Results 101 to 110 of about 403,157 (288)

13C-assisted metabolic flux analysis to investigate heterotrophic and mixotrophic metabolism in Cupriavidus necator H16 [PDF]

, 2018
Introduction. Cupriavidus necator H16 is a gram-negative bacterium, capable of lithoautotrophic growth by utilizing hydrogen as an energy source and fixing carbon dioxide (CO2) through Calvin-Benson-Bassham (CBB) cycle. The potential to utilize synthesis
A Pohlmann, A Steinbüchel, B Bowien, B Christensen, C Wittmann, CG Friedrich, CH Poskar, CJ Brigham, E Schwartz, E Schwartz, E Wilde, HG Schlegel, HG Schlegel, JD Young, JL Ienczak, JM Park, K Peplinski, K Walsh, K-H Tang, L Stryer, LE Quek, M Lopar, M Raberg, M Weitzel, MR Antoniewicz, N Bruland, N Tanadchangsaeng, N Zamboni, N Zamboni, Naglis Malys, Nigel P. Minton, P Millard, R Shimizu, R Shimizu, S Alagesan, Swathi Alagesan, T Fukui, W Wiechert, W Wiechert, X Feng   +39 more
core   +2 more sources

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

The CreC regulator of Escherichia coli, a new target for metabolic manipulations [PDF]

, 2015
The CreBC (carbon source-responsive) two-component regulation system of Escherichia coli affects a number of functions, including intermediary carbon catabolism.
Cabrera Gomez, José Gregorio, Godoy, Manuel Santiago, Nikel, Pablo Ivan, Pettinari, María Julia   +3 more
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Central Carbon Metabolic Pathways in Streptomyces

, 2011
Streptomyces and other actinomycetes are fascinating soil bacteria of major economic importance. They produce 70% of antibiotics known to man and numerous other pharmaceuticals for treatment of, e.g. cancer, a range of infections, high cholesterol, or have immunosuppressive activity. It is not surprising that the multitude of gene clusters encoding for
van Keulen, Geertje, Siebring, Jeroen, Dijkhuizen, Lubbert   +2 more
openaire   +3 more sources

Creating metabolic demand as an engineering strategy in Pseudomonas putida – Rhamnolipid synthesis as an example

Metabolic Engineering Communications, 2016
Metabolic engineering of microbial cell factories for the production of heterologous secondary metabolites implicitly relies on the intensification of intracellular flux directed toward the product of choice.
Till Tiso, Petra Sabelhaus, Beate Behrens, Andreas Wittgens, Frank Rosenau, Heiko Hayen, Lars Mathias Blank   +6 more
doaj   +1 more source

Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development [PDF]

, 2011
<p>Background: Plasmodium falciparum contains three genes encoding potential glutamate dehydrogenases. The protein encoded by gdha has previously been biochemically and structurally characterized.
Aparicio, I., Engel, P.C., Llinas, M., Muller, S., Olszewski, K., Patzewitz, E.-M., Perner, J., Storm, J.   +7 more
core   +4 more sources

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

CceR and AkgR Regulate Central Carbon and Energy Metabolism in Alphaproteobacteria

mBio, 2015
Many pathways of carbon and energy metabolism are conserved across the phylogeny, but the networks that regulate their expression or activity often vary considerably among organisms. In this work, we show that two previously uncharacterized transcription
Saheed Imam, Daniel R. Noguera, Timothy J. Donohue   +2 more
doaj   +1 more source