Results 31 to 40 of about 230,455 (251)

Targeting PTEN but not SOCS3 resists an age-dependent decline in promoting axon sprouting

iScience, 2022
Summary: Axonal repair is critical for functional recovery after injury of the CNS. We previously reported that neuronal PTEN deletion exhibits an age-dependent decline in promoting axon regeneration from the corticospinal tract (CST).
Cédric G. Geoffroy, Jessica M. Meves, Hugo Jae Mun Kim, Daniel Romaus-Sanjurjo, Theresa C. Sutherland, Jeffrey J. Li, Juliet Suen, Joshua J. Sanchez, Binhai Zheng   +8 more
doaj   +1 more source

The Accumulation of Tau-Immunoreactive Hippocampal Granules and Corpora Amylacea Implicates Reactive Glia in Tau Pathogenesis during Aging

iScience, 2020
Summary: The microtubule-associated tau protein forms pathological inclusions that accumulate in an age-dependent manner in tauopathies including Alzheimer's disease (AD). Since age is the major risk factor for AD, we examined endogenous tau species that
Connor M. Wander, Jui-Heng Tseng, Sheng Song, Heba A. Al Housseiny, Dalton S. Tart, Aditi Ajit, Yen-Yu Ian Shih, Rebecca Lobrovich, Juan Song, Rick B. Meeker, David J. Irwin, Todd J. Cohen   +11 more
doaj   +1 more source

Activity-dependent tau cleavage by caspase-3 promotes neuronal dysfunction and synaptotoxicity

iScience, 2023
Summary: Tau-mediated toxicity is associated with cognitive decline and Alzheimer’s disease (AD) progression. In particular, tau post-translational modifications (PTMs) are thought to generate aberrant tau species resulting in neuronal dysfunction ...
Carli K. Opland, Miles R. Bryan, Braxton Harris, Jake McGillion-Moore, Xu Tian, Youjun Chen, Michelle S. Itano, Graham H. Diering, Rick B. Meeker, Todd J. Cohen   +9 more
doaj   +1 more source

Scn2a insufficiency alters spontaneous neuronal Ca2+ activity in somatosensory cortex during wakefulness

iScience, 2023
Summary: SCN2A protein-truncating variants (PTV) can result in neurological disorders such as autism spectrum disorder and intellectual disability, but they are less likely to cause epilepsy in comparison to missense variants.
Melody Li, Mohamed Eltabbal, Hoang-Dai Tran, Bernd Kuhn   +3 more
doaj   +1 more source

Substantia nigra modulates breathing rate via locus coeruleus

iScience
Summary: Breathing is an automatic and rhythmic act primarily controlled by hindbrain neural circuits, including the pre-Bötzinger complex. While the basal ganglia are known to regulate a wide range of behaviors through downstream projections, their role
Bon-Mi Gu, Jae Gon Kim, Aronee Hossain, Greg O. Cron, Jin Hyung Lee   +4 more
doaj   +1 more source

Selective dysfunction of fast-spiking inhibitory interneurons and disruption of perineuronal nets in a tauopathy mouse model

iScience, 2023
Summary: In Alzheimer’s disease (AD), network hyperexcitability is frequently observed and associated with subsequent cognitive impairment. Dysfunction of inhibitory interneurons (INs) is thought to be one of the key biological mechanisms of ...
Takehiro Kudo, Hiroyuki Takuwa, Manami Takahashi, Takuya Urushihata, Masafumi Shimojo, Kazuaki Sampei, Mitsugu Yamanaka, Yutaka Tomita, Naruhiko Sahara, Tetsuya Suhara, Makoto Higuchi   +10 more
doaj   +1 more source

Neural activation associated with outgroup helping in adolescent rats

iScience, 2022
Summary: Prosocial behavior, helping others in need in particular, occurs preferentially in response to the perceived distress of one’s own group members or ingroup.
Jocelyn M. Breton, Jordan S. Eisner, Vaidehi S. Gandhi, Natalie Musick, Aileen Zhang, Kimberly L.P. Long, Olga S. Perloff, Kelsey Y. Hu, Chau M. Pham, Pooja Lalchandani, Matthew K. Barraza, Ben Kantor, Daniela Kaufer, Inbal Ben-Ami Bartal   +13 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Sparse memory ensembles set brain-wide network states to sustain learned associations

iScience
Summary: The ability to recall spatial memories and adapt behavior to changing conditions underlies efficient navigation. These processes are thought to rely on sparse populations of neurons, embedded within distributed brain networks. Here, we sought to
Josué Haubrich, Gabriele Russo, Denise Manahan-Vaughan   +2 more
doaj   +1 more source

Regional specialization of the tongue revealed by gustatory ganglion imaging

iScience, 2022
Summary: Gustatory information is relayed from the anterior tongue by geniculate ganglion neurons and from the posterior tongue by neurons of the petrosal portion of the jugular/nodose/petrosal ganglion complex.
Bryan E. Fowler, Jiahao Ye, Saima Humayun, Hojoon Lee, Lindsey J. Macpherson   +4 more
doaj   +1 more source