Results 81 to 90 of about 928,680 (341)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Drug repurposing for the treatment of glioblastoma multiforme

Journal of Experimental & Clinical Cancer Research, 2017
Background Glioblastoma Multiforme is the deadliest type of brain tumor and is characterized by very poor prognosis with a limited overall survival.
Claudia Abbruzzese, Silvia Matteoni, Michele Signore, Luca Cardone, Kavindra Nath, Jerry D. Glickson, Marco G. Paggi   +6 more
doaj   +1 more source

A novel load-balancing scheme for cellular-WLAN heterogeneous systems with cell-breathing technique [PDF]

, 2018
This paper proposes a novel load-balancing scheme for an operator-deployed cellular-wireless local area network (WLAN) heterogeneous network (HetNet), where the user association is controlled by employing a cell-breathing technique for the WLAN network ...
Dianati, Mehrdad, Imran, Muhammad Ali, Navaratnarajah, Shobanraj   +2 more
core   +1 more source

Analysis of cellular and synaptic mechanisms behind spontaneous cortical activity in vitro : Insights from optimization of spiking neuronal network models [PDF]

, 2021
Jugoslava Aćimović, Tuomo Mäki‐Marttunen, Heidi Teppola, Marja‐Leena Linne   +3 more
openalex   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Massive Non-Orthogonal Multiple Access for Cellular IoT: Potentials and Limitations

, 2016
The Internet of Things (IoT) promises ubiquitous connectivity of everything everywhere, which represents the biggest technology trend in the years to come.
Dohler, Mischa, Johnson, Sarah, Shirvanimoghaddam, Mahyar   +2 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Inactivation of HIPK2 attenuates KRASG12D activity and prevents pancreatic tumorigenesis

Journal of Experimental & Clinical Cancer Research
Background Pancreatic ductal adenocarcinoma (PDAC) features KRAS mutations in approximately 90% of human cases and excessive stromal response, termed desmoplastic reaction.
Silvia Sozzi, Isabella Manni, Cristiana Ercolani, Maria Grazia Diodoro, Armando Bartolazzi, Francesco Spallotta, Giulia Piaggio, Laura Monteonofrio, Silvia Soddu, Cinzia Rinaldo, Davide Valente   +10 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Phlorotannins from Ecklonia cava Attenuates Palmitate-Induced Endoplasmic Reticulum Stress and Leptin Resistance in Hypothalamic Neurons

Marine Drugs, 2019
Leptin resistance in the hypothalamus has an essential role in obesity. Saturated fatty acids such as palmitate bind to Toll-like receptor 4 (TLR4) and lead to endoplasmic reticulum (ER) stress and leptin resistance.
Seyeon Oh, Myeongjoo Son, Junwon Choi, Chang Hu Choi, Kook Yang Park, Kuk Hui Son, Kyunghee Byun   +6 more
doaj   +1 more source