Results 101 to 110 of about 432,489 (267)

PARP Inhibition Shifts Murine Myeloid Cells Toward a More Tolerogenic Profile In Vivo

Biomolecules
The human Poly ADP-ribose Polymerase (PARP) family comprises 17 enzymes responsible for the transfer of ADP-ribose to proteins, forming poly- or mono-ADP-ribosylation.
Jose R. Pittaluga-Villarreal, Casey M. Daniels, Tara Capece, Pauline R. Kaplan, Martin Meier-Schellersheim, Aleksandra Nita-Lazar   +5 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Beyond natural biology: rewiring cellular networks to study innate immunity. [PDF]

Curr Opin Immunol, 2023
Landau LM, Kagan JC.
europepmc   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Kinase Mobility Shift Assay (KiMSA) for Assessing Protein Kinase A Activity

Bio-Protocol
The cAMP-dependent protein kinase (PKA) is one of the most extensively distributed kinases among intracellular signal cascades, with a pivotal role in the regulation of various processes, including the capacitation of sperm cells. Traditional assessments
Analia Novero, Tomás Steeman, Catalina Curcio, Lara Buccolini, Andres Binolfi, Diego Krapf, Mariano Buffone, Dario Krapf, Cintia Stival   +8 more
doaj   +1 more source

Interference mitigation in intentional jammers aided non-uniform heterogeneous cellular networks. [PDF]

PLoS One, 2023
Ghonaim SM, Khan S, Althobiani F, Alghaffari S, Khan S, Irfan M, Haroon MS, Muhammad F.   +7 more
europepmc   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Transform-Based Multiresolution Decomposition for Unsupervised Learning and Data Clustering of Cellular Network Behavior

IEEE Access
The growing complexity of cellular networks makes it harder for network operators to control and manage the system. To ease the management and automatically detect network problems, unsupervised techniques have been put to use. This work proposes a novel
Juan Cantizani-Estepa, Sergio Fortes, Javier Villegas, Javier Rasines, Raul Martin Cuerdo, Raquel Barco   +5 more
doaj   +1 more source