Results 31 to 40 of about 873 (161)

The biosynthesis of the anti‐microbial diterpenoid leubethanol in Leucophyllum frutescens proceeds via an all‐cis prenyl intermediate

open access: yesThe Plant Journal, Volume 104, Issue 3, Page 693-705, November 2020., 2020
SUMMARY Serrulatane diterpenoids are natural products found in plants from a subset of genera within the figwort family (Scrophulariaceae). Many of these compounds have been characterized as having anti‐microbial properties and share a common diterpene backbone.
Garret P. Miller   +5 more
wiley   +1 more source

An Unexpected Transannular [4+2] Cycloaddition during the Total Synthesis of (+)‐Norcembrene 5

open access: yesAngewandte Chemie International Edition, Volume 59, Issue 14, Page 5521-5525, March 27, 2020., 2020
They may look alike… During studies toward the total synthesis of the norditerpene natural product norcembrene 5, one diastereomer of a key intermediate (α‐OAc at C13) underwent clean and spontaneous Diels–Alder cycloaddition at room temperature (see scheme).
Michael Breunig, Po Yuan, Tanja Gaich
wiley   +1 more source

Natural Cembrane Diterpenoids From the Soft Coral

open access: yesNatural Product Communications, 2021
Chemical examination of Sinularia querciformis afforded one new cembranoid, querciformolide F ( 1 ), along with four known cembranoids, sinulariolone ( 2 ), granosolide A ( 3 ), querciformolide A ( 4 ), and sinulariolide ( 5 ).
Yi-Ying Wu   +7 more
doaj   +1 more source

Polyoxygenated Cembrane Diterpenoids from the Soft Coral Sarcophyton ehrenbergi [PDF]

open access: yesInternational Journal of Molecular Sciences, 2015
Five new polyoxygenated cembranoids, named (+)-1,15-epoxy-2-methoxy-12-methoxycarbonyl-11E-sarcophytoxide (1), (+)-2-epi-12-methoxycarbonyl-11E-sarcophine (2), 3,4-epoxyehrenberoxide A (3), ehrenbergol D (4) and ehrenbergol E (5), were obtained from the soft coral Sarcophyton ehrenbergi.
Cheng, Shi-Yie   +3 more
openaire   +2 more sources

EBC‐342: A Novel Tetrahydrofuran Moiety Containing Casbane from the Australian Rainforest

open access: yesEuropean Journal of Organic Chemistry, Volume 2020, Issue 8, Page 1042-1045, February 28, 2020., 2020
Although well known, the casbane family of natural products are not often isolated from either terrestrial or marine environments. The Australian Rainforest plant Croton insularis has provided a number of interesting casbanes, of which EBC‐342 described herein, is the first to contain a tetrahydrofuran ring.
Lidia A. Maslovskaya   +9 more
wiley   +1 more source

A High-Content Screening Assay for the Discovery of Novel Proteasome Inhibitors from Formosan Soft Corals

open access: yesMarine Drugs, 2018
The ubiquitin-proteasome system (UPS) is a major proteolytic pathway that safeguards protein homeostasis. The main 26S proteasome consists of a 20S catalytic core proteasome and a 19S substrate recognition proteasome.
Xue-Hua Ling   +4 more
doaj   +1 more source

Terpenoids from the Octocorals Menella sp. (Plexauridae) and Lobophytum crassum (Alcyonacea)

open access: yesMarine Drugs, 2012
A new germacrane-type sesquiterpenoid, menelloide E (1), and a new cembrane-type diterpenoid, lobocrassin F (2), were isolated from the octocorals Menella sp. and Lobophytum crassum, respectively.
Zhi-Hong Wen   +8 more
doaj   +1 more source

A macrolactonisation approach to the cembrane carbocycle of bielschowskysin

open access: yesTetrahedron Letters, 2013
By judicious choice of a conformationally constraining unit to predispose cyclisation to a 15-membered ring, we present a straightforward strategy to a cembranolide precursor of bielschowskysin by the Sonogashira coupling of two readily prepared fragments (from D-glucose and L-malic acid) followed by a facile beta-acylketene macrolactonisation reaction.
Yang, E.G., Sekar, K., Lear, M.J.
openaire   +2 more sources

New Anti-Inflammatory Cembranes from the Cultured Soft Coral Nephthea columnaris

open access: yesMarine Drugs, 2015
Two new cembranes, columnariols A (1) and B (2), were isolated from the cultured soft coral Nephthea columnaris. The structures of cembranes 1 and 2 were elucidated by spectroscopic methods.
Ting-Hsi Hsiao   +7 more
doaj   +1 more source

Cembrane diterpenes as chemotaxonomical markers for Sinularia flexibilis

open access: yesJournal of Tropical Biology & Conservation (JTBC), 2023
Chemical extraction of the soft coral Sinularia flexibilis collected from Mantanani Island, Kota Belud, Sabah has led to the isolation of ten known cembrane diterpenes. The chemical structures of isolated compounds were elucidated based on 1H-NMR and 13C-NMR spectroscopic data. This is the first record of chemical analysis of S.
Kishneth Palaniveloo   +2 more
openaire   +1 more source

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