Results 51 to 60 of about 2,153,248 (300)

Neurocognitive, School‐Based, and Quality of Life Outcomes for Youth With Sickle Cell Disease and Thalassemia: A Scoping Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT The medical burdens of sickle cell disease (SCD) and transfusion‐dependent β‐thalassemia (TDT) are chronic and cumulative, even in children. Yet the effects expand beyond medications and healthcare visits due to their impacts on school attendance, academic performance, and peer engagement.
Mary Ann Etling, Hakim Tokhi, Alexander A. Boucher   +2 more
wiley   +1 more source

Determination of HMGB1 in hepatitis B virus-related acute-on-chronic liver failure patients with acute kidney injury: Early prediction and prognostic implications

Frontiers in Pharmacology, 2023
Background: Acute kidney injury (AKI) is a frequent complication in patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) and is associated with high rates of mortality. We aimed to estimate serum high mobility group protein 1
Yu Liu, Yu Liu, Wei Yuan, Miao Fang, Hongying Guo, Xin Zhang, Xue Mei, Yuyi Zhang, Longshan Ji, Yating Gao, Jiefei Wang, Zhiping Qian, Man Li, Yueqiu Gao, Yueqiu Gao   +14 more
doaj   +1 more source

Integrated antibody and cellular immunity monitoring are required for assessment of the long term protection that will be essential for effective next generation vaccine development

Frontiers in Immunology, 2023
The COVID pandemic exposed the critical role T cells play in initial immunity, the establishment and maintenance of long term protection, and of durable responsiveness against novel viral variants.
Eustache Paramithiotis, Christophe Varaklis, Stephane Pillet, Shahin Shafiani, Mary Pat Lancelotta, Steve Steinhubl, Steve Steinhubl, Scott Sugden, Matt Clutter, Damien Montamat-Sicotte, Todd Chermak, Stephanie Y. Crawford, Bruce L. Lambert, John Mattison, Robert L. Murphy   +14 more
doaj   +1 more source

Effect of DFPP on Ferroptosis in Peripheral Blood CD14+ Monocytes of Hyperlipidemic Patients Involving the ACSL4/LPCAT3/ALOX5 Pathway

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease (ASCVD). Although statins are the cornerstone of lipid‐lowering therapy, their use may be limited in some patients by adverse effects. This study evaluated the possible impact of non‐drug treatment using double‐filtration plasmapheresis (DFPP) on CD14+
Yun Cheng, Lan Li, Qingmei Yang, Meipeng Wu   +3 more
wiley   +1 more source

PTX3 is expressed in terminal lymphatics and shapes their organization and function

Frontiers in Immunology
IntroductionThe lymphatic system is a multifaceted regulator of tissue homeostasis and an integral part of immune responses. Previous studies had shown that subsets of lymphatic endothelial cells (LEC) express PTX3, an essential component of humoral ...
Andrea Doni, Marina Sironi, Annalisa Del Prete, Annalisa Del Prete, Fabio Pasqualini, Sonia Valentino, Ivan Cuccovillo, Raffaella Parente, Michela Calvi, Antonella Tosoni, Gianluca Vago, Manuela Nebuloni, Cecilia Garlanda, Cecilia Garlanda, Annunciata Vecchi, Barbara Bottazzi, Alberto Mantovani, Alberto Mantovani, Alberto Mantovani   +18 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Investigations of cellular immunity in juvenile idiopathic arthritis

Central European Journal of Immunology, 2019
The following was emphasised in an informative, educational issued on the American College of Rheumatology website in April 2017: “About one child in every 1000 develops some type of chronic arthritis.
Lucia Maria Sur, Genel Sur, Gabriel Samasca, Iulia Lupan   +3 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

CONDITION OF CELLULAR IMMUNITY AFTER COMPLICATIONS OF DENTAL IMPLANTATION

, 2018
CONDITION OF CELLULAR IMMUNITY AFTER COMPLICATIONS OF DENTAL ...
U.D. Matolych
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source