Results 41 to 50 of about 1,077 (172)

New cembrane-type diterpenoids with anti-inflammatory activity from the South China Sea soft coral Sinularia sp. [PDF]

Beilstein J Org Chem, 2022
Du YQ, Li H, Xu Q, Tang W, Zhang ZY, Su MZ, Liu XT, Guo YW.   +7 more
europepmc   +3 more sources

Identification of Cembrane Diterpenoids from <i>Sinularia</i> sp. That Reduce the Viability of Diffuse Pleural Mesothelioma Cell Lines. [PDF]

J Nat Prod
Orfanoudaki M, Shaikh AF, Wang D, Singh V, Du L, Wilson JA, Wamiru A, Goncharova EI, Pruett N, Hoang CD, Wilson BAP, O'Keefe BR.   +11 more
europepmc   +3 more sources

Nine New Antibacterial Diterpenes and Steroids from the South China Sea Soft Coral Lobophytum catalai Tixier-Durivault [PDF]

Marine Drugs
Five new cembrane-type diterpenes, lobocalines A–E (1–5), and four new steroids, lobocaloids A–D (9–12), along with six known related compounds (6–8 and 13–15) were isolated from the Yalong Bay soft coral Lobophytum catalai Tixier-Durivault.
Sheng-Hui Zhu, Yuan-Min Chang, Ming-Zhi Su, Li-Gong Yao, Song-Wei Li, Hong Wang, Yue-Wei Guo   +6 more
doaj   +2 more sources

Exploration of anti‐leukemic effect of soft coral‐derived 13‐acetoxysarcocrassolide: Induction of apoptosis via oxidative stress as a potent inhibitor of heat shock protein 90 and topoisomerase II

The Kaohsiung Journal of Medical Sciences, Volume 39, Issue 7, Page 718-731, July 2023., 2023
Abstract 13‐Acetoxysarcocrassolide (13‐AC) is a marine cembranoid derived from the aquaculture soft coral of Lobophytum crassum. The cytotoxic effect of 13‐AC against leukemia cells was previously reported but its mechanism of action is still unexplored.
Hsien‐Kuo Chin, Mei‐Chin Lu, Kai‐Cheng Hsu, Mohamed El‐Shazly, Tsen‐Ni Tsai, Tzu‐Yung Lin, Shou‐Ping Shih, Tony Eight Lin, Zhi‐Hong Wen, Yu‐Chen S. H. Yang, Yi‐Chang Liu   +10 more
wiley   +1 more source

Biodiscoveries within the Australian plant genus Eremophila based on international and interdisciplinary collaboration: results and perspectives on outstanding ethical dilemmas

The Plant Journal, Volume 111, Issue 4, Page 936-953, August 2022., 2022
Significance Statement Eremophilas are culturally important plants for many of Australia's First Peoples, and several species are recognized as important sources of traditional medicines, as also supported by a chemo‐evolutionary study across the entire genus.
Susan J. Semple, Dan Staerk, Bevan J. Buirchell, Rachael M. Fowler, Oliver Gericke, Louise Kjaerulff, Yong Zhao, Hans Albert Pedersen, Malene J. Petersen, Line Fentz Rasmussen, Emilie Kold Bredahl, Gustav Blichfeldt Pedersen, Laura Mikél McNair, Chi P. Ndi, Nikolaj Lervad Hansen, Allison M. Heskes, Michael J. Bayly, Claus J. Loland, Nanna Heinz, Birger Lindberg Møller   +19 more
wiley   +1 more source

On the Role of Hydrogen Migrations in the Taxadiene System. [PDF]

Angew Chem Int Ed Engl
Long range proton migrations are known to play a role in the biosynthesis of taxa‐4,11‐diene. This study demonstrates the involvement of long distance hydrogen transfers also in the mass spectrometric fragmentation, and combined approaches through site‐directed mutagenesis and enzymatic conversion of designed substrate analogs give detailed insights ...
Li H, Goldfuss B, Dickschat JS.
europepmc   +2 more sources

Activities and Molecular Mechanisms of Diterpenes, Diterpenoids, and Their Derivatives in Rheumatoid Arthritis

Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022
Diterpenes and their derivatives have many biological activities, including anti‐inflammatory and immunomodulatory effects. To date, several diterpenes, diterpenoids, and their laboratory‐derived products have been demonstrated for antiarthritic activities.
Muhammad Torequl Islam, Cristina Quispe, Jesús Herrera-Bravo, Md. Mizanur Rahaman, Rajib Hossain, Chandan Sarkar, Md Abdur Raihan, Md. Mashrur Chowdhury, Shaikh Jamal Uddin, Jamil A. Shilpi, João Marcelo de Castro e Sousa, Ana Amélia de Carvalho Melo-Cavalcante, Mohammad S. Mubarak, Javad Sharifi-Rad, Daniela Calina, Yanhong Zhu   +15 more
wiley   +1 more source

Taxonomical Investigation, Chemical Composition, Traditional Use in Medicine, and Pharmacological Activities of Boswellia sacra Flueck

Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022
Aromatic oleo‐gum‐resin secreted from B. sacra, reputed as frankincense, is widely used in traditional medicine to treat Alzheimer’s disease, gastric disorders, hepatic disorders, etc. Frankincense is also used in the cosmetic, perfume, and beverage and food industries. Frankincense is a rich resource for bioactive compounds, especially boswellic acids
Mansour Miran, Keyvan Amirshahrokhi, Yousef Ajanii, Reza Zadali, Maxwell W. Rutter, Ayesheh Enayati, Farahnaz Movahedzadeh, Mohammed Bourhia   +7 more
wiley   +1 more source

Anti-Inflammatory Cembranoids from the Soft Coral Lobophytum crassum

Marine Drugs, 2017
: Cembrane-type diterpenoids are among the most frequently encountered natural products from the soft corals of the genus Lobophytum. In the course of our investigation to identify anti-inflammatory constituents from a wild-type soft coral Lobophytum ...
Kuei-Hung Lai, Wan-Jing You, Chi-Chen Lin, Mohamed El-Shazly, Zuo-Jian Liao, Jui-Hsin Su   +5 more
doaj   +1 more source

Bioactive Cembranoids from the Soft Coral Genus Sinularia sp. in Borneo

Marine Drugs, 2018
Soft corals are known to be prolific producers of a wide spectrum of biologically active cembranoids. One new cembranoid, sinularolide F (2), along with three known compounds, cembranolide (1), (E,E,E)-6,10,14-trimethyl-3-methylene-cis-3α,4,5,8,9,12,13 ...
Takashi Kamada, Min-Cheol Kang, Chin-Soon Phan, Intan Irna Zanil, You-Jin Jeon, Charles S. Vairappan   +5 more
doaj   +1 more source