Results 21 to 30 of about 244,298 (194)

Reflections on the past two decades of neuroscience [PDF]

, 2020
The first issue of Nature Reviews Neuroscience was published 20 years ago, in 2000. To mark this anniversary, in this Viewpoint article we asked a selection of researchers from across the field who have authored pieces published in the journal in recent ...
Bassett, Danielle S., Cullen, Kathleen E, Eickhoff, Simon B., Hu, Hailan, Prinz, Marco, Ueda, Hiroki R., Eickhoff, Simon B, Poldrack, Russell A, Bassett, Danielle S, Poirazi, Panayiota, Khakh, Baljit S., Cullen, Kathleen E., Roelfsema, Pieter R., Knoblich, Jurgen A, Spires-Jones, Tara, Roelfsema, Peiter R, Hurd, Yasmin L., Haggard, Patrick, Josselyn, Sheena A., Knoblich, Jürgen A., Josselyn, Sheena A, Ueda, Hiroki R, Khakh, Baljit S, Farah, Martha J, Hurd, Yasmin L, Spires-Jones, Tara L., Poldrack, Russell A., Sur, Mriganka, Goda, Yukiko, Farah, Martha J.   +29 more
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Mu-opioid receptor selective superagonists produce prolonged respiratory depression

iScience, 2023
Summary: Synthetic opioids are increasingly challenging to combat the opioid epidemic and act primarily at opioid receptors, chiefly the G protein-coupled receptor (GPCR) μ-opioid receptor (MOR), which signals through G protein-dependent and β-arrestin ...
Nicholas J. Malcolm, Barbara Palkovic, Daniel J. Sprague, Maggie M. Calkins, Janelle K. Lanham, Adam L. Halberstadt, Astrid G. Stucke, John D. McCorvy   +7 more
doaj   +1 more source

Casein kinase 1α is required to maintain murine hypothalamic pro-opiomelanocortin expression

iScience, 2023
Summary: Hypothalamic pro-opiomelanocortin (POMC) neuron development is considered to play an essential role in the development of obesity. However, the underlying mechanisms remain unclear.
Chenyang Lu, Jinglin Zhang, Bingjie Wang, Qiao Gao, Kezhe Ma, Shaona Pei, Juxue Li, Sheng Cui   +7 more
doaj   +1 more source

Multiscale Neuroscience of Psychiatric Disorders [PDF]

, 2019
The human brain comprises a multiscale network with multiple levels of organization. Neurons with dendritic and axonal connections form the microscale fabric of brain circuitry, and macroscale brain regions and white matter connections form the ...
van den Heuvel, Martijn, Scholtens, Lianne H, Kahn, Rene, van den Heuvel, Martijn P, Scholtens, Lianne, van den Heuvel, Martijn P., Scholtens, Lianne H., Scholtens, Lianne; id_orcid, Kahn, René S., Kahn, René S   +9 more
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Ablation of Ventral Midbrain/Pons GABA Neurons Induces Mania-like Behaviors with Altered Sleep Homeostasis and Dopamine D2R-mediated Sleep Reduction

iScience, 2020
Summary: Individuals with the neuropsychiatric disorder mania exhibit hyperactivity, elevated mood, and a decreased need for sleep. The brain areas and neuronal populations involved in mania-like behaviors, however, have not been elucidated.
Takato Honda, Yohko Takata, Yoan Cherasse, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi, Hiromasa Funato, Masashi Yanagisawa, Michael Lazarus, Yo Oishi   +9 more
doaj   +1 more source

Red Light Optogenetics in Neuroscience

, 2022
Optogenetics, a field concentrating on controlling cellular functions by means of light-activated proteins, has shown tremendous potential in neuroscience.
Lehtinen, Kimmo, Nokia, Miriam S., Takala, Heikki   +2 more
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Statistical power in network neuroscience [PDF]

, 2023
Network neuroscience has emerged as a leading method to study brain connectivity. The success of these investigations is dependent not only on approaches to accurately map connectivity but also on the ability to detect real effects in the data - that is,
Helwegen, Koen, Libedinsky, Ilan, van den Heuvel, Martijn P.   +2 more
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Antidepressant Effects of (S)-Ketamine through a Reduction of Hyperpolarization-Activated Current Ih

iScience, 2020
Summary: Compelling evidence suggests that a single sub-anesthetic dose of (R,S)-ketamine exerts rapid and robust antidepressant effects. However, the cellular mechanisms underlying the antidepressant effects of (R,S)-ketamine remain unclear.
Chung Sub Kim, Daniel Johnston
doaj   +1 more source

Potent antioxidant alpha lipoic acid reduces STZ-induced oxidative stress and apoptosis levels in the erythrocytes and brain cells of diabetic rats

, 2023
Diabetes, which causes oxidative stress-induced neuronal damage, is still one of the most important chronic health problems in the world. It can cause serious cellular loss and damage throughout the course of the disease.
Yener YAZĞAN, Yazğan, Yener, Yazğan, Betül, Betül YAZĞAN   +3 more
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Hyperexcitable Parvalbumin Interneurons Render Hippocampal Circuitry Vulnerable to Amyloid Beta

iScience, 2020
Summary: Parvalbumin (PV) interneuron dysfunction is associated with various brain disorders, including Alzheimer disease (AD). Here, we asked whether early PV neuron hyperexcitability primes the hippocampus for amyloid beta-induced functional impairment.
Sara Hijazi, Tim S. Heistek, Rolinka van der Loo, Huibert D. Mansvelder, August B. Smit, Ronald E. van Kesteren   +5 more
doaj   +1 more source