Results 31 to 40 of about 1,766,854 (293)

Glucokinase neurons of the paraventricular nucleus of the thalamus sense glucose and decrease food consumption

iScience, 2021
Summary: The paraventricular nucleus of the thalamus (PVT) controls goal-oriented behavior through its connections to the nucleus accumbens (NAc). We previously characterized Glut2aPVT neurons that are activated by hypoglycemia, and which increase ...
Sébastien Kessler, Gwenaël Labouèbe, Sophie Croizier, Sevasti Gaspari, David Tarussio, Bernard Thorens   +5 more
doaj   +1 more source

Bridging molecular and cellular neuroscience with proximity labeling technologies. [PDF]

Exp Mol Med
Abstract Proximity labeling (PL) techniques have advanced neuroscience by revealing the molecular interactions that govern neural circuits. From foundational tools such as BioID and APEX to recent innovations such as TurboID and light-activated systems, PL enables precise mapping of protein–protein interactions within living cells.
Lee JG, Jeong I, Kim KE.
europepmc   +3 more sources

Intracellular Ca2+ dynamics in the ALA neuron reflect sleep pressure and regulate sleep in Caenorhabditis elegans

iScience, 2022
Summary: The mechanisms underlying sleep homeostasis are poorly understood. The nematode Caenorhabditis elegans exhibits 2 types of sleep: lethargus, or developmentally timed, and stress-induced sleep.
Shinichi Miyazaki, Taizo Kawano, Masashi Yanagisawa, Yu Hayashi   +3 more
doaj   +1 more source

Anatomical organization of temporally correlated neural calcium activity in the hippocampal CA1 region

iScience, 2023
Summary: Hippocampal CA1 neuronal ensembles generate sequential patterns of firing activity that contribute to episodic memory formation and spatial cognition. Here we used in vivo calcium imaging to record neural ensemble activities in mouse hippocampal
Lujia Chen, Xiaoxiao Lin, Qiao Ye, Zoran Nenadic, Todd C. Holmes, Douglas A. Nitz, Xiangmin Xu   +6 more
doaj   +1 more source

Red Light Optogenetics in Neuroscience

, 2022
Optogenetics, a field concentrating on controlling cellular functions by means of light-activated proteins, has shown tremendous potential in neuroscience.
Lehtinen, Kimmo, Nokia, Miriam S., Takala, Heikki, Heikki Takala, Kimmo Lehtinen, Miriam S. Nokia   +5 more
core   +1 more source

Neuroscience of alcoholism: molecular and cellular mechanisms [PDF]

Cellular and Molecular Life Sciences, 2009
Alcohol use and abuse appear to be related to neuroadaptive changes at functional, neurochemical, and structural levels. Acute and chronic ethanol exposure have been shown to modulate function of the activity-dependent gene transcription factor, cAMP-responsive element binding (CREB) protein in the brain, which may be associated with the development of
Sachin, Moonat, Bela G, Starkman, Amul, Sakharkar, Subhash C, Pandey   +3 more
openaire   +2 more sources

Behavioral observation of xenopus tadpole swimming for neuroscience labs [PDF]

, 2014
Neuroscience labs benefit from reliable, easily - monitored neural responses mediated by well - studied neural pathways . Xenopus laevis tadpoles have been used as a simple vertebrate model preparation in motor control studies.
Porter, Nicola Jean, Li, Wenchang, Wagner, Monica Anne   +2 more
core   +2 more sources

Impaired synaptic plasticity in an animal model of autism exhibiting early hippocampal GABAergic-BDNF/TrkB signaling alterations

iScience, 2023
Summary: In Neurodevelopmental Disorders, alterations of synaptic plasticity may trigger structural changes in neuronal circuits involved in cognitive functions.
Martina Sgritta, Beatrice Vignoli, Domenico Pimpinella, Marilena Griguoli, Spartaco Santi, Andrzej Bialowas, Grzegorz Wiera, Paola Zacchi, Francesca Malerba, Cristina Marchetti, Marco Canossa, Enrico Cherubini   +11 more
doaj   +1 more source

Glycine-induced NMDA receptor internalization provides neuroprotection and preserves vasculature following ischemic stroke

iScience, 2022
Summary: Ischemic stroke is the second leading cause of death worldwide. Following an ischemic event, neuronal death is triggered by uncontrolled glutamate release leading to overactivation of glutamate sensitive N-methyl-d-aspartate receptor (NMDAR ...
Julia Cappelli, Pamela Khacho, Boyang Wang, Alexandra Sokolovski, Wafae Bakkar, Sophie Raymond, Nina Ahlskog, Julian Pitney, Junzheng Wu, Prakash Chudalayandi, Adrian Y.C. Wong, Richard Bergeron   +11 more
doaj   +1 more source

Primary cilia are required for the persistence of memory and stabilization of perineuronal nets

iScience, 2021
Summary: It is well established that the formation of episodic memories requires multiple hippocampal mechanisms operating on different time scales.
Vladimir Jovasevic, Hui Zhang, Farahnaz Sananbenesi, Anita L. Guedea, Kizhake V. Soman, John E. Wiktorowicz, Andre Fischer, Jelena Radulovic   +7 more
doaj   +1 more source