Results 41 to 50 of about 1,766,854 (293)

Neonatal exposures to sevoflurane in rhesus monkeys alter synaptic ultrastructure in later life

iScience, 2022
Summary: Repeated or prolonged early life exposure to anesthesia is neurotoxic in animals and associated with neurocognitive impairment in later life in humans.
Tristan Fehr, William G.M. Janssen, Janis Park, Mark G. Baxter   +3 more
doaj   +1 more source

Neuroscience Needs Network Science [PDF]

, 2023
The brain is a complex system comprising a myriad of interacting neurons, posing significant challenges in understanding its structure, function, and dynamics.
Bullmore, E, Sporns, O, Kovács, IA, Hernán Makse, Christos Papadimitriou, Albert-László Barabási, György Buzsáki, Hongkui Zeng, Bianconi, G, Ed Bullmore, Zador, AM, Tina Eliassi-Rad, Thomas E. Nichols, Towlson, EK, Zeng, H, Anthony M. Zador, Buzsáki, G, Kim Stachenfeld, Burgess, M, Nichols, TE, Olaf Sporns, Amy Bernard, Barabási, DL, Dileep George, Emma K. Towlson, Bernard, A, Stachenfeld, K, Mark Burgess, SueYeon Chung, Zoltán Toroczkai, Chung, S, Dániel L. Barabási, George, D, Ginestra Bianconi, Eliassi-Rad, T, István A. Kovács, Makse, H, Barabási, A-L, Toroczkai, Z, Papadimitriou, C, Chung, Sue Yeon, Kovács, István A., Papadimitriou, Christos, Zador, Anthony M., Makse, Hernán, Stachenfeld, Kim, Bianconi, Ginestra, Zeng, Hongkui, Nichols, Thomas E., Bullmore, Ed, Bernard, Amy, Eliassi-Rad, Tina, Burgess, Mark, Sporns, Olaf, Barabási, Dániel L., George, Dileep, Toroczkai, Zoltán, Buzsáki, György, Barabási, Albert László, Towlson, Emma K.   +59 more
core   +1 more source

Ablation of Ventral Midbrain/Pons GABA Neurons Induces Mania-like Behaviors with Altered Sleep Homeostasis and Dopamine D2R-mediated Sleep Reduction

iScience, 2020
Summary: Individuals with the neuropsychiatric disorder mania exhibit hyperactivity, elevated mood, and a decreased need for sleep. The brain areas and neuronal populations involved in mania-like behaviors, however, have not been elucidated.
Takato Honda, Yohko Takata, Yoan Cherasse, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa, Michael Lazarus, Yo Oishi   +9 more
doaj   +1 more source

Miami Neuroscience Institute - Winter 2021

, 2021
https://scholarlycommons.baptisthealth.net/bg-bh-neuroscience-news/1004/thumbnail ...
Miami Neuroscience Institute
core   +1 more source

Antidepressant Effects of (S)-Ketamine through a Reduction of Hyperpolarization-Activated Current Ih

iScience, 2020
Summary: Compelling evidence suggests that a single sub-anesthetic dose of (R,S)-ketamine exerts rapid and robust antidepressant effects. However, the cellular mechanisms underlying the antidepressant effects of (R,S)-ketamine remain unclear.
Chung Sub Kim, Daniel Johnston
doaj   +1 more source

Targeting PTEN but not SOCS3 resists an age-dependent decline in promoting axon sprouting

iScience, 2022
Summary: Axonal repair is critical for functional recovery after injury of the CNS. We previously reported that neuronal PTEN deletion exhibits an age-dependent decline in promoting axon regeneration from the corticospinal tract (CST).
Cédric G. Geoffroy, Jessica M. Meves, Hugo Jae Mun Kim, Daniel Romaus-Sanjurjo, Theresa C. Sutherland, Jeffrey J. Li, Juliet Suen, Joshua J. Sanchez, Binhai Zheng   +8 more
doaj   +1 more source

Harnessing the potential of cellular, animal and computational neuroscience models for mental health

, 2023
Landscaping report exploring the potential for cellular, animal and computational neuroscience models, individually and in combination, to make meaningful contributions to our understanding and early intervention of anxiety, depression, and psychosis.
Xiaosi Gu (17179219), Deepak Srivastava (17179224), Rosalyn Moran (17179220), Mark Walton (12551174)   +3 more
core   +1 more source

The Accumulation of Tau-Immunoreactive Hippocampal Granules and Corpora Amylacea Implicates Reactive Glia in Tau Pathogenesis during Aging

iScience, 2020
Summary: The microtubule-associated tau protein forms pathological inclusions that accumulate in an age-dependent manner in tauopathies including Alzheimer's disease (AD). Since age is the major risk factor for AD, we examined endogenous tau species that
Connor M. Wander, Jui-Heng Tseng, Sheng Song, Heba A. Al Housseiny, Dalton S. Tart, Aditi Ajit, Yen-Yu Ian Shih, Rebecca Lobrovich, Juan Song, Rick B. Meeker, David J. Irwin, Todd J. Cohen   +11 more
doaj   +1 more source

Activity-dependent tau cleavage by caspase-3 promotes neuronal dysfunction and synaptotoxicity

iScience, 2023
Summary: Tau-mediated toxicity is associated with cognitive decline and Alzheimer’s disease (AD) progression. In particular, tau post-translational modifications (PTMs) are thought to generate aberrant tau species resulting in neuronal dysfunction ...
Carli K. Opland, Miles R. Bryan, Braxton Harris, Jake McGillion-Moore, Xu Tian, Youjun Chen, Michelle S. Itano, Graham H. Diering, Rick B. Meeker, Todd J. Cohen   +9 more
doaj   +1 more source

Substantia nigra modulates breathing rate via locus coeruleus

iScience
Summary: Breathing is an automatic and rhythmic act primarily controlled by hindbrain neural circuits, including the pre-Bötzinger complex. While the basal ganglia are known to regulate a wide range of behaviors through downstream projections, their role
Bon-Mi Gu, Jae Gon Kim, Aronee Hossain, Greg O. Cron, Jin Hyung Lee   +4 more
doaj   +1 more source