Results 51 to 60 of about 1,403,431 (298)

Cellular Reprogramming in Pursuit of Immortality [PDF]

Cell Stem Cell, 2012
The discovery that phenotypic diversity among differentiated cells results from epigenetic and not genetic differences, and can be reset to restore pluripotency, promises revolutionary advances in medicine. I discuss how this and related seminal discoveries have brought us to an exciting future.
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Cellular Reprogramming [PDF]

Circulation: Heart Failure, 2013
The hearts of lower vertebrates have remarkable regenerative capacity.1 Neonatal mouse hearts are also capable of repairing damaged myocardium; however, this capacity is lost barely 2 weeks after birth.2 The human adult myocardium is replenished throughout life,3 and studies suggest that this occurs as a result of division of existing cardiomyocytes,4 ...
Anthony J, White, Deevina, Arasaratnam, David A, Elliott, David M, Kaye   +3 more
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Improving porcine in vitro blastocyst development using fetal bovine serum, amino acids, and insulin-transferrin-selenium

The Journal of Reproduction and Development
In vitro production of porcine-hatched blastocysts is important for various applications. However, the mechanobiology of blastocoel expansion and hatching remains poorly understood.
Ba Anh My LE, Lien Boi Linh NGUYEN, Chi Thien LAM, Nhat-Thinh NGUYEN, Ngoc Thao Vy NGUYEN, Van Thuan NGUYEN, Hong-Thuy BUI   +6 more
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Molecular versatility during pluripotency progression

Nature Communications, 2023
During development the embryo must balance lineage specification against the preservation of plasticity using a limited molecular toolkit. In this Perspective, the authors propose Molecular Versatility as a paradigm for grouping molecular mechanisms that
Giacomo Furlan, Aurélia Huyghe, Noémie Combémorel, Fabrice Lavial   +3 more
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Generation of an induced pluripotent stem cell line (CSS012-A (7672)) carrying the p.G376D heterozygous mutation in the TARDBP protein

Stem Cell Research, 2021
Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative condition with phenotypic and genetic heterogeneity. It is characterized by the selective vulnerability and the progressive loss of the neural population.
Angela D'Anzi, Filomena Altieri, Elisa Perciballi, Daniela Ferrari, Barbara Torres, Laura Bernardini, Serena Lattante, Mario Sabatelli, Angelo Luigi Vescovi, Jessica Rosati   +9 more
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DIrect Cellular Reprogramming: The Hopes and the Hurdles [PDF]

European Journal of Heart Failure, 2016
Comment on Direct cellular reprogramming for cardiac repair and regeneration.
SINAGRA, GIANFRANCO, FABRIS, ENRICO
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Nuclear reprogramming: kinetics of cell cycle and metabolic progression as determinants of success [PDF]

, 2012
Establishment of totipotency after somatic cell nuclear transfer (NT) requires not only reprogramming of gene expression, but also conversion of the cell cycle from quiescence to the precisely timed sequence of embryonic cleavage.
Franchesca Dawn Houghton (171722), Tsurumi Chizuko, Martin Johannes Pfeiffer (171732), Kanzler, Benoit, Fuellen, Georg, Pfeiffer, M., Tsurumi, Chizuko, Siatkowski Marcin, Benoit Kanzler (171742), Boiani, Michele, Esteves, T., Fuellen, G., Michele Boiani, Houghton, F., Georg Fuellen, Esteves Telma Cristina, Pfeiffer, Martin Johannes, Fuellen Georg, Balbach, S., Kanzler, B., Esteves, Telma Cristina, Benoit Kanzler, Kanzler Benoit, Boiani Michele, Telma Cristina Esteves, Michele Boiani (171751), Siatkowski, Marcin, Houghton Franchesca Dawn, Marcin Siatkowski, Balbach, Sebastian Thomas, Boiani, M., Georg Fuellen (16022), Telma Cristina Esteves (171719), Marcin Siatkowski (171726), Franchesca Dawn Houghton, Sebastian Thomas Balbach (171715), Chizuko Tsurumi (171736), Pfeiffer Martin Johannes, Siatkowski, M., Houghton, Franchesca Dawn, Martin Johannes Pfeiffer, Chizuko Tsurumi, Balbach Sebastian Thomas, Tsurumi, C., Sebastian Thomas Balbach   +44 more
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Comparison of Developmental Efficiency of Murine Somatic Cell Nuclear Transfer Protocol

Journal of Animal Reproduction and Biotechnology, 2017
The Somatic cell nuclear transfer (SCNT) method can be applied to various fields such as species conservation, regenerative medicine, farming industries and drug production. However, the efficiency using SCNT is very low for many reasons.
Jeonghyeon Moon, Miran Jung, Sangho Roh
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A Highly Optimized Protocol for Reprogramming Cancer Cells to Pluripotency Using Nonviral Plasmid Vectors

, 2015
In spite of considerable interest in the field, reprogramming induced pluripotent stem cells (iPSCs) directly from cancer cells has encountered considerable challenges, including the extremely low reprogramming efficiency and instability of cancer ...
Huang, FP, Ning, J, Davies, TJ, Fairchild, PJ, Sachamitr, P, Zhao, HZ, Chang, Y, Sattler, S   +7 more
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Generation of induced pluripotent stem cells (iPSC) from an atrial fibrillation patient carrying a KCNA5 p.D322H mutation

Stem Cell Research, 2017
Atrial fibrillation (AF) is the most common sustained arrhythmia associated with several cardiac risk factors, but increasing evidences indicated a genetic component.
Cristina Mora, Marialaura Serzanti, Alessio Giacomelli, Valentina Turco, Eleonora Marchina, Valeria Bertini, Giovanna Piovani, Giulia Savio, Lena Refsgaard, Morten Salling Olesen, Venusia Cortellini, Patrizia Dell'Era   +11 more
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