Results 11 to 20 of about 233,840 (301)
An Algorithm for Cellular Reprogramming [PDF]
Proceedings of the National Academy of Sciences, 2017 The day we understand the time evolution of subcellular elements at a level of detail comparable to physical systems governed by Newton's laws of motion seems far away.
Bloch, Anthony +7 more
core +4 more sources
, 2009 DNA-methylatie is een epigenetische modificatie. Dit type van modificaties verandert de genetische informatie zelf niet, maar wijzigt de laag erboven. Er worden chemische modificaties toegevoegd of gewijzigd op het DNA of de histonen (waarrond het DNA ...
Ongenaert, Maté
core +3 more sources
Cellular reprogramming and epigenetic rejuvenation [PDF]
Clinical Epigenetics, 2021 AbstractAgeing is an inevitable condition that afflicts all humans. Recent achievements, such as the generation of induced pluripotent stem cells, have delivered preliminary evidence that slowing down and reversing the ageing process might be possible. However, these techniques usually involve complete dedifferentiation, i.e.
Daniel J. Simpson +2 more
openaire +3 more sources
Epigenetics of cellular reprogramming [PDF]
Current Opinion in Genetics & Development, 2013 Cells are constantly changing their state of equilibrium in response to internal and external stimuli. These changes in cell identity are driven by highly coordinated modulation of gene expression. This coordinated regulation is achieved in large part due to changes in the structure and composition of the chromatin, driven by epigenetic modulators ...
Krishnakumar, Raga, Blelloch, Robert H
openaire +4 more sources
DNA methylation and cellular reprogramming [PDF]
Trends in Cell Biology, 2010 The recent discovery that a small number of defined factors are sufficient to reprogram somatic cells into pluripotent stem cells has significantly expanded our knowledge of the plasticity of the epigenome. In this review we discuss some aspects of cell fate plasticity and epigenetic alterations, with emphasis on DNA methylation during cellular ...
Daniel D, De Carvalho +2 more
openaire +2 more sources
Decoding cancer etiology with cellular reprogramming. [PDF]
Curr Opin Genet DevCancer research remains clinically unmet in many areas due to limited access to patient samples and the lack of reliable model systems that truly reflect human cancer biology. The emergence of patient-derived induced pluripotent stem cells and engineered human pluripotent stem cells (hPSCs) has helped overcome these challenges, offering a versatile ...
Huang MF +4 more
europepmc +4 more sources
Cellular reprogramming in skin cancer [PDF]
Seminars in Cancer Biology, 2015 Early primitive stem cells have long been viewed as the cancer cells of origin (tumor initiating target cells) due to their intrinsic features of self-renewal and longevity. However, emerging evidence suggests a surprising capacity for normal committed cells to function as reserve stem cells upon reprogramming as a consequence of tissue damage ...
Song, Ihn Young, Balmain, Allan
openaire +4 more sources
Rationale and Methodology of Reprogramming for Generation of Induced Pluripotent Stem Cells and Induced Neural Progenitor Cells. [PDF]
, 2016 Great progress has been made regarding the capabilities to modify somatic cell fate ever since the technology for generation of induced pluripotent stem cells (iPSCs) was discovered in 2006.
Biswas, Sangita +3 more
core +5 more sources
Cold Spring Harbor Perspectives in Biology, 2014 Nuclear reprogramming technology was first established more than 50 years ago. It can rejuvenate somatic cells by erasing the epigenetic memories and reconstructing a new pluripotent order. The recent discovery reviewed here that induced pluripotency can be achieved by a small set of transcription factors has opened up unprecedented opportunities in ...
openaire +2 more sources
Transcriptional reprogramming in cellular quiescence [PDF]
RNA Biology, 2017 Most cells in nature are not actively dividing, yet are able to return to the cell cycle given the appropriate environmental signals. There is now ample evidence that quiescent G0 cells are not shut-down but still metabolically and transcriptionally active.
Roche, Benjamin +2 more
openaire +2 more sources