Results 51 to 60 of about 244,397 (293)

New observations in neuroscience using superresolution microscopy

, 2019
© 2018 the authors. Superresolution microscopy (SM) techniques are among the revolutionary methods for molecular and cellular observations in the 21st century.
Barna, László, Nozumi, Motohiro, Zhang, Mingshu, Xue, Fudong, Wu, Ling-Gang, Cella Zanacchi, Francesca, Xu, Pingyong, Igarashi, Michihiro, Katona, István, Boyden, Edward   +9 more
core   +2 more sources

Pre- and postsynaptic N-methyl-D-aspartate receptors are required for sequential printing of fear memory engrams

iScience, 2023
Summary: The organization of fear memory involves the participation of multiple brain regions. However, it is largely unknown how fear memory is formed, which circuit pathways are used for “printing” memory engrams across brain regions, and the role of ...
Ilaria Bertocchi, Florbela Rocha-Almeida, María Teresa Romero-Barragán, Marco Cambiaghi, Alejandro Carretero-Guillén, Paolo Botta, Godwin K. Dogbevia, Mario Treviño, Paolo Mele, Alessandra Oberto, Matthew E. Larkum, Agnes Gruart, Rolf Sprengel, José Maria Delgado-García, Mazahir T. Hasan   +14 more
doaj   +1 more source

The road ahead in clinical network neuroscience

, 2019
Clinical network neuroscience, the study of brain network topology in neurological and psychiatric diseases, has become a mainstay field within clinical neuroscience.
van den Heuvel, Martijn, Senden, Mario, Hillebrand, Arjan, Senden, Mario; id_orcid, van Straaten, Elisabeth C.W., de Haan, Willem, Stam, Cornelis J., Nissen, Ida A., Tijms, Betty M., van Straaten, Elisabeth C. W., Griffa, Alessandra, Otte, Willem M., Reijmer, Yael D., van Dellen, Edwin, Tewarie, Prejaas, Gouw, Alida A., Douw, Linda, Van Mieghem, Piet, Schoonheim, Menno M.   +18 more
core   +1 more source

A Markerless Pose Estimator Applicable to Limbless Animals

, 2022
The analysis of kinematics, locomotion, and spatial tasks relies on the accurate detection of animal positions and pose. Pose and position can be assessed with video analysis programs, the “trackers.” Most available trackers represent animals as single ...
Göpfert, Martin C.; 1Department of Cellular Neuroscience, Georg-August-University Göttingen, Gottingen, Germany, Göpfert, Martin C., Garg, Vranda; 1Department of Cellular Neuroscience, Georg-August-University Göttingen, Gottingen, Germany, André, Selina, Geurten, Bart R. H., Heyer, Luisa; 1Department of Cellular Neuroscience, Georg-August-University Göttingen, Gottingen, Germany, Geurten, Bart R. H.; 1Department of Cellular Neuroscience, Georg-August-University Göttingen, Gottingen, Germany, Garg, Vranda, Heyer, Luisa, Dosch, Roland; 2Institute for Humangenetics, University Medical Center Göttingen, Georg-August-University Göttingen, Gottingen, Germany, Dosch, Roland, Giraldo, Diego, André, Selina; 1Department of Cellular Neuroscience, Georg-August-University Göttingen, Gottingen, Germany, Giraldo, Diego; 1Department of Cellular Neuroscience, Georg-August-University Göttingen, Gottingen, Germany   +13 more
core   +1 more source

Regulatory role of phospholipase A2 inhibitor in oxidative stress and inflammation induced by an experimental mouse migraine model

, 2023
Migraine is a complex neurological problem whose primary symptom is headache and is common in the human population. It is well known that neuroinflammation plays a vital role in the pathogenesis of migraine, with adverse effects on the nervous system ...
Yener YAZĞAN, Yazğan, Yener, Betül YAZĞAN, Yazğan, Betül   +3 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Effects of sub-chronic exposure of male albino rats to some insecticides on mitochondrial dysfunction and oxidative stress in the kidney with molecular docking

, 2022
The present study evaluated the adverse effects of three widely used insecticides in the Egyptian environment on mitochondrial bioenergetic and oxidative stress biomarkers in the rat kidney.
Mohamed BADAWY, Younis, Hassan, Abdel-razik, Reda, Mahmoud ABO-EL-SAAD, Hassan YOUNİS, Badawy, Mohamed, Taha, Mostafa, Mostafa TAHA, Reda ABDEL-RAZİK, Abo-el-saad, Mahmoud   +9 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Schwann cell to axon transfer of ribosomes: toward a novel understanding of the role of glia in the nervous system [PDF]

, 2008
Schwann cells play pivotal roles in the development and maintenance of the peripheral nervous system. Here, we show that intact sciatic nerve axons of mice contain a small population of ribosomes, which increases by several orders of magnitude when axons
Mac Gillavry, H.D., F. A. Court, W. T. J. Hendriks, van Minnen, J., H. D. MacGillavry, Minnen, J. van, J. Alvarez, J. van Minnen, Hendriks, W.T.J., Court, W.A., Van Winnen, J., Hendriks, W.T., Alvarez, J., Alvarez, J., Court, F.A., Macgillavry, H.D.   +15 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source