Results 71 to 80 of about 431,276 (246)

Functional Connectivity Linked to Cognitive Recovery After Minor Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri, Isabella Dallasta, Ciaran Stone, Sophia Girgenti, Neda Gould, Rafael H. Llinas, Jonathan Z. Simon, Elisabeth Breese Marsh   +7 more
wiley   +1 more source

Divergent Effects of Metformin on an Inflammatory Model of Parkinson’s Disease [PDF]

, 2018
The oral antidiabetic drug metformin is known to exhibit anti-inflammatory properties through activation of AMP kinase, thus protecting various brain tissues as cortical neurons, for example. However, the effect of metformin on the substantia nigra (SN),
Boza-Serrano, Antonio,, de Pablos, Rocío M.,, Deierborg, Tomas,, Espinosa-Oliva, Ana M.,, García-Domínguez, Irene,, Herrera, Antonio J.,, Ismaiel, Afrah Abdul,, Lund University., Lund University., Machado, Alberto,, Tayara, Khadija,, Venero, José L.,   +11 more
core   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

LPLAT11/MBOAT7-driven phosphatidylinositol remodeling ensures radial glial cell integrity in developing neocortex

iScience
Summary: Phosphatidylinositol (PI) is highly enriched in arachidonic acid, an essential polyunsaturated fatty acid for brain development. This enrichment is mediated by the phospholipid remodeling enzyme lysophospholipid acyltransferase 11 (LPLAT11 ...
Yuki Ishino, Yusuke Kishi, Taiga Iwama, Naohiro Kuwayama, Hiroyuki Arai, Yukiko Gotoh, Junken Aoki, Nozomu Kono   +7 more
doaj   +1 more source

Combined Cyclosporin A and Hypothermia Treatment Inhibits Activation of BV-2 Microglia but Induces an Inflammatory Response in an Ischemia/Reperfusion Hippocampal Slice Culture Model [PDF]

, 2019
Introduction: Hypothermia attenuates cerebral ischemia-induced neuronal cell death associated with neuroinflammation. The calcineurin inhibitor cyclosporin A (CsA) has been shown to be neuroprotective by minimizing activation of inflammatory pathways.
Berger, Felix, Krech, Jana, Rolfs, Nele, Schmitt, Katharina R. L., Tong, Giang, Wowro, Sylvia J.   +5 more
core   +1 more source

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source

Bipolar cell networks underlying steady-state intensity encoding in intrinsically photosensitive retinal ganglion cells

iScience
Summary: Intrinsically photosensitive retinal ganglion cells (ipRGCs) encode ambient light intensity at steady-state and drive physiology even in the absence of melanopsin, but the synaptic basis of such encoding remains unclear.
Shai Sabbah, Carin Papendorp, Inbar Behrendt, Hala Rasras, Jesse Cann, Megan L. Leyrer, Elizabeth Koplas, Marjo Beltoja, Cameron Etebari, Ali Noel Gunesch, Luis Carrete, Min Tae Kim, Gabrielle Manoff, Ananya Bhatia-Lin, Tiffany Zhao, Henry Dowling, Kevin L. Briggman, David M. Berson   +17 more
doaj   +1 more source

Songbird organotypic culture as an in vitro model for interrogating sparse sequencing networks [PDF]

, 2017
Sparse sequences of neuronal activity are fundamental features of neural circuit computation; however, the underlying homeostatic mechanisms remain poorly understood. To approach these questions, we have developed a method for cellular-resolution imaging
Blute, Todd, Cruz-Martin, Alberto, Gardner, Timothy, Kotten, Darrell N., Liberti, Derek C., Liberti, William A., III, Shen, Jun, Yen, William   +7 more
core   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source