Results 141 to 150 of about 1,766,854 (293)

Central role of regular firing neurons of centrolateral amygdala in affective behaviors

iScience
Summary: Anxiety and depression are highly prevalent psychiatric disorders with poorly understood neural mechanisms. The amygdala, particularly its hyperactivity, is strongly implicated in anxiety.
Alvaro García, M. Isabel Aller, Ana V. Paternain, Juan Lerma   +3 more
doaj   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Optical defocus affects differently ON and OFF visual pathways

iScience
Summary: The human eye has a crystalline lens that focuses retinal images at different viewing distances. Optical defocus reduces the spatial resolution and contrast of these retinal images and spectacle lenses minify or magnify their size. Because light
Carmen Pons, Reece Mazade, Jianzhong Jin, Mitchell W. Dul, Jose-Manuel Alonso   +4 more
doaj   +1 more source

Role of arachidonic acid metabolites in habituation in the leech Hirudo medicinalis

, 2006
Program N° 535.1. 2006 Neuroscience Meeting Planner.
Brunelli M., Lombardo P., Cataldo E., Scuri R., Ristori C., TRAINA, Giovanna   +5 more
core  

Neuroscience Literacy and Academic Outcomes: Insights from a University Student Population

Background/Objectives: There is growing interest in neuroscience-informed education, as well as neuroscience-derived strategies that maximise learning.
Elaf M. Aljared, Abeer F. Almarzouki, Arzan I. Alqahtani, Dhuha K. Badaood, Reema S. Alghamdi, Jumana K. Baessa, Raneem W. Malibari, Rwdyn R. Nujoom   +7 more
core   +1 more source

Validation of a Cellular Imaging‐Based Method as a Potential Biomarker for SPG4 Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini, Valerio Licursi, Gianmarco Dalla Zanna, Flavio Dal Canto, Melissa Barghigiani, Nunzio Setola, Salvatore Rossi, Antonio Funcis, Filippo M. Santorelli, Gabriella Silvestri, Carlo Casali, Francesca Sardina, Cinzia Rinaldo   +12 more
wiley   +1 more source

Sustained generation of neurons destined for neocortex with oxidative metabolic upregulation upon filamin abrogation

iScience
Summary: Neurons in the neocortex are generated during embryonic development. While the adult ventricular-subventricular zone (V-SVZ) contains cells with neural stem/progenitors’ characteristics, it remains unclear whether it has the capacity of ...
Caroline A. Kopsidas, Clara C. Lowe, Dennis P. McDaniel, Xiaoming Zhou, Yuanyi Feng   +4 more
doaj   +1 more source

The neuroprotective signaling mechanisms of telomerase via the induction by brain-derived neurotrophic factor in rat spinal cord motor neurons

, 2010
The 40th Annual Meting of the Society for Neuroscience (Neuroscience 2010), San Diego, CA., 13-17 November ...
Niu, C, Yip, HKF
core  

Disease Course After Anti‐CD20 Discontinuation in Secondary Progressive Multiple Sclerosis—A Multicenter Long‐Term Longitudinal Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To describe long‐term outcomes after anti‐CD20 discontinuation in selected patients with secondary progressive multiple sclerosis (SPMS) who remained without subsequent disease‐modifying therapy (DMT). Methods We retrospectively analyzed data from four centers in Austria and Switzerland.
Ferdinand Otto, Dariia Kliushnikova, Richard Friedrich Radlberger, Sinan Yasaroglu, Tobias Moser, Andrea Harrer, Kitty Kratzer, Wolfgang Hitzl, Christiane Gradl, Martin Schmidauer, Patrick Roth, Harald Hegen, Peter Wipfler   +12 more
wiley   +1 more source

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source