Results 31 to 40 of about 154,639 (265)

Improving porcine in vitro blastocyst development using fetal bovine serum, amino acids, and insulin-transferrin-selenium

The Journal of Reproduction and Development
In vitro production of porcine-hatched blastocysts is important for various applications. However, the mechanobiology of blastocoel expansion and hatching remains poorly understood.
Ba Anh My LE, Lien Boi Linh NGUYEN, Chi Thien LAM, Nhat-Thinh NGUYEN, Ngoc Thao Vy NGUYEN, Van Thuan NGUYEN, Hong-Thuy BUI   +6 more
doaj   +1 more source

Molecular versatility during pluripotency progression

Nature Communications, 2023
During development the embryo must balance lineage specification against the preservation of plasticity using a limited molecular toolkit. In this Perspective, the authors propose Molecular Versatility as a paradigm for grouping molecular mechanisms that
Giacomo Furlan, Aurélia Huyghe, Noémie Combémorel, Fabrice Lavial   +3 more
doaj   +1 more source

Cellular reprogramming and cancer development [PDF]

International Journal of Cancer, 2012
AbstractCancer develops through the accumulation of genetic and epigenetic abnormalities. The role of genetic alterations in cancer development has been demonstrated by reverse genetic approaches. However, evidence indicating the functional significance of epigenetic abnormalities remains limited due to the lack of means to actively modify coordinated ...
Katsunori, Semi, Yutaka, Matsuda, Kotaro, Ohnishi, Yasuhiro, Yamada   +3 more
openaire   +2 more sources

Generation of an induced pluripotent stem cell line (CSS012-A (7672)) carrying the p.G376D heterozygous mutation in the TARDBP protein

Stem Cell Research, 2021
Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative condition with phenotypic and genetic heterogeneity. It is characterized by the selective vulnerability and the progressive loss of the neural population.
Angela D'Anzi, Filomena Altieri, Elisa Perciballi, Daniela Ferrari, Barbara Torres, Laura Bernardini, Serena Lattante, Mario Sabatelli, Angelo Luigi Vescovi, Jessica Rosati   +9 more
doaj   +1 more source

Cellular Reprogramming in Pursuit of Immortality [PDF]

Cell Stem Cell, 2012
The discovery that phenotypic diversity among differentiated cells results from epigenetic and not genetic differences, and can be reset to restore pluripotency, promises revolutionary advances in medicine. I discuss how this and related seminal discoveries have brought us to an exciting future.
openaire   +2 more sources

DIrect Cellular Reprogramming: The Hopes and the Hurdles [PDF]

European Journal of Heart Failure, 2016
Comment on Direct cellular reprogramming for cardiac repair and regeneration.
SINAGRA, GIANFRANCO, FABRIS, ENRICO
openaire   +3 more sources

Comparison of Developmental Efficiency of Murine Somatic Cell Nuclear Transfer Protocol

Journal of Animal Reproduction and Biotechnology, 2017
The Somatic cell nuclear transfer (SCNT) method can be applied to various fields such as species conservation, regenerative medicine, farming industries and drug production. However, the efficiency using SCNT is very low for many reasons.
Jeonghyeon Moon, Miran Jung, Sangho Roh
doaj   +1 more source

Generation of induced pluripotent stem cells (iPSC) from an atrial fibrillation patient carrying a KCNA5 p.D322H mutation

Stem Cell Research, 2017
Atrial fibrillation (AF) is the most common sustained arrhythmia associated with several cardiac risk factors, but increasing evidences indicated a genetic component.
Cristina Mora, Marialaura Serzanti, Alessio Giacomelli, Valentina Turco, Eleonora Marchina, Valeria Bertini, Giovanna Piovani, Giulia Savio, Lena Refsgaard, Morten Salling Olesen, Venusia Cortellini, Patrizia Dell'Era   +11 more
doaj   +1 more source

New Insights into X-Chromosome Reactivation during Reprogramming to Pluripotency

Cells, 2020
Dosage compensation between the sexes results in one X chromosome being inactivated during female mammalian development. Chromosome-wide transcriptional silencing from the inactive X chromosome (Xi) in mammalian cells is erased in a process termed X ...
Amitesh Panda, Jan J. Zylicz, Vincent Pasque   +2 more
doaj   +1 more source

Biomarker Candidates for Alzheimer’s Disease Unraveled through In Silico Differential Gene Expression Analysis

Diagnostics, 2022
Alzheimer’s disease (AD) is neurodegeneration that accounts for 60–70% of dementia cases. Symptoms begin with mild memory difficulties and evolve towards cognitive impairment.
Maria-del-Carmen Silva-Lucero, Jared Rivera-Osorio, Laura Gómez-Virgilio, Gustavo Lopez-Toledo, José Luna-Muñoz, Francisco Montiel-Sosa, Luis O. Soto-Rojas, Mar Pacheco-Herrero, Maria-del-Carmen Cardenas-Aguayo   +8 more
doaj   +1 more source