Results 11 to 20 of about 1,403,431 (298)
Algorithm for cellular reprogramming [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2017 Significance Reprogramming the human genome toward any desirable state is within reach; application of select transcription factors drives cell types toward different lineages in many settings. We introduce the concept of data-guided control in building a universal algorithm for directly reprogramming any human cell type into any ...
Stephen Lindsly, Lindsey A Muir
exaly +5 more sources
Re: Epigenetics of Cellular Reprogramming
Journal of Urological Surgery, 2016 EDITORIAL COMMENT Cells have some specific molecular and physiological properties that act their functional process. However, many cells have an ability of efficient transition from one type to another. This ability is named plasticity.
Fehmi Narter
doaj +2 more sources
Cellular Reprogramming—A Model for Melanoma Cellular Plasticity [PDF]
International Journal of Molecular Sciences, 2020 Cellular plasticity of cancer cells is often associated with phenotypic heterogeneity and drug resistance and thus remains a major challenge for the treatment of melanoma and other types of cancer. Melanoma cells have the capacity to switch their phenotype during tumor progression, from a proliferative and differentiated phenotype to a more invasive ...
Jochen Utikal +2 more
exaly +3 more sources
Decoding cancer etiology with cellular reprogramming. [PDF]
Curr Opin Genet DevCancer research remains clinically unmet in many areas due to limited access to patient samples and the lack of reliable model systems that truly reflect human cancer biology. The emergence of patient-derived induced pluripotent stem cells and engineered human pluripotent stem cells (hPSCs) has helped overcome these challenges, offering a versatile ...
Huang MF +4 more
europepmc +4 more sources
Cellular reprogramming: Mathematics meets medicine
WIREs Mechanisms of Disease, 2020 AbstractGenerating needed cell types using cellular reprogramming is a promising strategy for restoring tissue function in injury or disease. A common method for reprogramming is addition of one or more transcription factors that confer a new function or identity. Advancements in transcription factor selection and delivery have culminated in successful
Gabrielle A. Dotson +4 more
openaire +5 more sources
Deepening the understanding of CNVs on chromosome 15q11–13 by using hiPSCs: An overview
Frontiers in Cell and Developmental Biology, 2023 The human α7 neuronal nicotinic acetylcholine receptor gene (CHRNA7) is widely expressed in the central and peripheral nervous systems. This receptor is implicated in both brain development and adult neurogenesis thanks to its ability to mediate ...
Angela Maria Giada Giovenale +11 more
doaj +1 more source
Cellular reprogramming and epigenetic rejuvenation [PDF]
Clinical Epigenetics, 2021 AbstractAgeing is an inevitable condition that afflicts all humans. Recent achievements, such as the generation of induced pluripotent stem cells, have delivered preliminary evidence that slowing down and reversing the ageing process might be possible. However, these techniques usually involve complete dedifferentiation, i.e.
Daniel J. Simpson +2 more
openaire +3 more sources
Cellular internalization effect of Ara27 in various cell lines
Journal of Animal Reproduction and Biotechnology, 2022 Protein and peptide candidates are screened to apply therapeutic application as a drug. Ensuring that these candidates are delivered and maximized effectiveness is still challenging and a variety of studies are ongoing.
Minseo Kim +3 more
doaj +1 more source
Cellular Reprogramming by PHF7 Enhances Cardiac Function Following Myocardial Infarction [PDF]
CirculationLin Xu +2 more
exaly +2 more sources
Human Neural Stem Cells for Cell-Based Medicinal Products
Cells, 2021 Neural stem cells represent an attractive tool for the development of regenerative therapies and are being tested in clinical trials for several neurological disorders.
Beatriz Fernandez-Muñoz +3 more
doaj +1 more source