Results 11 to 20 of about 403,157 (288)
Phenotypic bistability in Escherichia coli's central carbon metabolism
Molecular Systems Biology, 2014 Fluctuations in intracellular molecule abundance can lead to distinct, coexisting phenotypes in isogenic populations. Although metabolism continuously adapts to unpredictable environmental changes, and although bistability was found in certain substrate ...
Oliver Kotte +3 more
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Transcriptional regulation of central carbon metabolism in Pseudomonas aeruginosa [PDF]
Microbial Biotechnology, 2020 Summary Microbes such as Pseudomonas aeruginosa are often challenged by rapidly changing nutritional environments. In order to adapt to these shifts in nutrient availability, bacteria exert tight transcriptional control over the enzymes of central ...
Stephen K. Dolan +3 more
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The Central Carbon and Energy Metabolism of Marine Diatoms [PDF]
Metabolites, 2013 Diatoms are heterokont algae derived from a secondary symbiotic event in which a eukaryotic host cell acquired an eukaryotic red alga as plastid. The multiple endosymbiosis and horizontal gene transfer processes provide diatoms unusual opportunities for ...
Adriano Nunes-Nesi +2 more
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Regulation of Central Carbon and Amino Acid Metabolism in Plants [PDF]
Plants, 2021 Fluctuations in the prevailing environmental conditions, including light availability and intensity, CO2/O2 ratio, temperature, and nutrient or water supply, require rapid metabolic switches to maintain proper metabolism [...]
Stefan Timm, Stéphanie Arrivault
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Oxygen-Sensitive Remodeling of Central Carbon Metabolism by Archaic eIF5B [PDF]
Cell Reports, 2018 Summary: The eukaryotic translation initiation factor 5B (eIF5B) is a homolog of IF2, an ancient translation factor that enables initiator methionine-tRNAiMet (met-tRNAiMet) loading on prokaryotic ribosomes.
J.J. David Ho +5 more
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Advances in the optimization of central carbon metabolism in metabolic engineering. [PDF]
Microb Cell Fact, 2023 AbstractCentral carbon metabolism (CCM), including glycolysis, tricarboxylic acid cycle and the pentose phosphate pathway, is the most fundamental metabolic process in the activities of living organisms that maintains normal cellular growth. CCM has been widely used in microbial metabolic engineering in recent years due to its unique regulatory role in
Wu Z +7 more
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Targeting super-enhancers reprograms glioblastoma central carbon metabolism. [PDF]
Oncotarget, 2021 The concept that tumor cells demand a distinct form of metabolism was appreciated almost a century ago when the German biochemist Otto Warburg realized that tumor cells heavily utilize glucose and produce lactic acid while relatively reducing oxidative metabolism.
Nguyen TTT +3 more
europepmc +4 more sources
Chimeric origins and dynamic evolution of central carbon metabolism in eukaryotes. [PDF]
Nat Ecol EvolThe origin of eukaryotes was a key event in the history of life. Current leading hypotheses propose that a symbiosis between an asgardarchaeal host cell and an alphaproteobacterial endosymbiont represented a crucial step in eukaryotic origins and invoke a central role for syntrophic interactions - that is, metabolic cross-feeding between the partners ...
Santana-Molina C +3 more
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Central carbon metabolism of Plasmodium parasites [PDF]
Molecular and Biochemical Parasitology, 2011 The central role of metabolic perturbation to the pathology of malaria, the promise of antimetabolites as antimalarial drugs and a basic scientific interest in understanding this fascinating example of highly divergent microbial metabolism has spurred a major and concerted research effort towards elucidating the metabolic network of the Plasmodium ...
Kellen L, Olszewski, Manuel, Llinás
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Metabolic plasticity of central carbon metabolism protects mycobacteria [PDF]
Proceedings of the National Academy of Sciences, 2015 Central carbon metabolism (CCM) that transforms carbon through glycolysis, gluconeogenesis, the pentose phosphate pathway, and the TCA pathway into energy is essential for the physiology of Mycobacterium tuberculosis (Mtb). In contrast to other pathogens, humans are the only known reservoir of Mtb, where it mainly resides in macrophages of the primary ...
Bridgette M, Cumming, Adrie J C, Steyn
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