Results 31 to 40 of about 233,840 (301)
Lin28A induces energetic switching to glycolytic metabolism in human embryonic kidney cells [PDF]
, 2016 Background: Loss of a cell’s capacity to generate sufficient energy for cellular functions is a key hallmark of the ageing process and ultimately leads to a variety of important age-related pathologies such as cancer, Parkinson’s disease and ...
Docherty, Craig K. +2 more
core +3 more sources
Cellular reprogramming and cancer development [PDF]
International Journal of Cancer, 2012 AbstractCancer develops through the accumulation of genetic and epigenetic abnormalities. The role of genetic alterations in cancer development has been demonstrated by reverse genetic approaches. However, evidence indicating the functional significance of epigenetic abnormalities remains limited due to the lack of means to actively modify coordinated ...
Katsunori, Semi +3 more
openaire +2 more sources
MicroRNAs Are Indispensable for Reprogramming Mouse Embryonic Fibroblasts into Induced Stem Cell-Like Cells [PDF]
, 2012 MicroRNAs play a pivotal role in cellular maintenance, proliferation, and differentiation. They have also been implicated to play a key role in disease pathogenesis, and more recently, cellular reprogramming. Certain microRNA clusters can enhance or even
Choi, Michael Yoon-Suk +6 more
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Molecular Roadblocks for Cellular Reprogramming [PDF]
Molecular Cell, 2012 During development, diverse cellular identities are established and maintained in the embryo. Although remarkably robust in vivo, cellular identities can be manipulated using experimental techniques. Lineage reprogramming is an emerging field at the intersection of developmental and stem cell biology in which a somatic cell is stably reprogrammed into ...
Vierbuchen, Thomas, Wernig, Marius
openaire +2 more sources
Journal of Animal Reproduction and Biotechnology, 2018 Hedgehog (Hh) pathway plays a key role in development from invertebrate to vertebrate. It is known to be involved in cell differentiation, polarity, proliferation, including the development of vertebrate limb and the establishment of flies’ body plan. To
Jaehyun Park +4 more
doaj +1 more source
Reprogramming glioblastoma multiforme cells into neurons by protein kinase inhibitors [PDF]
, 2018 Background Reprogramming of cancers into normal-like tissues is an innovative strategy for cancer treatment. Recent reports demonstrate that defined factors can reprogram cancer cells into pluripotent stem cells. Glioblastoma multiforme (GBM) is the most
Hallahan, Dennis +7 more
core +2 more sources
Cellular Reprogramming in Pursuit of Immortality [PDF]
Cell Stem Cell, 2012 The discovery that phenotypic diversity among differentiated cells results from epigenetic and not genetic differences, and can be reset to restore pluripotency, promises revolutionary advances in medicine. I discuss how this and related seminal discoveries have brought us to an exciting future.
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GENERATION OF MOUSE INDUCED PLURIPOTENT STEM CELLS BY PROTEIN TRANSDUCTION. [PDF]
, 2013 Somatic cell reprogramming has generated enormous interest after the first report by Yamanaka and his coworkers in 2006 on the generation of induced pluripotent stem cells (iPSCs) from mouse fibroblasts. Here we report the generation of stable iPSCs from
Andras Dinnyes +6 more
core +1 more source
DIrect Cellular Reprogramming: The Hopes and the Hurdles [PDF]
European Journal of Heart Failure, 2016 Comment on Direct cellular reprogramming for cardiac repair and regeneration.
SINAGRA, GIANFRANCO, FABRIS, ENRICO
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Embryonic stem cell-specific signatures in cancer: insights into genomic regulatory networks and implications for medicine [PDF]
, 2011 Embryonic stem (ES) cells are of great interest as a model system for studying early developmental processes and because of their potential therapeutic applications in regenerative medicine.
Kim, Jonghwan, Orkin, Stuart
core +1 more source