Results 41 to 50 of about 1,403,431 (298)
Cells, 2022 Autophagy is a highly conserved lysosomal degradation pathway active at basal levels in all cells. However, under stress conditions, such as a lack of nutrients or trophic factors, it works as a survival mechanism that allows the generation of metabolic ...
Laura Gómez-Virgilio +11 more
doaj +1 more source
Transcriptional reprogramming in cellular quiescence [PDF]
RNA Biology, 2017 Most cells in nature are not actively dividing, yet are able to return to the cell cycle given the appropriate environmental signals. There is now ample evidence that quiescent G0 cells are not shut-down but still metabolically and transcriptionally active.
Roche, Benjamin +2 more
openaire +2 more sources
Journal of Animal Reproduction and Biotechnology, 2018 Hedgehog (Hh) pathway plays a key role in development from invertebrate to vertebrate. It is known to be involved in cell differentiation, polarity, proliferation, including the development of vertebrate limb and the establishment of flies’ body plan. To
Jaehyun Park +4 more
doaj +1 more source
Partial cellular reprogramming: A deep dive into an emerging rejuvenation technology [PDF]
Aging CellAlejandro Ocampo, Patrick Paine
exaly +2 more sources
Small Molecules Pushing Erythroid/Megakaryocyte Cell Specification Boundaries
, 2022 A combination of a MEK/ERK-signaling inhibitor and three chromatin-remodeling molecules enhances generation of platelet-producing megakaryocytes in vitro, possibly through direct ...
Flygare, Johan,, Lund University.
core +1 more source
GENERATION OF MOUSE INDUCED PLURIPOTENT STEM CELLS BY PROTEIN TRANSDUCTION. [PDF]
, 2013 Somatic cell reprogramming has generated enormous interest after the first report by Yamanaka and his coworkers in 2006 on the generation of induced pluripotent stem cells (iPSCs) from mouse fibroblasts. Here we report the generation of stable iPSCs from
Polgár, Zsuzsanna +5 more
core +1 more source
Molecular Roadblocks for Cellular Reprogramming [PDF]
Molecular Cell, 2012 During development, diverse cellular identities are established and maintained in the embryo. Although remarkably robust in vivo, cellular identities can be manipulated using experimental techniques. Lineage reprogramming is an emerging field at the intersection of developmental and stem cell biology in which a somatic cell is stably reprogrammed into ...
Vierbuchen, Thomas, Wernig, Marius
openaire +2 more sources
Cellular reprogramming and cancer development [PDF]
International Journal of Cancer, 2012 AbstractCancer develops through the accumulation of genetic and epigenetic abnormalities. The role of genetic alterations in cancer development has been demonstrated by reverse genetic approaches. However, evidence indicating the functional significance of epigenetic abnormalities remains limited due to the lack of means to actively modify coordinated ...
Katsunori, Semi +3 more
openaire +2 more sources
The Journal of Reproduction and DevelopmentThe enzymatic isolation of preantral follicles (PAFs) is considered the most efficient method for retrieving a large number of intact follicles, offering significant advantages in terms of yield and processing time.
Ba Anh My LE +10 more
doaj +1 more source
Journal of Animal Reproduction and Biotechnology, 2018 Polo-like kinase 1 (Plk1) has been known to be a critical element in cell division including centrosome maturation, cytokinesis and spindle formation in somatic, cancer, and mammalian embryonic cells.
Jeonghyeon Moon, Sangho Roh
doaj +1 more source