Results 11 to 20 of about 2,389 (219)

KDM6B-Mediated HADHA Demethylation/Lactylation Regulates Cementogenesis. [PDF]

J Dent Res
Cementum, a bone-like tissue, is an essential component of periodontium, and periodontitis can lead to degenerative changes in the cementum, eventually resulting in tooth loss. The therapeutic strategy for advanced periodontitis is to achieve periodontal
Yang Z, Wang H, Xiao J, Yang Q, Sun J, Liu H, Ma L, Huang X, Wang C, Wang X, Cao Z.   +10 more
europepmc   +6 more sources

A Reciprocal Interaction between β-Catenin and Osterix in Cementogenesis

Scientific Reports, 2017
Although accumulating evidence indicates that both β-catenin and osterix (Osx) are essential for bone and tooth development, few studies have investigated the interaction of these two key proteins in the context of cementogenesis.
Hwajung Choi, Tak-Heun Kim, Siqin Yang, Jeong-Chae Lee, Hyung-Keun You, Eui-Sic Cho   +5 more
doaj   +5 more sources

Kdm6b/Pdk1 Glycolytic Pathway-Driven Zeb2 Lactylation Promotes Cementogenesis

International Dental Journal
Aim or purpose: This study investigates the role of KDM6B-mediated glycolytic reprogramming in cementum regeneration, addressing the unclear mechanisms linking epigenetic-metabolic crosstalk to cementoblast mineralization.
Wang Xiaoxuan, Wang Huiyi, Yang Zhengkun, Cao Zhengguo   +3 more
doaj   +4 more sources

Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis [PDF]

International Journal of Oral Science, 2014
Cementum is critical for anchoring the insertion of periodontal ligament fibers to the tooth root. Several aspects of cementogenesis remain unclear, including differences between acellular cementum and cellular cementum, and between cementum and bone ...
Laura E. Zweifler, Mudita K Patel, Francisco Humberto Nociti, H.F. Wimer, José Luís Millán, Martha J. Somerman, Brian L. Foster   +6 more
core   +8 more sources

Intermittent parathyroid hormone (PTH) promotes cementogenesis and alleviates the catabolic effects of mechanical strain in cementoblasts [PDF]

BMC Cell Biology, 2017
Background External root resorption, commonly starting from cementum, is a severe side effect of orthodontic treatment. In this pathological process and repairing course followed, cementoblasts play a significant role.
Yuyu Li, Zhiai Hu, Chenchen Zhou, Yang Xu, Li Huang, Xin Wang, Shujuan Zou   +6 more
doaj   +3 more sources

Cementogenesis is inhibited under a mechanical static compressive force via Piezo1

The Angle Orthodontist, 2017
OBJECTIVE To investigate whether Piezo1, a mechanotransduction gene mediates the cementogenic activity of cementoblasts under a static mechanical compressive force. MATERIALS AND METHODS Murine cementoblasts (OCCM-30) were exposed to a 2.0 g/cm2 static
Yingying Zhang, Yiping Huang, Huaxiang Zhao, Ting Zhang, Feng Chen, Yan Liu   +5 more
semanticscholar   +4 more sources

Genetic and pharmacologic modulation of cementogenesis via pyrophosphate regulators

Bone, 2020
Pyrophosphate (PPi) serves as a potent and physiologically important regulator of mineralization, with systemic and local concentrations determined by several key regulators, including: tissue-nonspecific alkaline phosphatase (ALPL gene; TNAP protein), the progressive ankylosis protein (ANKH; ANK), and ectonucleotide pyrophosphatase/phosphodiesterase 1
Emily Y. Chu, Tam Vo, M.B. Chavez, Atsuhiro Nagasaki, Edward L. Mertz, Francisco Humberto Nociti, Sarah F. Aitken, Dillon Kavanagh, Kristin M. Zimmerman, Xiaofeng Li, Paul R. Stabach, Demetrios T. Braddock, José Luís Millán, Brian L. Foster, Martha J. Somerman   +14 more
semanticscholar   +6 more sources

Hertwig’s Epithelial Root Sheath Fate during Initial Cellular Cementogenesis in Rat Molars

Acta Histochemica et Cytochemica, 2015
To elucidate the fate of the epithelial root sheath during initial cellular cementogenesis, we examined developing maxillary first molars of rats by immunohistochemistry for keratin, vimentin, and tissue non-specific alkaline phosphatase (TNALP) and by ...
Tsuneyuki Yamamoto, Tamaki Yamada, Tomomaya Yamamoto, Tomoka Hasegawa, Hiromi Hongo, Kimimitsu Oda, Norio Amizuka   +6 more
semanticscholar   +6 more sources

Genetic evidence for the vital function of osterix in cementogenesis [PDF]

Journal of Bone and Mineral Research, 2012
Abstract To date, attempts to regenerate a complete tooth, including the critical periodontal tissues associated with the tooth root, have not been successful. Controversy still exists regarding the origin of the cell source for cellular cementum (epithelial or mesenchymal).
Zhengguo Cao, Hua Zhang, Xin Zhou, Xianglong Han, Yinshi Ren, Tian Gao, Yin Xiao, Benoît De Crombrugghe, Martha J. Somerman, Jian Q. Feng   +9 more
semanticscholar   +5 more sources

A Biphasic Feature of Gli1⁺-Mesenchymal Progenitors during Cementogenesis That Is Positively Controlled by Wnt/β-Catenin Signaling

Journal of dentistry research, 2021
Cementum, a specialized bony layer covering an entire molar root surface, anchors teeth into alveolar bone. Gli1, a key transcriptional activator in Hedgehog signaling, has been identified as a mesenchymal progenitor cell marker in various tissues ...
Xie Xiao-dong, Chunmei Xu, Hu Zhao, Jun Wang, Jian Q. Feng   +4 more
openalex   +3 more sources