Results 101 to 110 of about 7,515,240 (216)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Central America’s Maras: Public policies and best practices

Revista CIDOB d'Afers Internacionals, 2008
In recent years, youth gangs in Central America have become a significant focus of great attention, both in the region itself and in the United States. Nevertheless, there is a general lack of understanding as to who they are, why they form and how best ...
Elsa Falkenburger, Geoff Thale
doaj  

Overseas Relief (ASF AR 1, Box 1, Folder 13)

, 1948
Digital ImageDigital finding aid ...
Central Sephardic Jewish Community of America
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Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

New record of Clypeasterophilus stebbingi (Rathbun, 1918) (Decapoda: Brachyura: Pinnotheridae) from the east coast of Nicaragua

Nauplius
The pinnotherid crab Clypeasterophilus stebbingi (Rathbun, 1918), previously known from Florida, USA, Colombia and Brazil, is reported for the first time from Central America, on the east coast of Nicaragua.
Michel E. Hendrickx, Francisco Solis
doaj  

Immigration (ASF AR 1, Box 1, Folder 5)

, 1948
Digital ImageDigital finding aid ...
Central Sephardic Jewish Community of America
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Letters of Recommendation, Dr. Alcalay (ASF AR 1, Box 1, Folder 9)

, 1946
Digital ImageDigital finding aid ...
Central Sephardic Jewish Community of America
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Stadium or Bridge : A Note on the Diplomatic Rivalry between China and Taiwan in Central America [PDF]

, 2018
Panama broke diplomatic ties with Taiwan to establish those with China in June 2017, 10 years after Costa Rica did so, leaving only 19 countries plus the Vatican that still recognize offi cially Taiwan. Many such countries are located in Central America,
9000008025284, 早川, 達二, 46395
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