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Genetics of cellular senescence
Mechanisms of Ageing and Development, 2002Cellular senescence or replicative senescence is a state of irreversible growth arrest that somatic cells enter as a result of replicative exhaustion. This can be mimicked by culture manipulations such as Ras oncogene overexpression or treatment with various agents such as sodium butyrate and 5-azacytidine.
Olivia M. Pereira-Smith +3 more
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Mechanisms of cellular senescence
Current Opinion in Genetics & Development, 1997Aging is a near universal process, yet the molecular mechanisms that underlie cellular senescence have remained elusive. Recent progress in determining the roles of various genetic influences in controlling the rate of cellular aging has made this an exciting time in aging research.
Leonard Guarente, Tod Smeal
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Cellular senescence in the cholangiopathies
Current Opinion in Gastroenterology, 2021Purpose of review Cellular senescence (i.e. permanent withdrawal from the cell cycle) is increasingly recognized as a pathologic feature in a variety of inflammatory liver diseases, including primary sclerosing cholangitis (PSC), primary biliary cholangitis (PBC) and additional cholangiopathies.
Pamela S, Bogert +2 more
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Current Opinion in Cell Biology, 1991
Differentiated eukaryotic cells have only a finite capacity for cell division. This limitation is thought to be a cellular manifestation of organismal aging, and a restraint to tumor progression. The molecular basis for cellular senescence is not known, but a molecular framework for understanding this phenomenon has recently been established.
Judith Campisi, Anna M. McCormick
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Differentiated eukaryotic cells have only a finite capacity for cell division. This limitation is thought to be a cellular manifestation of organismal aging, and a restraint to tumor progression. The molecular basis for cellular senescence is not known, but a molecular framework for understanding this phenomenon has recently been established.
Judith Campisi, Anna M. McCormick
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Hypertension and cellular senescence
Biogerontology, 2023Essential or primary hypertension is a wordwide health problem. Elevated blood pressure (BP) is closely associated not only with increased chronological aging but also with biological aging. There are various common pathways that play a role in cellular aging and BP regulation.
Baris, Afsar, Rengin Elsurer, Afsar
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2015
The term senescence was coined more than 50 years ago to describe the loss of replicative capacity of normal human diploid cells in culture.1 At that time, senescence was proposed to generally reflect the process of cellular aging.2., 3. Early studies also noted differences between the propensity of normal and malignant cells to senesce, with malignant
Bolden, Jessica E., Lowe, Scott W.
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The term senescence was coined more than 50 years ago to describe the loss of replicative capacity of normal human diploid cells in culture.1 At that time, senescence was proposed to generally reflect the process of cellular aging.2., 3. Early studies also noted differences between the propensity of normal and malignant cells to senesce, with malignant
Bolden, Jessica E., Lowe, Scott W.
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Annals of the Rheumatic Diseases, 2021
Objective The aim of the study was to investigate the role and regulatory mechanisms of fibroblast-like synoviocytes (FLSs) and their senescence in the progression of osteoarthritis (OA). Methods Synovial tissues from normal patients and patients with OA
Xiang Chen +10 more
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Objective The aim of the study was to investigate the role and regulatory mechanisms of fibroblast-like synoviocytes (FLSs) and their senescence in the progression of osteoarthritis (OA). Methods Synovial tissues from normal patients and patients with OA
Xiang Chen +10 more
semanticscholar +1 more source
Phosphate and Cellular Senescence
2022Cellular senescence is one type of permeant arrest of cell growth and one of increasingly recognized contributor to aging and age-associated disease. High phosphate and low Klotho individually and synergistically lead to age-related degeneration in multiple organs.
Ming Chang, Hu, Orson W, Moe
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Cellular Senescence and Ageing
2023Cellular senescence has become a subject of great interest within the ageing research field over the last 60 years, from the first observation in vitro by Leonard Hayflick and Paul Moorhead in 1961, to novel findings of phenotypic sub-types and senescence-like phenotype in post-mitotic cells.
Reed R, Miwa S
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Cellular senescence and atherosclerosis
Medical Hypotheses, 1984Most recent texts on atherosclerosis do not consider cellular senescence. Texts that do take this up often emphasize smooth muscle cells. This paper presents some evidence for the role of cellular senescence in atherogenesis, and points out that the cells of the intimal endothelium may be equally important in this respect.
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