Results 181 to 190 of about 234,206 (306)

Cellular Senescence as a Risk Factor in Head and Neck Cancer-Diagnostic and Therapeutic Perspective. [PDF]

Cancers (Basel)
Stachowiak M, Kostrzewa M, Golusinski W, Golusinski P, Golusinska-Kardach E, Masternak MM, Rubiś B.   +6 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Autophagy, Cellular Senescence and Oxidative Stress in Ageing and Age-Related Diseases. [PDF]

Int J Mol Sci
Trachana V.
europepmc   +1 more source

Changes of genome DNA methylation level during cellular replicative and premature senescence induced by hydrogen peroxide

, 2010
Zhixiong Zhuang
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Cellular senescence in kidney diseases. [PDF]

Chin Med J (Engl)
Wang X, Li Y, Chu Q, Lv H, Li J, Yi F.
europepmc   +1 more source

miR-34 miRNAs Regulate Cellular Senescence in Type II Alveolar Epithelial Cells of Patients with Idiopathic Pulmonary Fibrosis

, 2016
Supparerk Disayabutr, Eun Kyung Kim, Seung Ick, Gary Green, Ram P. Naikawadi, Kirk D. Jones, Jeffrey A. Golden, Aaron Schroeder, Michael A. Matthay, Jasleen Kukreja, David J. Erle, Harold R. Collard, Paul J. Wolters   +12 more
openalex   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The impacts of chronic infections on shaping cellular senescence. [PDF]

Immun Ageing
Johnson A, Rought T, Aronov J, Pokharel P, Chiu A, Nasuhidehnavi A.   +5 more
europepmc   +1 more source