Results 21 to 30 of about 431,276 (246)

Impaired synaptic plasticity in an animal model of autism exhibiting early hippocampal GABAergic-BDNF/TrkB signaling alterations

iScience, 2023
Summary: In Neurodevelopmental Disorders, alterations of synaptic plasticity may trigger structural changes in neuronal circuits involved in cognitive functions.
Martina Sgritta, Beatrice Vignoli, Domenico Pimpinella, Marilena Griguoli, Spartaco Santi, Andrzej Bialowas, Grzegorz Wiera, Paola Zacchi, Francesca Malerba, Cristina Marchetti, Marco Canossa, Enrico Cherubini   +11 more
doaj   +1 more source

Mechanisms of sensorineural cell damage, death and survival in the cochlea. [PDF]

, 2015
The majority of acquired hearing loss, including presbycusis, is caused by irreversible damage to the sensorineural tissues of the cochlea. This article reviews the intracellular mechanisms that contribute to sensorineural damage in the cochlea, as well ...
Ryan, Allen F, Wong, Ann CY
core   +1 more source

Glycogenolysis Is Crucial for Astrocytic Glycogen Accumulation and Brain Damage after Reperfusion in Ischemic Stroke

iScience, 2020
Summary: Astrocytic glycogen is an important energy reserve in the brain and is believed to supply fuel during energy crisis. However, the pattern of glycogen metabolism in ischemic stroke and its potential therapeutic impact on neurological outcomes are
Yanhui Cai, Haiyun Guo, Ze Fan, Xinlei Zhang, Di Wu, Wenhong Tang, Tingting Gu, Shiquan Wang, Anqi Yin, Liang Tao, Xunming Ji, Hailong Dong, Yan Li, Lize Xiong   +13 more
doaj   +1 more source

Glycine-induced NMDA receptor internalization provides neuroprotection and preserves vasculature following ischemic stroke

iScience, 2022
Summary: Ischemic stroke is the second leading cause of death worldwide. Following an ischemic event, neuronal death is triggered by uncontrolled glutamate release leading to overactivation of glutamate sensitive N-methyl-d-aspartate receptor (NMDAR ...
Julia Cappelli, Pamela Khacho, Boyang Wang, Alexandra Sokolovski, Wafae Bakkar, Sophie Raymond, Nina Ahlskog, Julian Pitney, Junzheng Wu, Prakash Chudalayandi, Adrian Y.C. Wong, Richard Bergeron   +11 more
doaj   +1 more source

Sphingolipids as emerging mediators in retina degeneration [PDF]

, 2019
The sphingolipids ceramide (Cer), sphingosine-1-phosphate (S1P), sphingosine (Sph), and ceramide-1-phosphate (C1P) are key signaling molecules that regulate major cellular functions.
Prado Spalm, Facundo Heber, Rotstein, Nora Patricia, Simon, Maria Victoria, Vera, Marcela Sonia   +3 more
core   +1 more source

Primary cilia are required for the persistence of memory and stabilization of perineuronal nets

iScience, 2021
Summary: It is well established that the formation of episodic memories requires multiple hippocampal mechanisms operating on different time scales.
Vladimir Jovasevic, Hui Zhang, Farahnaz Sananbenesi, Anita L. Guedea, Kizhake V. Soman, John E. Wiktorowicz, Andre Fischer, Jelena Radulovic   +7 more
doaj   +1 more source

VCP-dependent muscle degeneration is linked to defects in a dynamic tubular lysosomal network in vivo. [PDF]

, 2015
Lysosomes are classically viewed as vesicular structures to which cargos are delivered for degradation. Here, we identify a network of dynamic, tubular lysosomes that extends throughout Drosophila muscle, in vivo. Live imaging reveals that autophagosomes
Davis, Graeme W, Hauswirth, Anna G, Johnson, Alyssa E, Shu, Huidy, Tong, Amy   +4 more
core   +3 more sources

Identification of early-onset photoreceptor degeneration in transgenic mouse models of Alzheimer's disease

iScience, 2021
Summary: Light sensitivity of the vertebrate retina relies on the integrity of photoreceptors, including rods and cones. Research in patients with Alzheimer's disease (AD) and in AD transgenic mice reports that accumulated amyloid-β (Aβ) plaques in the ...
Jie Zhang, Feng Gao, Yuqian Ma, Tian Xue, Yong Shen   +4 more
doaj   +1 more source

Neural mechanisms of social learning in the female mouse [PDF]

, 2017
Social interactions are often powerful drivers of learning. In female mice, mating creates a long-lasting sensory memory for the pheromones of the stud male that alters neuroendocrine responses to his chemosignals for many weeks.
Abraham, Abraham, Arnson, Bakker, Barkai, Barth, Ben-Shaul, Brennan, Brennan, Brennan, Brennan, Brennan, Brennan, Bruce, Burns-Cusato, Caligioni, Castro, Chamero, Clancy, Daoudal, Desai, Dietz, Dulac, Dulac, Fan, Guenthner, Halem, Harvey, Hendrickson, Hull, Hurst, Ichikawa, Isaacson, Kaba, Kaba, Kendrick, Keverne, Kimchi, Lee, Li, Lin, Luo, Lévy, Mak, Margrie, Matsuoka, Matsuoka, Matsuoka, Meeks, Mozzachiodi, Nolan, Nolan, Preston, Reijmers, Reijmers, Ross, Rosser, Sakurai, Shepherd, Shingo, Shpak, Shpak, Stackman, Stowers, Ström, Tachikawa, Takahashi, Tirindelli, Tolokh, Turrigiano, Wallace, Wang, Wang, Wang, Wu, Yassin, Yiu, Young, Zhang, Zhou   +79 more
core   +1 more source

Retinal glial remodeling by FGF21 preserves retinal function during photoreceptor degeneration

iScience, 2021
Summary: The group of retinal degenerations, retinitis pigmentosa (RP), comprises more than 150 genetic abnormalities affecting photoreceptors. Finding degenerative pathways common to all genetic abnormalities may allow general treatment such as ...
Zhongjie Fu, Chenxi Qiu, Gael Cagnone, Yohei Tomita, Shuo Huang, Bertan Cakir, Yumi Kotoda, William Allen, Edward Bull, James D. Akula, Jean-Sébastien Joyal, Ann Hellström, Saswata Talukdar, Lois E.H. Smith   +13 more
doaj   +1 more source