Results 1 to 10 of about 980 (147)
Intratympanic Administration of Dieckol Prevents Ototoxic Hearing Loss
Marine Drugs, 2022 Objective. Systemic administration of dieckol reportedly ameliorates acute hearing loss. In this study, dieckol was delivered to the inner ear by the intratympanic route.
Myung-Whan Suh, Seung-Ha Oh, Hui Li
exaly +4 more sources
Marine Drugs, 2015 We investigated the effect of Ecklonia cava (E. cava)-derived dieckol on movement behavior and the expression of migration-related genes in MCF-7 human breast cancer cell.
Yon-Suk Kim, Eun-Kyung Kim, Pyo-Jam Park
exaly +4 more sources
Dieckol Ameliorates Aβ Production via PI3K/Akt/GSK-3β Regulated APP Processing in SweAPP N2a Cell
Marine Drugs, 2021 The proteolytic processing of amyloid precursor protein (APP) by β-secretase (BACE1) and γ-secretase releases amyloid-β peptide (Aβ), which deposits in amyloid plaques and contributes to the initial causative events of Alzheimer’s disease (AD).
Jeong-Hyun Yoon +7 more
doaj +2 more sources
Marine Drugs, 2022 Repetitive exposure to ultraviolet B (UVB) is one of the main causes of skin photoaging. We previously reported that dieckol isolated from Eisenia bicyclis extract has potential anti-photoaging effects in UVB-irradiated Hs68 cells.
Jae-Min Kim +10 more
doaj +2 more sources
Marine Drugs, 2022 Dieckol, a phlorotannin from Ecklonia cava, has shown potential for use as an anticancer agent that selectively kills cancer cells. However, it is necessary to amplify its potency without damaging its inherent safety in order to develop it as a ...
Hyeon-Cheol Shin +6 more
doaj +2 more sources
Biomedicines, 2021 Nitric oxide (NO), an endothelial-derived relaxing factor synthesized by endothelial nitric oxide synthase (eNOS) in endothelial cells, enhances vasodilation by modulating vascular tone.
Yu-An Lu +4 more
doaj +2 more sources
Frontiers in Marine Science, 2023 Ecklonia cava (EC), an edible brown macroalga abundant in intertidal areas of East Asia (Korea, Japan, and China), contains high-value bioactive compounds such as dieckol, which has antifungal, anti-inflammatory, antitumor, and antihyperlipidemic ...
Hyeonmi Shin +5 more
doaj +1 more source
Frontiers in Endocrinology, 2022 BackgroundGlucocorticoids (GCs) induce osteoporosis, which results in fractures in the bond, causing significant morbidity. In the conducted study, we examined the antiosteoporosis effect of dieckol against GC-induced osteoporosis in rats.MethodsSprague ...
Hao Wang, Leigang Yang, Junwei Chao
doaj +1 more source
Frontiers in Pharmacology, 2020 We had previously demonstrated that phlorotannins, which are marine polyphenols, enhance sleep in mice via the GABAA-benzodiazepine (BZD) receptor. Among the constituents of phlorotannin, dieckol is a major marine polyphenol from the brown alga Ecklonia ...
Minseok Yoon +8 more
doaj +1 more source
Pharmacological Research, 2022 Background and purpose: Dieckol is a phlorotannin that can be found in seaweeds, particularly in Eisenia bicyclis (brown algae) and is known to have anti-oxidant, anti-inflammatory, and anti-microbial properties. It also possesses anti-thrombotic and pro-
Muhammad Irfan +3 more
doaj +1 more source