Results 31 to 40 of about 230,098 (152)

The Accumulation of Tau-Immunoreactive Hippocampal Granules and Corpora Amylacea Implicates Reactive Glia in Tau Pathogenesis during Aging

iScience, 2020
Summary: The microtubule-associated tau protein forms pathological inclusions that accumulate in an age-dependent manner in tauopathies including Alzheimer's disease (AD). Since age is the major risk factor for AD, we examined endogenous tau species that
Connor M. Wander, Jui-Heng Tseng, Sheng Song, Heba A. Al Housseiny, Dalton S. Tart, Aditi Ajit, Yen-Yu Ian Shih, Rebecca Lobrovich, Juan Song, Rick B. Meeker, David J. Irwin, Todd J. Cohen   +11 more
doaj   +1 more source

Distinct synaptic pools of DAPK1 differentially regulate activity-dependent synaptic CaMKII accumulation

iScience, 2023
Summary: The death-associated protein kinase 1 (DAPK1) regulates the synaptic movement of the Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII).
Jonathan E. Tullis, K. Ulrich Bayer
doaj   +1 more source

Substantia nigra modulates breathing rate via locus coeruleus

iScience
Summary: Breathing is an automatic and rhythmic act primarily controlled by hindbrain neural circuits, including the pre-Bötzinger complex. While the basal ganglia are known to regulate a wide range of behaviors through downstream projections, their role
Bon-Mi Gu, Jae Gon Kim, Aronee Hossain, Greg O. Cron, Jin Hyung Lee   +4 more
doaj   +1 more source

Feeding neurons integrate metabolic and reproductive states in mice

iScience, 2023
Summary: Balance between metabolic and reproductive processes is important for survival, particularly in mammals that gestate their young. How the nervous system coordinates this balance is an active area of study.
Megan G. Massa, Rachel L. Scott, Alexandra L. Cara, Laura R. Cortes, Paul B. Vander, Norma P. Sandoval, Jae W. Park, Sahara L. Ali, Leandro M. Velez, Huei-Bin Wang, Shomik S. Ati, Bethlehem Tesfaye, Karen Reue, J. Edward van Veen, Marcus M. Seldin, Stephanie M. Correa   +15 more
doaj   +1 more source

Generation of self-organized autonomic ganglion organoids from fibroblasts

iScience, 2023
Summary: Neural organoids have been shown to serve as powerful tools for studying the mechanism of neural development and diseases as well as for screening drugs and developing cell-based therapeutics. Somatic cells have previously been reprogrammed into
Shuting Liu, Kangjian Xiang, Fa Yuan, Mengqing Xiang   +3 more
doaj   +1 more source

Female mice lacking GluA3 show early onset of hearing loss, cochlear synaptopathy, and afferent terminal swellings in ambient sound levels

iScience
Summary: AMPA-type glutamate receptors (AMPARs) mediate excitatory cochlear transmission. However, unique roles of AMPAR subunits are unresolved. Lack of subunit GluA3 (Gria3KO) in male mice reduced cochlear output by 8 postnatal weeks.
Indra Pal, Atri Bhattacharyya, Babak V-Ghaffari, Essence Devine Williams, Maolei Xiao, Mark Allen Rutherford, María Eulalia Rubio   +6 more
doaj   +1 more source

Neonatal exposures to sevoflurane in rhesus monkeys alter synaptic ultrastructure in later life

iScience, 2022
Summary: Repeated or prolonged early life exposure to anesthesia is neurotoxic in animals and associated with neurocognitive impairment in later life in humans.
Tristan Fehr, William G.M. Janssen, Janis Park, Mark G. Baxter   +3 more
doaj   +1 more source

Moderate Changes in CO2 Modulate the Firing of Neurons in the VTA and Substantia Nigra

iScience, 2020
Summary: The substantia nigra (SN) and ventral tegmental area (VTA) are vital for the control of movement, goal-directed behavior, and encoding reward.
Emily Hill, Nicholas Dale, Mark J. Wall
doaj   +1 more source

Targeting PTEN but not SOCS3 resists an age-dependent decline in promoting axon sprouting

iScience, 2022
Summary: Axonal repair is critical for functional recovery after injury of the CNS. We previously reported that neuronal PTEN deletion exhibits an age-dependent decline in promoting axon regeneration from the corticospinal tract (CST).
Cédric G. Geoffroy, Jessica M. Meves, Hugo Jae Mun Kim, Daniel Romaus-Sanjurjo, Theresa C. Sutherland, Jeffrey J. Li, Juliet Suen, Joshua J. Sanchez, Binhai Zheng   +8 more
doaj   +1 more source

Activity-dependent tau cleavage by caspase-3 promotes neuronal dysfunction and synaptotoxicity

iScience, 2023
Summary: Tau-mediated toxicity is associated with cognitive decline and Alzheimer’s disease (AD) progression. In particular, tau post-translational modifications (PTMs) are thought to generate aberrant tau species resulting in neuronal dysfunction ...
Carli K. Opland, Miles R. Bryan, Braxton Harris, Jake McGillion-Moore, Xu Tian, Youjun Chen, Michelle S. Itano, Graham H. Diering, Rick B. Meeker, Todd J. Cohen   +9 more
doaj   +1 more source