Results 51 to 60 of about 2,095 (251)

Oxygenating Biocatalysts for Hydroxyl Functionalisation in Drug Discovery and Development

ChemMedChem, Volume 17, Issue 12, June 20, 2022., 2022
C−H bond oxyfunctionalisation is a significant challenge in organic synthetic chemistry. In drug discovery and development, exploiting biocatalytic methods which can introduce hydroxyl groups deftly with high selectivity, under mild conditions, is of paramount interest.
Sacha N. Charlton, Martin A. Hayes
wiley   +1 more source

The chemotype core collection of genus Nicotiana

The Plant Journal, Volume 110, Issue 5, Page 1516-1528, June 2022., 2022
SUMMARY Sustainable production of chemicals and improving these biosources by engineering metabolic pathways to create efficient plant‐based biofactories relies on the knowledge of available chemical/biosynthetic diversity present in the plant. Nicotiana species are well known for their amenability towards transformation and other new plant breeding ...
Margit Drapal, Eugenia M. A. Enfissi, Paul D. Fraser   +2 more
wiley   +1 more source

Phylogeny, Phytomedicines, Phytochemistry, Pharmacological Properties, and Toxicity of Croton gratissimus Burch (Euphorbiaceae)

Advances in Pharmacological and Pharmaceutical Sciences, Volume 2022, Issue 1, 2022., 2022
Croton gratissimus is an important plant in Africa setup and across the globe for its ethnomedicinal uses in managing a wide range of diseases. Its phylogeny, pharmacological properties, ethnomedicinal uses, phytochemistry, and cytotoxicity have been highlighted in various articles and journals.
Kirkland Dingili Magwilu, Joseph Mwanzia Nguta, Isaac Mapenay, Dorine Matara, Srinivas Mutalik   +4 more
wiley   +1 more source

Enzymkatalysierte späte Modifizierungen: Besser spät als nie

Angewandte Chemie, Volume 133, Issue 31, Page 16962-16993, July 26, 2021., 2021
Späte Modifizierungen sind unerlässlich für die Diversifizierung von Verbindungen in der Synthese. Da Enzyme effiziente Werkzeuge für milde, Katalysator‐kontrollierte Funktionalisierungen bieten, sind neue biokatalytische Methoden für eine große Fülle orthogonaler Reaktionen entstanden.
Elvira Romero, Bethan S. Jones, Bethany N. Hogg, Arnau Rué Casamajo, Martin A. Hayes, Sabine L. Flitsch, Nicholas J. Turner, Christian Schnepel   +7 more
wiley   +1 more source

Enzymatic Late‐Stage Modifications: Better Late Than Never

Angewandte Chemie International Edition, Volume 60, Issue 31, Page 16824-16855, July 26, 2021., 2021
Late‐stage modification is an indispensable approach for compound diversification in synthesis. Since enzymes offer particularly powerful means for mild, catalyst‐controlled functionalisations, in recent years several novel biocatalytic methods have emerged enabling a broad array of orthogonal reactions.
Elvira Romero, Bethan S. Jones, Bethany N. Hogg, Arnau Rué Casamajo, Martin A. Hayes, Sabine L. Flitsch, Nicholas J. Turner, Christian Schnepel   +7 more
wiley   +1 more source

Cembrene Diterpenoids with Ether Linkages from Sarcophyton ehrenbergi: An Anti-Proliferation and Molecular-Docking Assessment

Marine Drugs, 2017
Three new cembrene diterpenoids, sarcoehrenbergilid A–C (1–3), along with four known diterpenoids, sarcophine (4), (+)-7α,8β-dihydroxydeepoxysarcophine (5), sinulolide A (6), and sinulolide B (7), and one steroid, sardisterol (8), were isolated and ...
Mohamed-Elamir F. Hegazy, Abdelsamed I. Elshamy, Tarik A. Mohamed, Ahmed R. Hamed, Mahmoud A. A. Ibrahim, Shinji Ohta, Paul W. Paré   +6 more
doaj   +1 more source

Klyflaccilins B‐T, Polyoxgenated Eunicellins from the Soft Coral Klyxum flaccidum

European Journal of Organic Chemistry, Volume 2021, Issue 9, Page 1402-1406, March 5, 2021., 2021
Nineteen new eunicellin diterpenoids named klyflaccilins B‐T were isolated from the gorgonian Klyxum flaccidum. The structures were elucidated by NMR, showing that they represent different eunicellin subclasses. For five compounds X‐ray crystal structures were obtained that allowed to determine their absolute configurations.
Geng Li, Li‐Li Sun, Jeroen S. Dickschat, Yue‐Wei Guo   +3 more
wiley   +1 more source

New Cembrane-Type Diterpenoids from the South China Sea Soft Coral Sarcophyton ehrenbergi

Molecules, 2016
Chemical investigation on the soft coral Sarcophyton ehrenbergi collected from the Xisha Islands of the South China Sea have led to the isolation of eight cembranoids including five new ones, sarcophytonoxides A–E (1–5). The structures of new cembranoids
Gui-Hua Tang, Zhang-Hua Sun, Yi-Hong Zou, Sheng Yin   +3 more
doaj   +1 more source

Uprolides N, O and P from the Panamanian Octocoral Eunicea succinea. [PDF]

, 2016
Three new diterpenes, uprolide N (1), uprolide O (2), uprolide P (3) and a known one, dolabellane (4), were isolated from the CH₂Cl₂-MeOH extract of the gorgonian octocoral Eunicea succinea, collected from Bocas del Toro, on the Caribbean coast of Panama.
Fernandez, Patricia L, Gerwick, William H, González, Yisett, Gutiérrez, Marcelino, Guzmán, Héctor M, Gómez-Reyes, José Félix, López-Perez, José Luis, Torres-Mendoza, Daniel   +7 more
core   +2 more sources

Comprehensive study on the effects of various stressors on soft corals and zooxanthellae [PDF]

, 2023
Soft corals have a remarkable potential as producer of secondary metabolites. However, they are vulnerable to changes in environment. Coral produce secondary metabolites as chemical defense against predators and environmental changes. In this thesis, the
Rahaweman, Ayu Christien
core   +1 more source