Results 41 to 50 of about 2,095 (251)

New pyranosyl cembranoid diterpenes from Sarcophyton trocheliophorum [PDF]

Natural Product Research, 2018
During our continual searching programme for novel bioactive metabolites from Sarcophyton trocheliophorum, collected from Red Sea, we describe herein the isolation and structural elucidation of further two new pyrane-based cembranoid diterpenes: 9-hydroxy-7,8-dehydro-sarcotrocheliol (1) and 8,9-expoy-sarcotrocheliol acetate (2), along with the well ...
Mohamed Shaaban, Marwa Y. Issa, Mohamed A. Ghani, Abdelaaty Hamed, Ahmed B. Abdelwahab   +4 more
openalex   +5 more sources

Pharmacokinetics and Metabolism of 4R-Cembranoid

PLOS ONE, 2015
4R-cembranoid (4R) is a natural cyclic diterpenoid found in tobacco leaves that displays neuroprotective activity. 4R protects against NMDA, paraoxon (POX), and diisopropylfluorophosphate (DFP) damage in rat hippocampal slices and against DFP in rats in vivo.
Wanda Velez‐Carrasco, Carol E. Green, Paul Catz, Anna Furimsky, Kathleen O’Loughlin, Vesna A. Eterović, P.A. Ferchmin   +6 more
openalex   +6 more sources

On-Line Analysis of Cigarette Smoke Based on Microwave Plasma Torch Mass Spectrometry. [PDF]

ChemistryOpen
Cigarette smoke contains a large number of flavor components and harmful substances, so it is crucial to establish an effective method for smoke detection and analysis. This article provides a method for on‐line analysis of smoke with MPT‐MS (Microwave plasma torch mass spectrometry), and achieved detection of 22 flavor compounds and 2 polycyclic ...
Tang H, Yuan K, Chu F, Zhang X, Li Q, Chen Q, Feng H, Pan Y.   +7 more
europepmc   +2 more sources

Tobacco Cembranoids [PDF]

Beiträge zur Tabakforschung / Contributions to Tobacco Research, 1984
AbstractThe discovery of the first diterpenoids of the cembrane type in tobacco dates back to the early 1960's. Since then some forty tobacco cembranoids have been encountered. Most of these have a hydroxyl substituent at C-4 and are commonly divided into two series: those having a 4R- and those having a 4S-configuration.
I. Wahlberg, C. R. Enzell
openaire   +1 more source

Conformational study of the cembranoid sarcophytol A, a potent anti-tumor-promoter.

Chemical and Pharmaceutical Bulletin, 1990
Conformational analysis of the marine cembranoid sarcophytol A (1a), a potent anti-tumor promoter, was carried out using a newly introduced molecular mechanic and molecular dynamic program Discover. Four minimum-energy conformations were derived, in accordance with a previous results of the epoxidation of 1a, which afforded 7R,8R/7S,8S- and 11R,12R/11S,
M Kobayashi, Kazuo Kobayashi, Mitsushiro Nomura, Hiroshi Munakata   +3 more
openalex   +5 more sources

Synthesis and Evaluation of a 2,11‐Cembranoid‐Inspired Library [PDF]

Chemistry – A European Journal, 2016
AbstractThe 2,11‐cembranoid family of natural products has been used as inspiration for the synthesis of a structurally simplified, functionally diverse library of octahydroisobenzofuran‐based compounds designed to augment a typical medicinal chemistry library screen. Ring‐closing metathesis, lactonisation and SmI2‐mediated methods were exemplified and
Amanda J Welford, John Caldwell, Manjuan Liu, Meirion Richards, Nathan Brown, C. Lomas, Graham J. Tizzard, Mateusz B. Pitak, Simon J. Coles, Suzanne A. Eccles, Florence I. Raynaud, Ian Collins   +11 more
openalex   +5 more sources

Methyl jasmonate‐dependent hydrogen sulfide mediates melatonin‐induced aphid resistance of watermelon

Food and Energy Security, Volume 12, Issue 5, September 2023., 2023
Abstract As one of the most destructive pests, aphids cause significant damage on various agricultural and horticultural crops. Recently, melatonin has been shown to enhance plant resistance to aphids; however, the underlying mechanisms remain unclear.
Zhuangzhuang Su, Zhixiang Lan, Yufan Gao, Yunfei Liu, Jian Shen, Yanliang Guo, Jianxiang Ma, Yong Zhang, Feishi Luan, Xian Zhang, Hao Li   +10 more
wiley   +1 more source

Exploration of anti‐leukemic effect of soft coral‐derived 13‐acetoxysarcocrassolide: Induction of apoptosis via oxidative stress as a potent inhibitor of heat shock protein 90 and topoisomerase II

The Kaohsiung Journal of Medical Sciences, Volume 39, Issue 7, Page 718-731, July 2023., 2023
Abstract 13‐Acetoxysarcocrassolide (13‐AC) is a marine cembranoid derived from the aquaculture soft coral of Lobophytum crassum. The cytotoxic effect of 13‐AC against leukemia cells was previously reported but its mechanism of action is still unexplored.
Hsien‐Kuo Chin, Mei‐Chin Lu, Kai‐Cheng Hsu, Mohamed El‐Shazly, Tsen‐Ni Tsai, Tzu‐Yung Lin, Shou‐Ping Shih, Tony Eight Lin, Zhi‐Hong Wen, Yu‐Chen S. H. Yang, Yi‐Chang Liu   +10 more
wiley   +1 more source

New Eunicellin-Type Diterpenes from the Panamanian Octocoral Briareum Asbestinum [PDF]

, 2020
Gorgonian octocorals are considered a prolific source of secondary metabolites with a wide range of biological activities, including anti-inflammatory activity.
Elena Talero, Héctor M. Guzmán, Javier Ávila-Román, José Félix Gómez-Reyes, Marcelino Gutiérrez, Ricardo Santamaría, Virginia Motilva   +6 more
core   +1 more source

A Vicinal Diol Approach for the Total Synthesis of Molestin E, ent‐Sinulacembranolide A and ent‐Sinumaximol A

Chemistry – A European Journal, Volume 28, Issue 63, November 11, 2022., 2022
The convergent total synthesis of furanocembranoids (FC) molestin E, ent‐sinulacembranolide A and ent‐sinumaximol A was achieved in 20–21 steps in the longest linear sequence (LLS). Building blocks were coupled through a furan metalation sequence and macrocycle formation was effected by Shiina lactonisation. The primary target molestin E was elaborated
Oskar Hoff, Nicolas Kratena, Daniya Aynetdinova, Kirsten E. Christensen, Timothy J. Donohoe   +4 more
wiley   +1 more source