Results 191 to 200 of about 759,357 (305)

Central composite design driven optimization of sustainable stability indicating HPLC method for the determination of Tigecycline and greenness assessment. [PDF]

F1000Res, 2023
Hafez HM, Barghash SS, Soliman MM, Soltan MK, Abd Elrahman M, Katamesh NS.   +5 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Heavy metal adsorption by graphene oxide modified with 5-amino-3(2-thienyl)pyrazole using central composite design/response surface methodology (CCD/RSM). [PDF]

RSC Adv
Alimohammady M, Jahangiri M, Salavati-Niasari M, Aljeboree AM.   +3 more
europepmc   +1 more source

Effective adsorption of amoxicillin by using UIO-66@ Cr-MIL-101 nanohybrid: isotherm, kinetic, thermodynamic, and optimization by central composite design. [PDF]

Sci Rep, 2023
Sharafinia S, Rashidi A, Tabarkhoon F, Dehghan F, Tabarkhoon F, Bazmi M.   +5 more
europepmc   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Optimized production of bacterioruberin from "Haloferax marinum" using one-factor-at-a-time and central composite design approaches. [PDF]

Bioresour Bioprocess
Cho ES, Hwang CY, Seo MJ.
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Synergistic effects and optimization of cement kiln dust and glass powder incorporation in self compacting mortar using central composite design. [PDF]

Sci Rep
Hammouche R, Belebchouche C, Hammoudi A, Douadi A, Hebbache K, Boutlikht M, Berkouche A, Khishe M.   +7 more
europepmc   +1 more source

Enhancing docosahexaenoic acid production of Schizochytrium sp. by optimizing fermentation using central composite design. [PDF]

BMC Biotechnol, 2022
Ding J, Fu Z, Zhu Y, He J, Ma L, Bu D.
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source