Results 41 to 50 of about 708 (179)

Cembranoids of Soft Corals: Recent Updates and Their Biological Activities. [PDF]

Nat Prod Bioprospect, 2021
Abstract Soft corals are well-known as excellent sources of marine-derived natural products. Among them, members of the genera Sarcophyton, Sinularia, and Lobophytum are especially attractive targets for marine natural product research.
Nurrachma MY, Sakaraga D, Nugraha AY, Rahmawati SI, Bayu A, Sukmarini L, Atikana A, Prasetyoputri A, Izzati F, Warsito MF, Putra MY.   +10 more
europepmc   +6 more sources

Effect of guggulsterone and cembranoids of Commiphora mukul on pancreatic phospholipase A2: Role in hypocholesterolemia [PDF]

, 2009
Guggulsterone (7) and cembranoids (8-12) from Commiphora mukul stem bark resin guggul were shown to be specific modulators of two independent sites that are also modulated by bile salts (1-6) to control cholesterol absorption and catabolism ...
Tatulian, Suren A., Bai, Shi, Berg, Otto G., Jain, Mahendra K., El Sayed, Khalid A., Kaimal, Rajani, Apitz, Rafael J., Yu, Bao Zhu, Deng, Ruitang   +8 more
core   +5 more sources

Exploration of anti‐leukemic effect of soft coral‐derived 13‐acetoxysarcocrassolide: Induction of apoptosis via oxidative stress as a potent inhibitor of heat shock protein 90 and topoisomerase II

The Kaohsiung Journal of Medical Sciences, Volume 39, Issue 7, Page 718-731, July 2023., 2023
Abstract 13‐Acetoxysarcocrassolide (13‐AC) is a marine cembranoid derived from the aquaculture soft coral of Lobophytum crassum. The cytotoxic effect of 13‐AC against leukemia cells was previously reported but its mechanism of action is still unexplored.
Hsien‐Kuo Chin, Mei‐Chin Lu, Kai‐Cheng Hsu, Mohamed El‐Shazly, Tsen‐Ni Tsai, Tzu‐Yung Lin, Shou‐Ping Shih, Tony Eight Lin, Zhi‐Hong Wen, Yu‐Chen S. H. Yang, Yi‐Chang Liu   +10 more
wiley   +1 more source

A Vicinal Diol Approach for the Total Synthesis of Molestin E, ent‐Sinulacembranolide A and ent‐Sinumaximol A

Chemistry – A European Journal, Volume 28, Issue 63, November 11, 2022., 2022
The convergent total synthesis of furanocembranoids (FC) molestin E, ent‐sinulacembranolide A and ent‐sinumaximol A was achieved in 20–21 steps in the longest linear sequence (LLS). Building blocks were coupled through a furan metalation sequence and macrocycle formation was effected by Shiina lactonisation. The primary target molestin E was elaborated
Oskar Hoff, Nicolas Kratena, Daniya Aynetdinova, Kirsten E. Christensen, Timothy J. Donohoe   +4 more
wiley   +1 more source

Cembrene Diterpenoids with Ether Linkages from Sarcophyton ehrenbergi: An Anti-Proliferation and Molecular-Docking Assessment

Marine Drugs, 2017
Three new cembrene diterpenoids, sarcoehrenbergilid A–C (1–3), along with four known diterpenoids, sarcophine (4), (+)-7α,8β-dihydroxydeepoxysarcophine (5), sinulolide A (6), and sinulolide B (7), and one steroid, sardisterol (8), were isolated and ...
Mohamed-Elamir F. Hegazy, Abdelsamed I. Elshamy, Tarik A. Mohamed, Ahmed R. Hamed, Mahmoud A. A. Ibrahim, Shinji Ohta, Paul W. Paré   +6 more
doaj   +1 more source

Oxygenating Biocatalysts for Hydroxyl Functionalisation in Drug Discovery and Development

ChemMedChem, Volume 17, Issue 12, June 20, 2022., 2022
C−H bond oxyfunctionalisation is a significant challenge in organic synthetic chemistry. In drug discovery and development, exploiting biocatalytic methods which can introduce hydroxyl groups deftly with high selectivity, under mild conditions, is of paramount interest.
Sacha N. Charlton, Martin A. Hayes
wiley   +1 more source

Synthesis and Evaluation of a 2,11‐Cembranoid‐Inspired Library [PDF]

Chemistry – A European Journal, 2016
AbstractThe 2,11‐cembranoid family of natural products has been used as inspiration for the synthesis of a structurally simplified, functionally diverse library of octahydroisobenzofuran‐based compounds designed to augment a typical medicinal chemistry library screen. Ring‐closing metathesis, lactonisation and SmI2‐mediated methods were exemplified and
Welford, AJ, Caldwell, JJ, Liu, M, Richards, M, Brown, N, Lomas, C, Tizzard, GJ, Pitak, MB, Coles, SJ, Eccles, SA, Raynaud, FI, Collins, I   +11 more
openaire   +3 more sources

The chemotype core collection of genus Nicotiana

The Plant Journal, Volume 110, Issue 5, Page 1516-1528, June 2022., 2022
SUMMARY Sustainable production of chemicals and improving these biosources by engineering metabolic pathways to create efficient plant‐based biofactories relies on the knowledge of available chemical/biosynthetic diversity present in the plant. Nicotiana species are well known for their amenability towards transformation and other new plant breeding ...
Margit Drapal, Eugenia M. A. Enfissi, Paul D. Fraser   +2 more
wiley   +1 more source

New Cembrane-Type Diterpenoids from the South China Sea Soft Coral Sarcophyton ehrenbergi

Molecules, 2016
Chemical investigation on the soft coral Sarcophyton ehrenbergi collected from the Xisha Islands of the South China Sea have led to the isolation of eight cembranoids including five new ones, sarcophytonoxides A–E (1–5). The structures of new cembranoids
Gui-Hua Tang, Zhang-Hua Sun, Yi-Hong Zou, Sheng Yin   +3 more
doaj   +1 more source

Phylogeny, Phytomedicines, Phytochemistry, Pharmacological Properties, and Toxicity of Croton gratissimus Burch (Euphorbiaceae)

Advances in Pharmacological and Pharmaceutical Sciences, Volume 2022, Issue 1, 2022., 2022
Croton gratissimus is an important plant in Africa setup and across the globe for its ethnomedicinal uses in managing a wide range of diseases. Its phylogeny, pharmacological properties, ethnomedicinal uses, phytochemistry, and cytotoxicity have been highlighted in various articles and journals.
Kirkland Dingili Magwilu, Joseph Mwanzia Nguta, Isaac Mapenay, Dorine Matara, Srinivas Mutalik   +4 more
wiley   +1 more source