Metabolic Dysfunction in Parkinson’s Disease: Bioenergetics, Redox Homeostasis and Central Carbon Metabolism [PDF]
Brain Research Bulletin, 2017 The loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and the accumulation of protein inclusions (Lewy bodies) are the pathological hallmarks of Parkinson's disease (PD). PD is triggered by genetic alterations, environmental/occupational exposures and aging.
Anandhan, Annadurai +7 more
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Incomplete Wood-Ljungdahl pathway facilitates one-carbon metabolism in organohalide-respiring Dehalococcoides mccartyi. [PDF]
, 2014 The acetyl-CoA "Wood-Ljungdahl" pathway couples the folate-mediated one-carbon (C1) metabolism to either CO2 reduction or acetate oxidation via acetyl-CoA.
Alvarez-Cohen, Lisa +8 more
core +1 more source
Nucleosides are overlooked fuels in central carbon metabolism [PDF]
Trends in Endocrinology & MetabolismFrom our daily nutrition and synthesis within cells, nucleosides enter the bloodstream and circulate throughout the body and tissues. Nucleosides and nucleotides are classically viewed as precursors of nucleic acids, but recently they have emerged as a novel energy source for central carbon metabolism.
Abigail Strefeler +2 more
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Prognostic Roles of Central Carbon Metabolism–Associated Genes in Patients With Low-Grade Glioma
Frontiers in Genetics, 2019 Purpose: Metabolic alterations are crucial for tumor progression and response to therapy. The comprehensive model of combined central carbon metabolism–associated genes that contribute to the outcomes of glioma and astrocytoma is not well understood ...
Li Wang, Meng Guo, Kai Wang, Lei Zhang
doaj +1 more source
Targeted proteome analysis of single-gene deletion strains of Saccharomyces cerevisiae lacking enzymes in the central carbon metabolism. [PDF]
PLoS ONE, 2017 Central carbon metabolism is controlled by modulating the protein abundance profiles of enzymes that maintain the essential systems in living organisms.
Fumio Matsuda +4 more
doaj +1 more source
Dinner date: Neisseria gonorrhoeae central carbon metabolism and pathogenesis. [PDF]
Emerg Top Life Sci, 2023 Neisseria gonorrhoeae, the causative agent of the sexually transmitted infection gonorrhea, is a human-adapted pathogen that does not productively infect other organisms. The ongoing relationship between N. gonorrhoeae and the human host is facilitated by the exchange of nutrient resources that allow for N. gonorrhoeae growth in the human genital tract.
Potter AD, Criss AK.
europepmc +3 more sources
Engineering microbial fatty acid metabolism for biofuels and biochemicals [PDF]
, 2017 Traditional oleochemical industry chemically processes animal fats and plant oils to produce detergents, lubricants, biodiesel, plastics, coatings, and other products.
Borodina, Irina +3 more
core +2 more sources
Post-translational regulation of metabolism in fumarate hydratase deficient cancer cells. [PDF]
, 2018 Deregulated signal transduction and energy metabolism are hallmarks of cancer and both play a fundamental role in tumorigenesis. While it is increasingly recognised that signalling and metabolism are highly interconnected, the underpinning mechanisms of ...
Costa, Ana SH +7 more
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Reprogramming of central carbon metabolism in cancer stem cells
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017 Cancer metabolism has been studied for years and adopted in the clinic for monitoring disease progression and therapy response. Despite our growing knowledge of a distinctly altered metabolic behavior in cancer, drugs targeting cancer metabolism have remained less than promising.
Wong, TL, CHE, N, Ma, SKY
openaire +4 more sources
Single nucleotide polymorphisms of one-carbon metabolism and cancers of the esophagus, stomach, and liver in a Chinese population. [PDF]
, 2014 One-carbon metabolism (folate metabolism) is considered important in carcinogenesis because of its involvement in DNA synthesis and biological methylation reactions.
Baecker, Aileen +13 more
core +4 more sources