Potential therapeutic targeting of BKCa channels in glioblastoma treatment
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Using an Incidental Separated Segment of the Socket Wall as an Autogenous Block: A Lesson Learned Case Report of Three-Dimensional Bone Reconstruction in the Anterior Maxilla. [PDF]
Ekhlasmandkermani M +3 more
europepmc +1 more source
Utilizaçao da variável diâmetro quadrático médio (dq2), em estimativas volumétricas de Eucalyptus grandis Hill ex-Maiden, na Regiao Central do Paraná [PDF]
Décio José de Figueiredo
openalex
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
The hourglass of high acuity vision: Cone plasticity at the intersection of time and space shapes the foveola. [PDF]
Housset M, Cayouette M.
europepmc +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Teaching and learning Spanish in primary and early secondary schools in west central Scotland
Lore Gallastegi
openalex +2 more sources

