Results 61 to 70 of about 306,199 (304)
Religions, 2021 In ancient Mesopotamia, the functions of the temple were manifold. It could operate as an administrative center, as a center of learning, as a place of jurisdiction, as a center for healing, and as an economic institution, as indicated in both textual ...
Beate Pongratz-Leisten
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Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
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Split Attractor Flow in N=2 Minimally Coupled Supergravity
, 2010 We classify the stability region, marginal stability walls (MS) and split attractor flows for two-center extremal black holes in four-dimensional N=2 supergravity minimally coupled to n vector multiplets.
Alessio Marrani +45 more
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Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
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Hair in the Back of a Throat: Non-Supersymmetric Multi-Center Solutions from K\"ahler Manifolds
, 2011 We find a class of non-supersymmetric multi-center solutions of the STU model of five-dimensional ungauged supergravity. The solutions are determined by a system of linear equations defined on a four-dimensional K\"ahler manifold with vanishing Ricci ...
Bobev, Nikolay +2 more
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Complexity, 2021 In this paper, a diffusion two-phytoplankton one-zooplankton model with time delay, Beddington–DeAnglis functional response, and Holling II functional response is proposed.
Xin-You Meng, Li Xiao
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Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
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Center manifold and exponentially-bounded solutions of a forced Newtonian system with dissipation
Electronic Journal of Differential Equations, 2000 We study the existence of exponentially-bounded solutions to the following system of second-order ordinary differential equations with dissipation: $$ u''+cu'+Au+kH(u) = P(t), quad u in {mathbb R}^n, quad t in {mathbb R}, $$ where $c$ and $k$ are ...
Luis Garcia, Hugo Leiva
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A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
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Моделирование и анализ информационных систем, 2014 In this paper, we study the asymptotic integration problem in the neighborhood of infinity for a certain class of linear functional differential systems. We construct the asymptotics for solutions of the considered systems in the critical case. Using the
P. N. Nesterov
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