Marine Drugs, 2019 Modulation of multiple protein targets with a single compound is essential for the effective treatment of central nervous system disorders. In our previous G protein-coupled receptor (GPCR) cell-based study, a selective human monoamine oxidase (hMAO)-A ...
Su Hui Seong +6 more
doaj +2 more sources
Phlorotannins from Ecklonia cava Regulate Dual Signaling Pathways, IL-17RA/Act1 and ERK1/2, to Suppress Ovarian Cancer Progression and Tumor-Associated Macrophage Activation [PDF]
Marine DrugsBackground: Marine-derived secondary metabolites such as phlorotannins from the edible brown alga Ecklonia cava exhibit diverse bioactivities. However, their mechanisms in inflammation-associated cancer remain insufficiently understood.
Eun-Hye Kim +3 more
doaj +2 more sources
A Pharmacokinetic and Bioavailability Study of Ecklonia cava Phlorotannins Following Intravenous and Oral Administration in Sprague–Dawley Rats [PDF]
Marine DrugsThis study examines the pharmacokinetics and bioavailability of phlorotannins from Ecklonia cava in rats following intravenous and oral administration.
Hyeon-Cheol Shin +8 more
doaj +2 more sources
Algal and Fungal Antioxidants Alleviate Oxidative Stress-Induced Reproductive Defects. [PDF]
Food Sci NutrIn the in vivo models, fungi and/or algae‐derived metabolites (polysaccharides, carotenoids, ergothioneine, phycobiliproteins, phlorotannins, and cordycepin) correct the impaired reproductive functions in males and/or females by increasing antioxidant enzyme activities, decreasing oxidative stress, inflammation, and apoptosis, alleviating ovarian and ...
Arslan NP +9 more
europepmc +2 more sources
Marine Drugs, 2022 A global health concern has emerged as a response to the recent SARS-CoV-2 pandemic. The identification and inhibition of drug targets of SARS-CoV-2 is a decisive obligation of scientists.
D. P. Nagahawatta +8 more
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Unveiling synergistic antioxidant combinations for α-tocopherol in emulsions: A spectrophotometric-mathematical approach [PDF]
Current Research in Food ScienceThis study presents a novel method based on a spectrophotometric assay coupled with mathematical modeling (Weibull interactions modeling CAT) to evaluate synergistic interactions of antioxidants in an oil-in-water model emulsion. The approach addresses a
Camille Robichon +7 more
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Ecklonia cava Ameliorates Cognitive Impairment on Amyloid β-Induced Neurotoxicity by Modulating Oxidative Stress and Synaptic Function in Institute of Cancer Research (ICR) Mice [PDF]
AntioxidantsThis study investigated the neuroprotective effect of 70% ethanol extract of Ecklonia cava (EE) in amyloid beta (Aβ)-induced cognitive deficit mice.
Hyo Lim Lee +3 more
doaj +2 more sources
Enhancing NADPH to restore redox homeostasis and lysosomal function in G6PD-deficient microglia [PDF]
HeliyonMicroglia, the immune cells of the central nervous system (CNS), play key roles in neurogenesis, myelination, synaptic transmission, immune surveillance, and neuroinflammation.
Abir Mondal +5 more
doaj +2 more sources
Effects of antioxidants on skin hydration, inflammatory cytokines, and keratinocyte differentiation markers in a PM-exposed skin barrier–disrupted mouse model [PDF]
International Journal of Immunopathology and PharmacologyGiven that particulate matter (PM) has an established role in inducing oxidative stress, inflammation, and skin aging, it is plausible that PM could exacerbate inflammatory skin conditions such as xerosis.
Jin Ho Kim, Mi Hee Kwack, Weon Ju Lee
doaj +2 more sources
Asian Pacific Journal of Tropical Biomedicine, 2022 Objective: To demonstrate the effect of dieckol from Eisenia bicyclis on osteoclastogenesis using RAW 264.7 cells. Methods: Murine macrophage RAW 264.7 cells were subjected to dieckol treatment, followed by treatment with receptor activator of nuclear ...
Su-Hyeon Cho +10 more
doaj +1 more source