Results 81 to 90 of about 244,397 (293)

LPLAT11/MBOAT7-driven phosphatidylinositol remodeling ensures radial glial cell integrity in developing neocortex

iScience
Summary: Phosphatidylinositol (PI) is highly enriched in arachidonic acid, an essential polyunsaturated fatty acid for brain development. This enrichment is mediated by the phospholipid remodeling enzyme lysophospholipid acyltransferase 11 (LPLAT11 ...
Yuki Ishino, Yusuke Kishi, Taiga Iwama, Naohiro Kuwayama, Hiroyuki Arai, Yukiko Gotoh, Junken Aoki, Nozomu Kono   +7 more
doaj   +1 more source

Advancing Neuroscience and Therapy: Insights into Genetic and Non-Genetic Neuromodulation Approaches

Neuromodulation stands as a cutting-edge approach in the fields of neuroscience and therapeutic intervention typically involving the regulation of neural activity through physical and chemical stimuli. The purpose of this review is to provide an overview
Ying Li, Xiangjun Hu, Lifeng Wang, Weijia Zhi   +3 more
core   +1 more source

Non-Hebbian Long-Term Potentiation of Inhibitory Synapses in the Thalamus [PDF]

, 2013
The thalamus integrates and transmits sensory information to the neocortex. The activity of thalamocortical relay (TC) cells is modulated by specific inhibitory circuits.
Nevian, Thomas, Sieber, Andrea Rahel, Sieber, Andrea, Min, Rogier   +3 more
core   +1 more source

Air Pollution and the Risk and Progression of Multiple Sclerosis: A Systematic Review and Meta‐Analysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose Air pollution has been linked to several neurological conditions, including stroke and neurodegenerative diseases. Evidence regarding its association with multiple sclerosis (MS) remains conflicting, limited by small sample sizes. Methods PubMed, Embase, Scopus, and Cochrane controlled register of trials (CENTRAL) were searched on ...
Ahmad A. Toubasi, Thuraya N. Al‐Sayegh
wiley   +1 more source

Synaptic pruning following NMDAR-dependent LTD preferentially affects isolated synapses

iScience
Summary: Long-term depression (LTD) is an activity-dependent decrease in synaptic strength. This state initiates either a re-potentiation or a loss, aka pruning, of the synapse within hours to days following its induction.
Côme Camus, Léa Leval, Viviana Villicana-Munoz, Sarka Jelinkova, Benjamin Compans, Frédéric Gambino, Etienne Herzog, Daniel Choquet, Eric Hosy   +8 more
doaj   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

Lumbar spinal Shox2 interneurons receive monosynaptic excitatory input from the lateral paragigantocellular nucleus in mouse

iScience
Summary: Locomotion in vertebrates is generated in the spinal cord but initiated by supraspinal centers. Spinal interneurons expressing Shox2 include putative locomotor rhythm generating neurons in mice.
Shayna Singh, Lihua Yao, Kimberly J. Dougherty   +2 more
doaj   +1 more source

Protective effects of tamoxifen and raloxifene on apoptosis and oxidative stress in the kidney and liver of ovariectomized rats

, 2020
In the postmenopausal period, women undergo physical and morphological changes that may result in insufficiency and deterioration in physiological functions. It is accepted that oxidative stress is involved in the etiology of postmenopausal changes.
Yener YAZĞAN, Yazğan, Yener, Yazğan, Betül, Betül YAZĞAN   +3 more
core   +1 more source

Dysregulation of Synaptic and Developmental Transcriptomic/Proteomic Profiles upon Depletion of MUNC18-1

, 2022
Absence of presynaptic protein MUNC18-1 (gene: Stxbp1) leads to neuronal cell death at an immature stage before synapse formation. Here, we performed transcriptomic and proteomic profiling of immature Stxbp1 knock-out (KO) cells to discover which ...
Lammertse, Hanna C.A., Koopmans, Frank; id_orcid, Feringa, Femke, Van Berkel, Annemiek A., Verhage, Matthijs, Lammertse, Hanna C.A.; id_orcid, Gonzalez-Lozano, Miguel Angel; id_orcid, Lammertse, Hanna C. A., Sullivan, Patrick F., Gonzalez-Lozano, Miguel Angel, Feringa, Femke; id_orcid, Smit, August B., Toonen, Ruud F.; id_orcid, Koopmans, Frank, Toonen, Ruud F., Bryois, Julien   +15 more
core   +1 more source

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source