB4 is synthesized by leukocytes and acts as a chemoattractant for neutrophils, making it an essential component of
Elien Smeets, Shengyun Huang, Xiao Yin Lee, Erika Van Nieuwenhove, Christine Helsen, Florian Handle, Lisa Moris, Sarah El Kharraz, Roy Eerlings, Wout Devlies, Mathijs Willemsen, Leoni Bücken, Teresa Prezzemolo, Stephanie Humblet‐Baron, Arnout Voet, Anne Rochtus, Ann Van Schepdael, Francis deZegher, Frank Claessens   +18 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Measuring immunity : basic biology and clinical assessment / [PDF]

, 2005
Most of the diseases of modern mankind involve either acute or chronic inflammation. Measuring Immunity integrates the current information available on biomarkers and surrogate assays into a single handbook.
Lotze, Michael T., Thomson, Angus W.
core  

REACTOGENITY OF TICK-BORNE ENCEPHALITIS VACCINE ENCEPUR ADULT AND IMMUNE RESPONSE

Медицинская иммунология, 2014
. The comprehensive clinical-immunological characteristic of a tick-borne encephalitis vaccine En-cepur Adult (Germany), which was studied on a group of residents of Far East of Russia was discussed.
G. N. Leonova, N. V. Krylova, E. V. Pavlenko, O. S. Maystrovskaya   +3 more
doaj   +1 more source

Immune correlates of protection following Rift Valley fever virus vaccination

npj Vaccines, 2022
Rift Valley fever virus (RVFV) is a hemorrhagic fever virus with the potential for significant economic and public health impact. Vaccination with an attenuated strain, DelNSsRVFV, provides protection from an otherwise lethal RVFV challenge, but ...
Joshua D. Doyle, Dominique J. Barbeau, Haley N. Cartwright, Anita K. McElroy   +3 more
doaj   +1 more source