Results 1 to 10 of about 1,403,431 (298)

Production and characterization of human induced pluripotent stem cells (iPSC) CSSi007-A (4383) from Joubert Syndrome

Stem Cell Research, 2019
Joubert syndrome (JS) is an autosomal recessive neurodevelopmental disorder, characterized by congenital cerebellar and brainstem defects, belonging to the group of disorders known as ciliopathies, which are caused by mutations in genes encoding proteins
Filomena Altieri, Angela D'Anzi, Francesco Martello, Silvia Tardivo, Iolanda Spasari, Daniela Ferrari, Laura Bernardini, Giuseppe Lamorte, Gianluigi Mazzoccoli, Enza Maria Valente, Angelo Luigi Vescovi, Jessica Rosati   +11 more
doaj   +1 more source

Advances in Liquid Biopsy for Diagnosis of Bladder Cancer [PDF]

International Neurourology Journal
Bladder cancer (BCa) is the most common malignancy of the urinary system. It has a high recurrence rate and requires longterm follow-up. Significant advances in BCa research have been made in recent years; however, the initial diagnosis and follow-up of ...
Jaekwon Seok, Yeonjoo Kwak, Sewhan Kim, Eun-Mee Kim, Aram Kim   +4 more
doaj   +1 more source

Intercellular transfer of cancer cell invasiveness via endosome-mediated protease shedding

Nature Communications
Overexpression of the transmembrane matrix metalloproteinase MT1-MMP/MMP14 promotes cancer cell invasion. Here we show that MT1-MMP-positive cancer cells turn MT1-MMP-negative cells invasive by transferring a soluble catalytic ectodomain of MT1-MMP ...
Eva Maria Wenzel, Nina Marie Pedersen, Liv Anker Elfmark, Ling Wang, Ingrid Kjos, Espen Stang, Lene Malerød, Andreas Brech, Harald Stenmark, Camilla Raiborg   +9 more
doaj   +1 more source

Therapeutic potential of NGF-enriched extracellular vesicles in modulating neuroinflammation and enhancing peripheral nerve remyelination

Acta Neuropathologica Communications
Neurological damage caused by peripheral nerve injury can be devastating and is a common neurological disorder that, along with muscle disorders, reduces the quality of life.
Hancheol Yeo, Yoo Jung Kim, Jaekwon Seok, Yeonjoo Kwak, Soo Bin Jang, Na Hee Lim, Kwonwoo Song, Junghoon Lee, Min Chul Cho, Soo Woong Kim, Ssang-Goo Cho   +10 more
doaj   +1 more source

Cellular reprogramming and hepatocellular carcinoma development

World Journal of Gastroenterology, 2013
Hepatocellular carcinoma (HCC) is one of the most common cancers, and is also the leading cause of death worldwide. Studies have shown that cellular reprogramming contributes to chemotherapy and/or radiotherapy resistance and the recurrence of cancers.
Yun-Wen, Zheng, Yun-Zhong, Nie, Hideki, Taniguchi   +2 more
openaire   +2 more sources

Generation and characterization of the hiPSC line CSSi023-A (16154) from a patient with ADOA caused by an OPA1 variant

Stem Cell Research
Autosomal Dominant Optic Atrophy plus syndrome (ADOA, OMIM #125250) is a mitochondrial optic neuropathy characterized by progressive degeneration of retinal ganglion cells (RGCs), leading to worsening visual impairment.
Angela Maria Giada Giovenale, Ilaria Ferrone, Silvia Tomaselli, Elisa Maria Turco, Martina Mazzoni, Barbara Torres, Paola Zanfardino, Edvige Vulcano, Daniela Ferrari, Devid Damiani, Filippo M. Santorelli, Alessandro De Luca, Maria Pennuto, Angelo Luigi Vescovi, Vittoria Petruzzella, Jessica Diana Rosati   +15 more
doaj   +1 more source

Mechanochemically primed regenerative extracellular vesicles as a nanotherapeutic strategy for peripheral neuropathy

Journal of Nanobiotechnology
Background Peripheral neuropathy is a chronic neurological disorder characterized by inflammation, nerve damage, and impaired function. It arises owing to various factors, including traumatic nerve injury, neuropathic pain due to cancer, and diabetic ...
Yeonjoo Kwak, Hye Min Jeun, Han Cheol Yeo, Sang-Hyeon Nam, Min-Ju Lee, Sujin Yu, Hyung Seok Choi, Ye Ji Han, Kwonwoo Song, Mi-Sook Chang, Ssang-Goo Cho   +10 more
doaj   +1 more source

Generation of induced pluripotent stem cells (CSSi017-A)(12862) from an ALS patient carrying a repeat expansion in the C9orf72 gene

Stem Cell Research
Genetic expansions of the hexanucleotide repeats (GGGGCC) in the C9orf72 gene appear in approximately 40% of patients with familial ALS and 7% of patients with sporadic ALS in the European population, making this mutation one of the most prevalent ...
G. Ruotolo, A. D'Anzi, A. Casamassa, M. Mazzoni, D. Ferrari, I. Lombardi, R.M. Carletti, C. D'Asdia, I. Torrente, K. Frezza, S. Lattante, M. Sabatelli, M. Pennuto, A.L. Vescovi, J. Rosati   +14 more
doaj   +1 more source

Ultrasound-triggered three dimensional hyaluronic acid hydrogel promotes in vitro and in vivo reprogramming into induced pluripotent stem cells

Bioactive Materials
Cellular reprogramming technologies have been developed with different physicochemical factors to improve the reprogramming efficiencies of induced pluripotent stem cells (iPSCs). Ultrasound is a clinically applied noncontact biophysical factor known for
Deogil Kim, Min-Ju Lee, Yoshie Arai, Jinsung Ahn, Gun Woo Lee, Soo-Hong Lee   +5 more
doaj   +1 more source

Collective processes in cellular reprogramming

, 2023
Epigenetics comprises chemical modifications of the DNA and the proteins that the DNA is wrapped around them. These modifications play key roles in establishing and maintaining cellular identity throughout development and adulthood. In recent years, it has become increasingly clear that these actions are more dynamic than initially believed.
openaire   +2 more sources