Results 11 to 20 of about 154,639 (265)
Enhanced chromatin accessibility contributes to X chromosome dosage compensation in mammals
Genome Biology, 2021 Background Precise gene dosage of the X chromosomes is critical for normal development and cellular function. In mice, XX female somatic cells show transcriptional X chromosome upregulation of their single active X chromosome, while the other X ...
Irene Talon +13 more
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Molecules, 2021 Salivary gland stem cells (SGSCs) are potential cell sources for the treatment of salivary gland diseases. The control of cell survival is an essential factor for applying stem cells to regenerative medicine or stem cell-based research.
Kichul Kim +4 more
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DNA methylation and cellular reprogramming [PDF]
Trends in Cell Biology, 2010 The recent discovery that a small number of defined factors are sufficient to reprogram somatic cells into pluripotent stem cells has significantly expanded our knowledge of the plasticity of the epigenome. In this review we discuss some aspects of cell fate plasticity and epigenetic alterations, with emphasis on DNA methylation during cellular ...
Daniel D, De Carvalho +2 more
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Molecules, 2020 Human malignant melanoma is the most aggressive type of skin cancer with high metastatic ability. Despite several traditional therapies, the mortality rate remains high. Lactobacillus plantarum (L.
Jaehyun Park +5 more
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Cold Spring Harbor Perspectives in Biology, 2014 Nuclear reprogramming technology was first established more than 50 years ago. It can rejuvenate somatic cells by erasing the epigenetic memories and reconstructing a new pluripotent order. The recent discovery reviewed here that induced pluripotency can be achieved by a small set of transcription factors has opened up unprecedented opportunities in ...
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Stem Cell Research, 2022 Charcot-Marie-Tooth type 4B3 (CMT4B3) is a rare subtype of hereditary neuropathy associated with variants in the MTMR5/SBF1 gene. Herein, we report the generation and characterization of a hiPSC line from a 12-year-old Italian girl with early onset ...
Elisa Maria Turco +12 more
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Journal of Translational Medicine, 2023 Background The incidence of bladder cancer (BCa) is approximately four times higher in men than in women. To develop effective BCa treatments, there is an urgent need to understand the differences in the BCa control mechanisms based on gender. Our recent
Jaekwon Seok +6 more
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Pluripotent Stem Cells for Spinal Cord Injury Repair
Cells, 2021 Spinal cord injury (SCI) is a devastating condition of the central nervous system that strongly reduces the patient’s quality of life and has large financial costs for the healthcare system.
Maria Martin-Lopez +2 more
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Epigenetic impairments in development of parthenogenetic preimplantation mouse embryos
The Journal of Reproduction and Development, 2018 Parthenogenesis is an activation process of oocytes that occur without the participation of sperm. Evidence suggests that normal development of embryos requires proper expression of several imprinted genes inherited from both the paternal and maternal ...
Ngan Thi Kim HO +3 more
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Cellular reprogramming in skin cancer [PDF]
Seminars in Cancer Biology, 2015 Early primitive stem cells have long been viewed as the cancer cells of origin (tumor initiating target cells) due to their intrinsic features of self-renewal and longevity. However, emerging evidence suggests a surprising capacity for normal committed cells to function as reserve stem cells upon reprogramming as a consequence of tissue damage ...
Song, Ihn Young, Balmain, Allan
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