Results 21 to 30 of about 1,492,586 (335)

An intracellular membrane protein GEP1 regulates xanthurenic acid induced gametogenesis of malaria parasites

open access: yesNature Communications, 2020
Mosquito-derived xanthurenic acid (XA) is a trigger for gametogenesis of Plasmodium parasites. Here the authors show that the putative amino acid transporter GEP1 is required for XA-stimulated gametogenesis in Plasmodium yoelii and that it interacts with
Yuanyuan Jiang   +14 more
doaj   +1 more source

A Case of Vancomycin-Induced Severe Immune Thrombocytopenia

open access: yesHematology Reports, 2023
A male in his 60s presented with left lower extremity fractures following a vehicle accident. Hemoglobin, initially, was 12.4 mmol/L, and platelet count was 235 k/mcl.
Shivani Shah   +3 more
doaj   +1 more source

Principles of microRNA regulation of a human cellular signaling network [PDF]

open access: yes, 2006
MicroRNAs (miRNAs) are endogenous 22-nucleotide RNAs, which suppress gene expression by selectively binding to the 3-noncoding region of specific message RNAs through base-pairing.
Edwin Wang   +4 more
core   +3 more sources

Human Hemangioblast-Derived Mesenchymal Stem Cells Promote Islet Engraftment in a Minimal Islet Mass Transplantation Model in Mice

open access: yesFrontiers in Medicine, 2021
Islet transplantation can restore glycemic control in patients with type 1 diabetes. Using this procedure, the early stages of engraftment are often crucial to long-term islet function, and outcomes are not always successful.
Suzanne Bertera   +14 more
doaj   +1 more source

The Future of Islet Transplantation Is Now

open access: yesFrontiers in Medicine, 2018
Milestones in the history of diabetes therapy include the discovery of insulin and successful methods of beta cell replacement including whole pancreas and islet cell transplantation options.
Rita Bottino   +8 more
doaj   +1 more source

Simplicial Homology for Future Cellular Networks [PDF]

open access: yes, 2014
Simplicial homology is a tool that provides a mathematical way to compute the connectivity and the coverage of a cellular network without any node location information. In this article, we use simplicial homology in order to not only compute the topology
Decreusefond, Laurent   +2 more
core   +5 more sources

A new ALK inhibitor overcomes resistance to first‐ and second‐generation inhibitors in NSCLC

open access: yesEMBO Molecular Medicine, 2021
More than 60% of nonsmall cell lung cancer (NSCLC) patients show a positive response to the first ALK inhibitor, crizotinib, which has been used as the standard treatment for newly diagnosed patients with ALK rearrangement.
Yue Lu   +28 more
doaj   +1 more source

RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome

open access: yesNature Communications, 2017
Mitochondrial reactive oxygen species (ROS) promote necroptosis and the receptor interacting protein 1 (RIP1) is a key player in this form of cell death.
Yingying Zhang   +10 more
doaj   +1 more source

Structural Basis for PPARs Activation by The Dual PPARα/γ Agonist Sanguinarine: A Unique Mode of Ligand Recognition

open access: yesMolecules, 2021
Peroxisome proliferator-activated receptors (PPARs) play crucial roles in glucose and lipid metabolism and inflammation. Sanguinarine is a natural product that is isolated from Sanguinaria Canadensis, a potential therapeutic agent for intervention in ...
Siyu Tian   +5 more
doaj   +1 more source

Optimal Non-uniform Deployments in Ultra-Dense Finite-Area Cellular Networks [PDF]

open access: yes, 2017
Network densification and heterogenisation through the deployment of small cellular access points (picocells and femtocells) are seen as key mechanisms in handling the exponential increase in cellular data traffic.
Dettmann, Carl P.   +2 more
core   +2 more sources

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