Results 21 to 30 of about 980 (147)

Dieckol, Derived from the Edible Brown Algae Ecklonia cava, Attenuates Methylglyoxal-Associated Diabetic Nephropathy by Suppressing AGE–RAGE Interaction

Antioxidants, 2023
The formation of advanced glycation end products (AGE) is linked to the pathogenesis of diabetic nephropathy. The aim of this work was to assess the therapeutic potential and underlying mechanism of action of dieckol (DK), isolated from Ecklonia cava, on
Chi-Heung Cho, Guijae Yoo, Mingyeong Kim, Ulfah Dwi Kurniawati, In-Wook Choi, Sang-Hoon Lee   +5 more
doaj   +2 more sources

Dieckol and Its Derivatives as Potential Inhibitors of SARS-CoV-2 Spike Protein (UK Strain: VUI 202012/01): A Computational Study

Marine Drugs, 2021
The high risk of morbidity and mortality associated with SARS-CoV-2 has accelerated the development of many potential vaccines. However, these vaccines are designed against SARS-CoV-2 isolated in Wuhan, China, and thereby may not be effective against ...
Mohammad Aatif, Ghazala Muteeb, Abdulrahman Alsultan, Adil Alshoaibi, Bachir Yahia Khelif   +4 more
doaj   +2 more sources

Attenuating Effects of Dieckol on High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease by Decreasing the NLRP3 Inflammasome and Pyroptosis

Marine Drugs, 2021
Nonalcoholic fatty liver disease (NAFLD), which promotes serious health problems, is related to the increase in the nucleotide-binding oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome and pyroptosis by a high ...
Seyeon Oh, Myeongjoo Son, Kyung-A Byun, Ji Tae Jang, Chang Hu Choi, Kuk Hui Son, Kyunghee Byun   +6 more
doaj   +2 more sources

Dieckol Reduces Muscle Atrophy by Modulating Angiotensin Type II Type 1 Receptor and NADPH Oxidase in Spontaneously Hypertensive Rats

Antioxidants, 2021
The renin–angiotensin system is involved in the development of hypertension and sarcopenia. Increased levels of angiotensin II (Ang II) lead to upregulation of Ang II type 1 receptor (AT1R), which results in increasing reactive oxygen species (ROS) by ...
Seyeon Oh, Jin Young Yang, Chul Hyun Park, Kuk Hui Son, Kyunghee Byun   +4 more
doaj   +2 more sources

Dieckol Decreases Caloric Intake and Attenuates Nonalcoholic Fatty Liver Disease and Hepatic Lymphatic Vessel Dysfunction in High-Fat-Diet-Fed Mice

Marine Drugs, 2021
Increased inflammation is the main pathophysiology of nonalcoholic fatty liver disease (NAFLD). Inflammation affects lymphatic vessel function that contributes to the removal of immune cells or macromolecules.
Kyung-A Byun, Seyeon Oh, Myeongjoo Son, Chul-Hyun Park, Kuk Hui Son, Kyunghee Byun   +5 more
doaj   +2 more sources

Method development and validation for dieckol in the standardization of phlorotannin preparations [PDF]

Fisheries and Aquatic Sciences, 2016
Phlorotannins are reported to have diverse biological properties. However, no analytical methods for the standardization of phlorotannin preparations have been reported.
Jiyoung Kim, Minyoung Um, Hyejin Yang, Inho Kim, Changho Lee, Yuntai Kim, Minseok Yoon, Youngkyoung Kim, Jimi Kim, Suengmok Cho   +9 more
doaj   +2 more sources

Anti-Melanogenesis and Photoprotective Effects of Ecklonia maxima Extract Containing Dieckol and Eckmaxol

Marine Drugs, 2022
Seaweeds are potential ingredients in the cosmeceutical industry. Our previous study demonstrates that the phlorotannin-enriched extract of Ecklonia maxima (EME-EA) containing dieckol and eckmaxol possesses strong anti-inflammatory activity and suggests ...
Lei Wang, Jun-Geon Je, Hyun-Soo Kim, Kaiqiang Wang, Xiaoting Fu, Jiachao Xu, Xin Gao, You-Jin Jeon   +7 more
doaj   +2 more sources

Isolation and Characterization of Efficient Active Compounds Using High-Performance Centrifugal Partition Chromatography (CPC) from Anti-Inflammatory Activity Fraction of Ecklonia maxima in South Africa

Marine Drugs, 2022
Ecklonia maxima is a brown seaweed, which is abundantly distributed in South Africa. This study investigated an efficient approach using high-performance centrifugal partition chromatography (HPCPC), which has been successfully developed for the ...
Hyun-Soo Kim, Jun-Geon Je, Hyesuck An, Kyunghwa Baek, Jeong Min Lee, Mi-Jin Yim, Seok-Chun Ko, Ji-Yul Kim, Gun-Woo Oh, Min-Cheol Kang, Young Min Ham, You-Jin Jeon, Dae-Sung Lee   +12 more
doaj   +2 more sources

Anti-Neuroinflammatory Property of Phlorotannins from Ecklonia cava on Aβ25-35-Induced Damage in PC12 Cells

Marine Drugs, 2018
Alzheimer disease (AD) is a neurodegenerative disorder characterized by excessive accumulation of amyloid-beta peptide (Aβ) and progressive loss of neurons.
Seungeun Lee, Kumju Youn, Dong Hyun Kim, Mok-Ryeon Ahn, Eunju Yoon, Oh-Yoen Kim, Mira Jun   +6 more
doaj   +2 more sources

Attenuating Effects of Dieckol on Endothelial Cell Dysfunction via Modulation of Th17/Treg Balance in the Intestine and Aorta of Spontaneously Hypertensive Rats

Antioxidants, 2021
Disruptions of the Treg/Th17 cell balance and gut barrier function are associated with endothelial dysfunction. Dieckol (DK) obtained from Ecklonia cava and E. cava extract (ECE) decreases blood pressure by reducing inflammation; however, it has not been
Seyeon Oh, Minjung Shim, Myeongjoo Son, Ji Tae Jang, Kuk Hui Son, Kyunghee Byun   +5 more
doaj   +2 more sources