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Debugging cellular reprogramming
Nature Cell Biology, 2007Last year it was reported that a cocktail of four transcription factors — encoded by Oct4, Sox2, Myc and Klf4 — can partly reprogramme mouse somatic cells to an embryonic state, a process that reawakens silenced segments of the genome and restores pluripotency to the somatic cell nucleus.
In-Hyun Park, George Q. Daley
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Cellular Reprogramming During Mouse Development
2012States of terminal cell differentiation are often considered to be fixed. There are examples, however, in which cells of one type can be converted to a completely different cell type. The process whereby one cell type can be converted to another is referred to as cellular reprogramming.
Zoë D, Burke +2 more
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2006
The concept of reprogramming a cell is very intriguing and has immense therapeutic potential. Examples from physiology and developmental biology suggest that it may well be possible. Experimental approaches are beginning to suggest this also, in particular the initially astonishing accomplishment of somatic cell nuclear transfer and cloning.
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The concept of reprogramming a cell is very intriguing and has immense therapeutic potential. Examples from physiology and developmental biology suggest that it may well be possible. Experimental approaches are beginning to suggest this also, in particular the initially astonishing accomplishment of somatic cell nuclear transfer and cloning.
openaire +2 more sources
Detecting Cellular Senescence in Reprogramming
2018Cellular senescence has been suggested to facilitate tissue regeneration via promoting cellular plasticity. Here, we describe multiple systems, both in vitro and in vivo, to detect senescence in the context of cellular reprogramming.
Cazin, Coralie +2 more
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Therapeutic Cloning and Cellular Reprogramming
2012Embryonic stem cells are capable of differentiating into any cell-type present in an adult organism, and constitute a renewable source of tissue for regenerative therapies. The transplant of allogenic stem cells is challenging due to the risk of immune rejection.
Ramon M, Rodriguez +2 more
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Cellular Reprogramming and Aging
2020In this chapter, we will discuss how aging impacts the dynamics of stem cells and affects cellular reprogramming. We will discuss certain pathways involved in the aging process, and how we can use those pathways to increase the efficiency of the reprogramming protocol.
Sandrina Nóbrega-Pereira +1 more
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SOX17 in cellular reprogramming and cancer
Seminars in Cancer Biology, 2020SOX17 is a transcription factor directing the specification and development of the primitive endoderm, primitive germ cells, definitive endoderm and, subsequently, is involved in the cardiovascular system and several endoderm-derived organs. The analysis of cancer genome sequencing data classified SOX17 as mutated cancer driver gene in endometrial ...
Daisylyn Senna, Tan +4 more
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Epigenetics, cardiovascular disease, and cellular reprogramming
Journal of Molecular and Cellular Cardiology, 2019Under the seeming disorder of "junk" sequences the last decade has seen developments in our understanding of non-coding RNA's (ncRNAs). It's a complex revised order and nowhere is this more relevant than in the developing heart whereby old rules have been set aside to make room for new ones.
Keith, Al-Hasani +2 more
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Cellular reprogramming to reset epigenetic signatures
Molecular Aspects of Medicine, 2013The controlled differentiation of induced pluripotent stem cells (iPSC) towards clinically-relevant cell types has benefitted from epigenetic profiling of lineage-specific markers to confirm the phenotype of iPSC-derived cells. Mapping epigenetic marks throughout the genome has identified unique changes which occur in the DNA methylation profile of ...
Kyle J, Hewitt, Jonathan A, Garlick
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High-efficiency cellular reprogramming with microfluidics
Nature Methods, 2016We report that the efficiency of reprogramming human somatic cells to induced pluripotent stem cells (hiPSCs) can be dramatically improved in a microfluidic environment. Microliter-volume confinement resulted in a 50-fold increase in efficiency over traditional reprogramming by delivery of synthetic mRNAs encoding transcription factors.
LUNI, CAMILLA +10 more
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