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The Hippo Signaling Pathway Manipulates Cellular Senescence. [PDF]
CellsMiyajima C +9 more
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Cellular senescence in Alzheimer's disease: from physiology to pathology. [PDF]
Transl NeurodegenerZhu J, Wu C, Yang L.
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Current Biology, 2022 Cellular senescence defines a state of stable and generally irreversible proliferative arrest associated with various morphological, structural and functional changes (Figure 1), including enhanced expression and secretion of pro-inflammatory and tissue-remodelling mediators.
Marta Varela-Eirín, M. Demaria
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Cellular Senescence: From Mechanisms to Current Biomarkers and Senotherapies
Pharmacological Reviews, 2023An increase in life expectancy in developed countries has led to a surge of chronic aging-related diseases. In the last few decades, several studies have provided evidence of the prominent role of cellular senescence in many of these pathologies.
Vasco Lucas, C. Cavadas, C. Aveleira
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Journal of Neuro-Oncology, 2023
Glioma is the most common primary brain tumor and is often associated with treatment resistance and poor prognosis. Standard treatment typically involves radiotherapy and temozolomide-based chemotherapy, both of which induce cellular senescence-a tumor suppression mechanism.Gliomas employ various mechanisms to bypass or escape senescence and remain in ...
Rafał, Chojak +3 more
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Glioma is the most common primary brain tumor and is often associated with treatment resistance and poor prognosis. Standard treatment typically involves radiotherapy and temozolomide-based chemotherapy, both of which induce cellular senescence-a tumor suppression mechanism.Gliomas employ various mechanisms to bypass or escape senescence and remain in ...
Rafał, Chojak +3 more
openaire +2 more sources
Cellular senescence and neurodegeneration
Human Genetics, 2023Advancing age is a major risk factor of Alzheimer's disease (AD). The worldwide prevalence of AD is approximately 50 million people, and this number is projected to increase substantially. The molecular mechanisms underlying the aging-associated susceptibility to cognitive impairment in AD are largely unknown.
Kristopher Holloway +3 more
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