Results 41 to 50 of about 403,157 (288)

Mannogen-ing Central Carbon Metabolism by Leishmania

Trends in Parasitology, 2019
Leishmania parasites synthesize mannogens, a unique type of storage carbohydrate, from finely tuned interactions between synthesis and degradation by a family of mannosyltransferase/phosphorylases (MTPs) newly discovered by Sernee et al. The crucial roles of mannogen in regulating central carbon metabolism and in vivo virulence suggest the potential of
Kai, Zhang, Stephen M, Beverley
openaire   +3 more sources

Dynamic Metabolic Rewiring Enables Efficient Acetyl Coenzyme A Assimilation in Paracoccus denitrificans

mBio, 2019
During growth, microorganisms have to balance metabolic flux between energy and biosynthesis. One of the key intermediates in central carbon metabolism is acetyl coenzyme A (acetyl-CoA), which can be either oxidized in the citric acid cycle or ...
Katharina Kremer, Muriel C. F. van Teeseling, Lennart Schada von Borzyskowski, Iria Bernhardsgrütter, Rob J. M. van Spanning, Andrew J. Gates, Mitja N. P. Remus-Emsermann, Martin Thanbichler, Tobias J. Erb   +8 more
doaj   +1 more source

Central carbon metabolism ofLeishmaniaparasites

Parasitology, 2010
SUMMARYLeishmaniaspp. are sandfly-transmitted protozoa parasites that cause a spectrum of diseases in humans. Many enzymes involved inLeishmaniacentral carbon metabolism differ from their equivalents in the mammalian host and are potential drug targets.
Eleanor C, Saunders, David P, DE Souza, Thomas, Naderer, Marijke F, Sernee, Julie E, Ralton, Maria A, Doyle, James I, Macrae, Jenny L, Chambers, Joanne, Heng, Amsha, Nahid, Vladimir A, Likic, Malcolm J, McConville   +11 more
openaire   +2 more sources

Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier [PDF]

Trends in Microbiology, 2011
Recent advances in liquid chromatography and mass spectrometry have enabled the highly parallel, quantitative measurement of metabolites within a cell and the ability to trace their biochemical fates. In Mycobacterium tuberculosis (Mtb), these advances have highlighted major gaps in our understanding of central carbon metabolism (CCM) that have ...
Kyu Y, Rhee, Luiz Pedro Sorio, de Carvalho, Ruslana, Bryk, Sabine, Ehrt, Joeli, Marrero, Sae Woong, Park, Dirk, Schnappinger, Aditya, Venugopal, Carl, Nathan   +8 more
openaire   +2 more sources

Flor yeasts rewire the central carbon metabolism during wine alcoholic fermentation [PDF]

Frontiers in Fungal Biology, 2021
AbstractThe identification of natural allelic variations controlling quantitative traits could contribute to decipher metabolic adaptation mechanisms within different populations of the same species. Such variations could result from man-mediated selection pressures and participate to the domestication.
Emilien Peltier, Emilien Peltier, Emilien Peltier, Charlotte Vion, Charlotte Vion, Omar Abou Saada, Anne Friedrich, Joseph Schacherer, Philippe Marullo, Philippe Marullo   +9 more
openaire   +6 more sources

Central carbon metabolism in the progression of mammary carcinoma [PDF]

Breast Cancer Research and Treatment, 2007
There is a growing belief that the metabolic program of breast tumor cells could be a therapeutic target. Yet, without detailed information on central carbon metabolism in breast tumors it is impossible to know which metabolic pathways to target, and how their inhibition might influence different stages of breast tumor progression.
Richardson, Adam D., Yang, Chen, Osterman, Andrei, Smith, Jeffrey W.   +3 more
openaire   +2 more sources

The evolutionary rewiring of ubiquitination targets has reprogrammed the regulation of carbon assimilation in the pathogenic yeast Candida albicans [PDF]

, 2012
Date of Acceptance: 13/11/2012 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-ShareAlike 3.0 Unported license, which permits unrestricted noncommercial use, distribution, and reproduction in ...
Ashe, Atir-Lande, Barelle, Barford, Beckwith, Brown, Buchalter, Calderone, Carlson, Cline, Crabtree, de Nobel, Ene, Enjalbert, Enjalbert, Enjalbert, Entian, Fradin, Futcher, Gancedo, Gancedo, Gancedo, Garreau, Gounalaki, Gygi, Görner, Horak, Hämmerle, Ihmels, Imbeaud, Jacob, Janke, Jiang, Johnston, Kaniak, Knop, Kusch, Lavoie, Leach, Leach, Leng, Li, Lorenz, Lorenz, López-Boado, Martchenko, Mercado, Mercado, Mercado, Merico, Nantel, Niimi, Odds, Ozcan, Piekarska, Radivojac, Ramírez, Regelmann, Rodaki, Roig, Roig, Rolland, Sabina, Scheffler, Schüle, Sherman, Smith, Stanhill, Thevelein, Thewes, Trunk, Tsong, Ueno, Usaite, Walker, Yin, Yin, Yin, Yin   +78 more
core   +1 more source

Exogenous D-ribose promotes gentamicin treatment of several drug-resistant Salmonella

Frontiers in Microbiology, 2022
The metabolic microenvironment of bacteria impacts drug efficacy. However, the metabolic mechanisms of drug-resistant Salmonella spp. remain largely unknown. This study characterized the metabolic mechanism of gentamicin-resistant Salmonella Choleraesuis
Yanhong Zhou, Yanhong Zhou, Yan Yong, Chunyang Zhu, Chunyang Zhu, Heng Yang, Heng Yang, Binghu Fang, Binghu Fang   +8 more
doaj   +1 more source

Kinetic Modeling of Saccharomyces cerevisiae Central Carbon Metabolism: Achievements, Limitations, and Opportunities. [PDF]

Metabolites, 2022
Central carbon metabolism comprises the metabolic pathways in the cell that process nutrients into energy, building blocks and byproducts. To unravel the regulation of this network upon glucose perturbation, several metabolic models have been developed for the microorganism Saccharomyces cerevisiae.
Lao-Martil D, Verhagen KJA, Schmitz JPJ, Teusink B, Wahl SA, van Riel NAW.   +5 more
europepmc   +7 more sources

Remnants of an ancient metabolism without phosphate [PDF]

, 2017
Phosphate is essential for all living systems, serving as a building block of genetic and metabolic machinery. However, it is unclear how phosphate could have assumed these central roles on primordial Earth, given its poor geochemical accessibility.
Goldford, Joshua E., Hartman, Hyman, Segrè, Daniel, Smith, Temple F.   +3 more
core   +1 more source