Results 61 to 70 of about 2,867,234 (274)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

The radical of the focal values ideal of the complex Kukles system

Журнал Белорусского государственного университета: Математика, информатика, 2018
In the article it is considered the center-focus problem for complex Kukles system x = y, y = -x + Ax2 + 3Bxy + Cy2 + Kx3 + 3Lx2y + Mxy2 + Ny3. The problem is solved by the new method, obtained by A. P.
Anton P. Sadovskii, Tatsiana V. Makavetskaya, Dmitry N. Cherginets   +2 more
doaj  

Center problem for quartic differential systems with an affine invariant straight line of maximal multiplicity

Acta et Commentationes: Ştiinţe Exacte şi ale Naturii
In this paper the quartic differential systems with a center-focus critical point and non-degenerate infinity are examined. We show that in this family the maximal multiplicity of an affine invariant straight line is six. Modulo the affine transformation
Olga Vacaraș
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

An Abel type cubic system

Electronic Journal of Differential Equations, 2015
We consider center conditions for plane polynomial systems of Abel type consisting of a linear center perturbed by the sum of 2 homogeneous polynomials of degrees n and 2n-1 where $n \ge 2$.
Gary R. Nicklason
doaj  

THE IMAGE SPEED DURING THE OPTICAL-ELECTRONIC SURFACING THE PLANET

Российский технологический журнал, 2018
In this paper, a formula is obtained for calculating the velocity of an image in the plane of image fixation during a space survey of the planet's surface with the aid of an on-oard optoelectronic device.
V. Ya. Gecha, M. Yu. Zhilenev, V. B. Fyodorov, D. A. Khrychev, Yu. I. Khudak, A. V. Shatina   +5 more
doaj   +1 more source

THE CENTER-FOCUS PROBLEM AND BIFURCATION OF LIMIT CYCLES IN A CLASS OF 7TH-DEGREE POLYNOMIAL SYSTEMS

Journal of Applied Analysis & Computation, 2016
Summary: By computing singular point values, the center conditions are established for a class of 7th-degree planar polynomial systems with 15 parameters. It is proved that such systems can have 13 small-amplitude limit cycles in the neighborhood of the origin.
Sang, Bo, Wang, Qinlong
openaire   +2 more sources

Dynamics of vortex dipoles in anisotropic Bose-Einstein condensates

, 2015
We study the motion of a vortex dipole in a Bose-Einstein condensate confined to an anisotropic trap. We focus on a system of ordinary differential equations describing the vortices' motion, which is in turn a reduced model of the Gross-Pitaevskii ...
Carretero-Gonzalez, Ricardo, Goodman, Roy H., Kevrekidis, Panayotis G.   +2 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source