Results 1 to 10 of about 210,068 (196)

Young at Heart: Pioneering Approaches to Model Nonischaemic Cardiomyopathy with Induced Pluripotent Stem Cells [PDF]

Stem Cells International, 2016
A mere 9 years have passed since the revolutionary report describing the derivation of induced pluripotent stem cells from human fibroblasts and the first in-patient translational use of cells obtained from these stem cells has already been achieved ...
Aoife Gowran, Marco Rasponi, Roberta Visone, Patrizia Nigro, Gianluca L. Perrucci, Stefano Righetti, Marco Zanobini, Giulio Pompilio   +7 more
doaj   +5 more sources

An efficient platform for astrocyte differentiation from human induced pluripotent stem cells [PDF]

, 2017
Summary: Growing evidence implicates the importance of glia, particularly astrocytes, in neurological and psychiatric diseases. Here, we describe a rapid and robust method for the differentiation of highly pure populations of replicative astrocytes from ...
Abdelaal, Rawan, Bowles, Kathryn R, Brennand, Kristen J, Goate, Alison M, Hartley, Brigham J, Karch, Celeste M, Lacin, Emre, Machlovi, Saima I, Phatnani, Hemali, Pimenova, Anna A, Slesinger, Paul A, TCW, Julia, Wang, Minghui, Zhang, Bin   +13 more
core   +15 more sources

Recent Developments in Clinical Applications of Mesenchymal Stem Cells in the Treatment of Rheumatoid Arthritis and Osteoarthritis

Frontiers in Immunology, 2021
Mesenchymal stem cell (MSC) therapies have been used as cell-based treatments for decades, owing to their anti-inflammatory, immunomodulatory, and regenerative properties.
Joel Jihwan Hwang, Yeri Alice Rim, Yoojun Nam, Ji Hyeon Ju, Ji Hyeon Ju   +4 more
doaj   +1 more source

Pathogenic Role of Circulating Citrullinated Antigens and Anti-Cyclic Monoclonal Citrullinated Peptide Antibodies in Rheumatoid Arthritis

Frontiers in Immunology, 2021
We examined whether it is possible to directly detect citrullinated antigens in the serum of rheumatoid arthritis (RA) patients using a monoclonal antibody (mAb) designed to be specific for citrullinated peptides. In order to confirm the potential of the
Pureun Won, Pureun Won, Youngkyun Kim, Youngkyun Kim, Youngkyun Kim, Hyerin Jung, Hyerin Jung, Yeri Alice Rim, Yeri Alice Rim, Dong Hyun Sohn, Dong Hyun Sohn, Dong Hyun Sohn, William H. Robinson, William H. Robinson, Su-Jin Moon, Ji Hyeon Ju, Ji Hyeon Ju, Ji Hyeon Ju   +17 more
doaj   +1 more source

Pluripotency of induced pluripotent stem cells [PDF]

Journal of Animal Science and Biotechnology, 2012
Recent studies have demonstrated that differentiated somatic cells from various mammalian species can be reprogrammed into induced pluripotent stem (iPS) cells by the ectopic expression of four transcription factors that are highly expressed in embryonic stem (ES) cells.
Kang Lan, Gao Shaorong
openaire   +3 more sources

Naïve-like pluripotency to pave the way for saving the northern white rhinoceros from extinction

Scientific Reports, 2022
The northern white rhinoceros (NWR) is probably the earth’s most endangered mammal. To rescue the functionally extinct species, we aim to employ induced pluripotent stem cells (iPSCs) to generate gametes and subsequently embryos in vitro.
Vera Zywitza, Ejona Rusha, Dmitry Shaposhnikov, Jorge Ruiz-Orera, Narasimha Telugu, Valentyna Rishko, Masafumi Hayashi, Geert Michel, Lars Wittler, Jan Stejskal, Susanne Holtze, Frank Göritz, Robert Hermes, Jichang Wang, Zsuzsanna Izsvák, Silvia Colleoni, Giovanna Lazzari, Cesare Galli, Thomas B. Hildebrandt, Katsuhiko Hayashi, Sebastian Diecke, Micha Drukker   +21 more
doaj   +1 more source

Cell reprogramming shapes the mitochondrial DNA landscape

Nature Communications, 2021
Here the authors describe high depth mitochondrial DNA (mtDNA) sequence analysis of 146 human induced pluripotent stem cell (hiPSC) lines as well as single cell RNA-seq (scRNAseq) of hiPSCs undergoing differentiation from 125 donors; reporting mtDNA ...
Wei Wei, Daniel J. Gaffney, Patrick F. Chinnery   +2 more
doaj   +1 more source

Induced pluripotent stem cells are induced pluripotent stem cell-like cells [PDF]

The Journal of Biomedical Research, 2015
Gold is rare and precious, while pyrite (FeS2) is abundant and cheap. Pyrite is nicknamed fool's gold, since pyrite looks like gold and it is even shinier and brighter than gold. It is very difficult to recognize the differences between a real natural gold and a gold-like rock (pyrite) to non-professional persons[1], but we know that all that glitters ...
Song, Liting, Goldman, Emanuel
openaire   +2 more sources

Immunogenicity of Induced Pluripotent Stem Cells [PDF]

Circulation Research, 2011
### Immunogenicity of Induced Pluripotent Stem Cells Zhao et al Nature . 2011. doi:10.1038/nature10135 A new study shows the immunogenicity of induced pluripotent stem cells by the direct transplantation of undifferentiated cells into syngenic mice.
Keisuke, Okita, Naoki, Nagata, Shinya, Yamanaka   +2 more
openaire   +5 more sources

Induced Pluripotent Stem Cells

Chinese medical journal, 2011
Induced pluripotent stem (iPS) cells are a recent development which has brought a promise of great therapeutic values. The previous technique of somatic cell nuclear transfer (SCNT) has been ineffective in humans. Recent discoveries show that human fibroblasts can be reprogrammed by a transient over expression of a small number of genes; they can ...
Keisuke Okita, Shinya Yamanaka
  +8 more sources