Results 51 to 60 of about 1,766,854 (293)

Scn2a insufficiency alters spontaneous neuronal Ca2+ activity in somatosensory cortex during wakefulness

iScience, 2023
Summary: SCN2A protein-truncating variants (PTV) can result in neurological disorders such as autism spectrum disorder and intellectual disability, but they are less likely to cause epilepsy in comparison to missense variants.
Melody Li, Mohamed Eltabbal, Hoang-Dai Tran, Bernd Kuhn   +3 more
doaj   +1 more source

Cellular and chemical neuroscience of mammalian sleep [PDF]

Sleep Medicine, 2010
Extraordinary strides have been made toward understanding the complexities and regulatory mechanisms of sleep over the past two decades thanks to the help of rapidly evolving technologies. At its most basic level, mammalian sleep is a restorative process of the brain and body.
openaire   +2 more sources

Programmable DNA Nanodevices for Applications in Neuroscience

, 2021
The broad area of neuroscience has witnessed an increasing exploitation of a variety of synthetic biomaterials with controlled nanosized features. Different bionanomaterials offer very peculiar physicochemical and biochemcial properties contributing to ...
Hivare, Pravin, Panda, Chinmaya, Sharad Gupta, Gupta, Sharad, Pravin Hivare, Chinmaya Panda, Dhiraj Bhatia, Bhatia, Dhiraj   +7 more
core   +1 more source

Selective dysfunction of fast-spiking inhibitory interneurons and disruption of perineuronal nets in a tauopathy mouse model

iScience, 2023
Summary: In Alzheimer’s disease (AD), network hyperexcitability is frequently observed and associated with subsequent cognitive impairment. Dysfunction of inhibitory interneurons (INs) is thought to be one of the key biological mechanisms of ...
Takehiro Kudo, Hiroyuki Takuwa, Manami Takahashi, Takuya Urushihata, Masafumi Shimojo, Kazuaki Sampei, Mitsugu Yamanaka, Yutaka Tomita, Naruhiko Sahara, Tetsuya Suhara, Makoto Higuchi   +10 more
doaj   +1 more source

The road ahead in clinical network neuroscience

, 2019
Clinical network neuroscience, the study of brain network topology in neurological and psychiatric diseases, has become a mainstay field within clinical neuroscience.
van den Heuvel, Martijn, Senden, Mario, Hillebrand, Arjan, Senden, Mario; id_orcid, van Straaten, Elisabeth C.W., de Haan, Willem, Stam, Cornelis J., Nissen, Ida A., Tijms, Betty M., van Straaten, Elisabeth C. W., Griffa, Alessandra, Otte, Willem M., Reijmer, Yael D., van Dellen, Edwin, Tewarie, Prejaas, Gouw, Alida A., Douw, Linda, Van Mieghem, Piet, Schoonheim, Menno M.   +18 more
core   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Sparse memory ensembles set brain-wide network states to sustain learned associations

iScience
Summary: The ability to recall spatial memories and adapt behavior to changing conditions underlies efficient navigation. These processes are thought to rely on sparse populations of neurons, embedded within distributed brain networks. Here, we sought to
Josué Haubrich, Gabriele Russo, Denise Manahan-Vaughan   +2 more
doaj   +1 more source

Neural activation associated with outgroup helping in adolescent rats

iScience, 2022
Summary: Prosocial behavior, helping others in need in particular, occurs preferentially in response to the perceived distress of one’s own group members or ingroup.
Jocelyn M. Breton, Jordan S. Eisner, Vaidehi S. Gandhi, Natalie Musick, Aileen Zhang, Kimberly L.P. Long, Olga S. Perloff, Kelsey Y. Hu, Chau M. Pham, Pooja Lalchandani, Matthew K. Barraza, Ben Kantor, Daniela Kaufer, Inbal Ben-Ami Bartal   +13 more
doaj   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Regional specialization of the tongue revealed by gustatory ganglion imaging

iScience, 2022
Summary: Gustatory information is relayed from the anterior tongue by geniculate ganglion neurons and from the posterior tongue by neurons of the petrosal portion of the jugular/nodose/petrosal ganglion complex.
Bryan E. Fowler, Jiahao Ye, Saima Humayun, Hojoon Lee, Lindsey J. Macpherson   +4 more
doaj   +1 more source