Results 51 to 60 of about 708 (179)

Pharmacokinetics and Metabolism of 4R-Cembranoid

PLOS ONE, 2015
4R-cembranoid (4R) is a natural cyclic diterpenoid found in tobacco leaves that displays neuroprotective activity. 4R protects against NMDA, paraoxon (POX), and diisopropylfluorophosphate (DFP) damage in rat hippocampal slices and against DFP in rats in vivo.
Wanda Vélez-Carrasco, Carol E Green, Paul Catz, Anna Furimsky, Kathleen O'Loughlin, Vesna A Eterović, P A Ferchmin   +6 more
openaire   +4 more sources

Enzymkatalysierte späte Modifizierungen: Besser spät als nie

Angewandte Chemie, Volume 133, Issue 31, Page 16962-16993, July 26, 2021., 2021
Späte Modifizierungen sind unerlässlich für die Diversifizierung von Verbindungen in der Synthese. Da Enzyme effiziente Werkzeuge für milde, Katalysator‐kontrollierte Funktionalisierungen bieten, sind neue biokatalytische Methoden für eine große Fülle orthogonaler Reaktionen entstanden.
Elvira Romero, Bethan S. Jones, Bethany N. Hogg, Arnau Rué Casamajo, Martin A. Hayes, Sabine L. Flitsch, Nicholas J. Turner, Christian Schnepel   +7 more
wiley   +1 more source

Cembranoids from the cultured soft coral <i>Sinularia sandensis</i>. [PDF]

RSC Adv
This study reports the isolation and characterization of two novel diterpenoids, norcembranoid 10- epi -dehydrogyrosanolide E (1) and cembranoid 8- epi -flexibilisolide G (2), from the cultured soft coral Sinularia sandensis
Lai KH, Liang CY, Chen YY, Liao TW, Chen LY, Peng BR, Su JH, El-Shazly M.   +7 more
europepmc   +3 more sources

Bioactive Natural, Biocatalytic, and Semisynthetic Tobacco Cembranoids

Planta Medica, 2010
The two major Nicotiana tabacum tobacco cembranoids, (1 S,2 E,4 R,6 R,7 E,11 E)-2,7,11-cembratriene-4,6-diol (1) and its C-4 epimer, exhibit a wide range of interesting biological activities. Although the tumorigenesis inhibition activity of tobacco cembranoids have been known since the mid 1980's, only a limited number of investigations have targeted ...
Hany N, Baraka, Mohammad A, Khanfar, John C, Williams, Emad M, El-Giar, Khalid A, El Sayed   +4 more
  +6 more sources

An Improved Synthesis of 7, 8-Epoxy-1,3,11-cembratriene-15R(α), 16-diol, a Cembranoid of Marine Origin with a Potent Cancer Chemopreventive Activity

Marine Drugs, 2004
An effective method for the synthesis of 7,8-epoxy-1,3,11-cembratriene-15R(α), 16-diol and its in vitro Epstein-Barr Virus Early Antigen (EBV-EA) Activation Chemopreventive Assay are reported.
Sherief I. Khalifa, Hesham Fahmy, Jordan K. Zjawiony, Takao Konoshima   +3 more
doaj   +1 more source

New Antiproliferative Cembrane Diterpenes from the Red Sea Sarcophyton Species

Marine Drugs, 2019
The combination of liquid chromatography coupled to high resolution mass spectrometry (LC-HRESMS)-based dereplication and antiproliferative activity-guided fractionation was applied on the Red Sea-derived soft coral Sarcophyton sp.
Hossam M. Hassan, Mostafa E. Rateb, Marwa H. Hassan, Ahmed M. Sayed, Samah Shabana, Mai Raslan, Elham Amin, Fathy A. Behery, Osama M. Ahmed, Abdullatif Bin Muhsinah, Tobias A. M. Gulder, Usama Ramadan Abdelmohsen   +11 more
doaj   +1 more source

Tobacco Cembranoids Block Behavioral Sensitization To Nicotine And Inhibit Neuronal Acetylcholine Receptor Function [PDF]

, 2001
Cembranoids are cyclic diterpenoids found in tobacco and in marine invertebrates. The present study established that tobacco cembranoids inhibit behavioral sensitization to nicotine in rats and block several types of nicotine acetylcholine receptors ...
Lukas, R. J., Pagn, O. R., Rosado, M., Nicolau, Y., Cortés, S., Fryer, J. D., Ferchmin, P. A., Rodríguez, A. D., Eterovi, V. A., Hann, R. M., Eaton, J. B.   +10 more
core   +1 more source

New Terpenes from the Egyptian Soft Coral Sarcophyton ehrenbergi

Marine Drugs, 2014
Chemical investigations of the Egyptian soft coral Sarcophyton ehrenbergi have led to the isolation of compounds 1–3 as well as the previously reported marine cembranoid diterpene sarcophine (4).
Ahmed Elkhateeb, Ahmed A. El-Beih, Amira M. Gamal-Eldeen, Montaser A. Alhammady, Shinji Ohta, Paul W. Paré, Mohamed-Elamir F. Hegazy   +6 more
doaj   +1 more source

Total Synthesis of the Marine Diterpenoids Caucanolide E and F by Alkyne gem‐Hydrogenation: Rigorous Reassignment of Two Almost Indistinguishable Diastereomers

Angewandte Chemie, Volume 137, Issue 18, April 25, 2025.
The application of gem‐hydrogenation, which exploits the electrophilic character of the ruthenium carbene intermediates transiently formed, to natural product total synthesis allowed the stereostructure of a pair of diastereomeric seco‐cembranoids that are almost indistinguishable by NMR to be rigorously assigned.
Ricardo Molina Betancourt, Markus Leutzsch, Alois Fürstner   +2 more
wiley   +2 more sources

Cytotoxic Effects of Sarcophyton sp. Soft Corals—Is There a Correlation to Their NMR Fingerprints?

Marine Drugs, 2017
Sarcophyton sp. soft corals are rich in cembranoid diterpenes, which represent the main chemical defense of corals against their natural predators in addition to their myriad biological effects in humans. Quantitative NMR (qNMR) was applied for assessing
Mohamed A. Farag, Mostafa I. Fekry, Montasser A. Al-Hammady, Mohamed N. Khalil, Hesham R. El-Seedi, Achim Meyer, Andrea Porzel, Hildegard Westphal, Ludger A. Wessjohann   +8 more
doaj   +1 more source