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Markers of Cellular Senescence
2012Cellular senescence is a tumor suppression mechanism that evolved to limit duplication in somatic cells. Senescence is imposed by natural replicative boundaries or stress-induced signals, such as oncogenic transformation. Neoplastic cells can be forced to undergo senescence through genetic manipulations and epigenetic factors, including anticancer ...
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Cellular senescence: when bad things happen to good cells
Nature reviews. Molecular cell biology, 2007J. Campisi, F. D. D. Fagagna
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Cellular Senescence and Senescent Cell*
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2012Jian-Hong Zhu +5 more
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Cellular senescence and PAPP-A
Growth Hormone & IGF ResearchCellular senescence and its accompanying secretome have major impact on growth and aging of mammalian organisms. A novel protease, PAPP-A, regulates the bioavailability of an important growth factor, insulin-like growth factor (IGF)-I, and has major impact on growth and aging.
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Cellular senescence: from physiology to pathology
Nature reviews. Molecular cell biology, 2014D. Muñoz-Espín, M. Serrano
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microRNA in cellular senescence
2010Senescence is recognized as a permanent arrest of cell proliferation triggered by telomere shortening or various stresses. Senescence imposes a barrier to tumorigenesis and contributes to aging. It represents a cell response that encompasses gene expression regulation at transcriptional and post-transcriptional levels.
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The role of cellular senescence in cardiac disease: basic biology and clinical relevance
Nature Reviews Cardiology, 2021Mozhdeh Mehdizadeh +4 more
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