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GLP-1 receptor agonists can reverse immunosuppression-induced beta-cell dysfunction [PDF]

open access: yesCellR4, 2020
It is well known that some of the agents commonly used during immunosuppressive (IS) therapy after solid organ transplantation can contribute to beta cell dysfunction and result in diabetes mellitus in the transplant recipient.
S. Bertera   +5 more
doaj   +1 more source

Cellular Neural Networks [PDF]

open access: yes, 2001
As stated in the chapter of Cellular Genetic Algorithm, an individual cell plays the roles of both “chromosome” and “gene”. Though the roles are different, they all reflect the function of “information transmission by the rules” and the intelligent form of the cells.
Ákos Zarándy   +2 more
  +7 more sources

Neutrophil-Associated Inflammatory Changes in the Pre-Diabetic Pancreas of Early-Age NOD Mice

open access: yesFrontiers in Endocrinology, 2021
A growing body of evidence indicates that neutrophils are the first major leukocyte population accumulating inside the pancreas even before the onset of a lymphocytic-driven impairment of functional beta cells in type 1 diabetes mellitus (T1D). In humans,
Yesica Garciafigueroa   +6 more
doaj   +1 more source

Human islet isolation: status and future considerations* [PDF]

open access: yesCellR4, 2019
Autologous human islet transplantation to mitigate or prevent surgically induced diabetes after total pancreatectomy for the relief of chronic pancreatitisinduced pain was pioneered in the late 1970s.
R. Bottino   +4 more
doaj   +1 more source

Improvement in insulin sensitivity and prevention of high fat diet-induced liver pathology using a CXCR2 antagonist

open access: yesCardiovascular Diabetology, 2022
Background Liver pathology (LP) characteristic of non-alcoholic fatty acid disease (NAFLD)/non-alcoholic steatohepatitis (NASH) is a prevalent co-morbidity of type 2 diabetes (T2D).
Brett E. Phillips   +8 more
doaj   +1 more source

Arrest in the Progression of Type 1 Diabetes at the Mid-Stage of Insulitic Autoimmunity Using an Autoantigen-Decorated All-trans Retinoic Acid and Transforming Growth Factor Beta-1 Single Microparticle Formulation

open access: yesFrontiers in Immunology, 2021
Type 1 diabetes (T1D) is a disorder of impaired glucoregulation due to lymphocyte-driven pancreatic autoimmunity. Mobilizing dendritic cells (DC) in vivo to acquire tolerogenic activity is an attractive therapeutic approach as it results in multiple and ...
Brett E. Phillips   +10 more
doaj   +1 more source

Management of congenital dysfibrinogenemia in pregnancy: A challenging patient case

open access: yesResearch and Practice in Thrombosis and Haemostasis, 2021
Afibrinogenemia and congenital dysfibrinogenemia (CD) are rare conditions with limited information available for appropriate management. Previous case reports have demonstrated the safe and efficacious use of fibrinogen replacement therapy (FRT) as a ...
Megan Langer   +5 more
doaj   +1 more source

Human Neural Stem Cells for Cell-Based Medicinal Products

open access: yesCells, 2021
Neural stem cells represent an attractive tool for the development of regenerative therapies and are being tested in clinical trials for several neurological disorders.
Beatriz Fernandez-Muñoz   +3 more
doaj   +1 more source

Ddb1 Is Essential for the Expansion of CD4+ Helper T Cells by Regulating Cell Cycle Progression and Cell Death

open access: yesFrontiers in Immunology, 2021
Follicular helper T (TFH) cells are specialized CD4+ helper T cells that provide help to B cells in humoral immunity. However, the molecular mechanism underlying generation of TFH cells is incompletely understood.
Lingtao Yang   +12 more
doaj   +1 more source

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