LITTIP/Lgr6/HnRNPK complex regulates cementogenesis via Wnt signaling [PDF]
International Journal of Oral Science, 2023 Orthodontically induced tooth root resorption (OIRR) is a serious complication during orthodontic treatment. Stimulating cementum repair is the fundamental approach for the treatment of OIRR.
Tiancheng Li +9 more
doaj +4 more sources
CXXC5 mitigates P. gingivalis-inhibited cementogenesis by influencing mitochondrial biogenesis [PDF]
Cell Communication and Signaling, 2023 Background Cementoblasts on the tooth-root surface are responsible for cementum formation (cementogenesis) and sensitive to Porphyromonas gingivalis stimulation.
Li Ma +7 more
doaj +4 more sources
Periodontal regeneration: Lessons from the periodontal ligament-cementum junction in diverse animal models [PDF]
Frontiers in Dental Medicine, 2023 The attachment of the roots of mammalian teeth of limited eruption to the jawbone is reliant in part on the mineralization of collagen fibrils of the periodontal ligament (PDL) at their entry into bone and cementum as Sharpey's fibers.
Eli D. Sone +3 more
doaj +2 more sources
Bone Research, 2022 Periodontal ligament stem cells (PDLSCs) are a key cell type for restoring/regenerating lost/damaged periodontal tissues, including alveolar bone, periodontal ligament and root cementum, the latter of which is important for regaining tooth function ...
Daokun Deng, Xiao-Tao He, Fa-Ming Chen
exaly +2 more sources
Connective tissue growth factor promotes cementogenesis and cementum repair via Cx43/β-catenin axis [PDF]
Stem Cell Research & Therapy, 2022 Background Orthodontic tooth movement inevitably induces cementum resorption, which is an urgent problem for orthodontists to confront. Human periodontal ligament stem cells (hPDLSCs) exert an important role in the orthodontic tooth movement and exhibit ...
Zuping Wu +8 more
doaj +2 more sources
KDM6B/Pdk1 glycolytic pathway-driven ZEB2 lactylation promotes cellular cementum formation [PDF]
International Journal of Oral SciencePeriodontitis is a common chronic inflammatory disease that ultimately results in irreversible tooth loss. Cementum, a bone-like tissue surrounding tooth roots, deteriorates as periodontitis advances, ultimately causing tooth loss.
Zhengkun Yang +11 more
doaj +2 more sources
Combination of Periodontal Ligament Stem Cells and Metformin via Organic Cation Transporters for Periodontal Regeneration in Rats [PDF]
BiomoleculesPeriodontal regeneration remains challenging due to individual variability, especially in treatments involving bioactive factors such as metformin.
Qingchen Qiao +9 more
doaj +2 more sources
Evaluating the role of a novel homeodomain protein in periodontal regenerative therapy: An in-vitro study [PDF]
Journal of Oral Biology and Craniofacial ResearchIntroduction: The goal of periodontal treatment is to halt disease progression and restore the structure and function of damaged periodontal tissues.
Bhavya Shetty +5 more
doaj +2 more sources
Bone Morphogenetic Protein 7 Promotes the Differentiation of Periodontal Ligament Fibroblasts into F-Spondin-Expressing Cementoblast-like Cells During Root Canal Treatment—An In Vivo Rat Pulpectomy Model and In Vitro Human Fibroblast Study [PDF]
Dentistry JournalBackground/Objectives: The optimal healing process following root canal treatment involves biological apical sealing through new cementum formation.
Hiroki Iwasawa +5 more
doaj +2 more sources
Nanosilicates facilitate periodontal regeneration potential by activating the PI3K-AKT signaling pathway in periodontal ligament cells [PDF]
Journal of NanobiotechnologyThe recent development of nanobiomaterials has shed some light on the field of periodontal tissue regeneration. Laponite (LAP), an artificially synthesized two-dimensional (2D) disk-shaped nanosilicate, has garnered substantial attention in regenerative ...
Ziqin Chen +9 more
doaj +2 more sources