Results 31 to 40 of about 3,481 (110)

Targeting Orexin 2 Receptors in Idiopathic Hypersomnia and Narcolepsy: A Randomised Phase 1b Proof‐Of‐Concept Study of Alixorexton

Journal of Sleep Research, EarlyView.
Orexin 2 receptor agonists have demonstrated that targeting the orexin system may address symptoms of central disorders of hypersomnolence. Results of this phase 1 study support the phase 2 clinical evaluation of oral alixorexton in patients with IH, NT2 and NT1.
Ronald R. Grunstein, Brendon J. Yee, Julia L. Chapman, Jian Eu Tai, Sheila Sivam, Craig Hopkinson, Daniel G. Smith, Alexandra Lovett, Shifang Liu, Sergey Yagoda, Bhaskar Rege   +10 more
wiley   +1 more source

The diagnostic value of sleep and vigilance tests in central disorders of hypersomnolence

Sleep, 2022
AbstractStudy ObjectivesThis retrospective cross-sectional observational study explored the diagnostic value of selected sleep and vigilance tests (SVT) beyond the multiple sleep latency test to differentiate between various central disorders of hypersomnolence (CDH) and fatigue syndromes.MethodsData from patients who underwent the multiple sleep ...
Johannes Mathis, Daniel Andres, Wolfgang J Schmitt, Claudio L Bassetti, Christian W Hess, David R Schreier   +5 more
openaire   +2 more sources

Comparison of Actigraphy and Polysomnography in a Sleep Centre Cohort

Journal of Sleep Research, EarlyView.
MotionWatch 8 actigraphy correlated most strongly with PSG for total sleep time and showed modest group‐level bias, but wide individual limits of agreement precluded interchangeability. PLMS modified actigraphy‐PSG differences, while recording setting influenced actigraphy‐derived sleep continuity across home and inpatient recordings.
Panagis Drakatos, Iain Duncan, Laura Pérez‐Carbonell, Abidemi I. Otaiku, Fotis Kapsimalis, Sean Higgins, Meir H. Kryger, Adrian J. Williams, Guy D. Leschziner   +8 more
wiley   +1 more source

Phenotypic Variability in Slow‐Wave Sleep in Depression: Associations With Clinical Profiles and Disorder Severity

Journal of Sleep Research, Volume 35, Issue 5, October 2026.
ABSTRACT Slow‐wave sleep (SWS; stage N3) is often reported as reduced in depression, yet variability across depressive phenotypes remains poorly characterised. This study aimed to determine whether N3 architecture—proportion, duration, and latency—identifies clinically distinct profiles in major depressive episode (MDE).
Antoine Salmeron, Pierre A. Geoffroy, Lily Vissouze, Jeanne Leseur, Heloise Rach, Michel Lejoyeux, Justine Frija, Marie Pia d’Ortho, Julia Maruani   +8 more
wiley   +1 more source

Slow Wave Activity During Nocturnal Sleep in Hypersomnolence Disorder

Journal of Sleep Research, Volume 35, Issue 5, October 2026.
ABSTRACT Slow waves during non‐rapid eye movement (NREM) sleep are associated with the restorative aspects of sleep. Previous research has suggested reduced normalized slow wave activity (SWA), particularly in the first cycle of NREM sleep, as a feature of hypersomnolence disorder (HD); however, the scarcity of existing research highlights the need for
Jesse D. Cook, Brady A. Riedner, Meredith E. Rumble, Michael R. Goldstein, Ana Maria Vascan, Kieulinh M. Tran, David T. Plante   +6 more
wiley   +1 more source

Diagnostic Value of Psychomotor Vigilance Task for Severe Sleep Inertia in Idiopathic Hypersomnia Versus Other Sleep Disorders Without Sleep Inertia

Journal of Sleep Research, Volume 35, Issue 5, October 2026.
Diagnostic Value of PVT for Severe Sleep Inertia in Idiopathic Hypersomnia. ABSTRACT Sleep inertia impairs performance upon awakening and may be assessed using the psychomotor vigilance task (PVT). This study aimed to determine optimal PVT lapse cut‐offs at awakening to objectively measure sleep inertia by comparing patients with idiopathic hypersomnia
Elisa Evangelista, Alexandre Derré, Lucie Barateau, Anna Laura Rassu, Sofiene Chenini, Isabelle Jaussent, Yves Dauvilliers   +6 more
wiley   +1 more source

What Do Patient‐Reported Sleep Measures Assess? A Content Analysis

Journal of Sleep Research, Volume 35, Issue 5, October 2026.
ABSTRACT Current systematic review analysed the content of generic patient‐reported sleep measures (PRSMs) using (1) the International Classification of Functioning, Disability and Health (ICF) and (2) semantic analysis. A literature search identified 27 PRSMs applicable across multiple sleep disorders.
Marie De Bruecker, Elke Veirman, An Mariman, Dirk A. Pevernagie, Katrien B. C. Hertegonne, Fré A. Bauters, Dimitri M. L. Van Ryckeghem, Geert Crombez   +7 more
wiley   +1 more source

Whole‐Night Gentle Rocking Improves Sleep in Poor Sleepers With Insomnia Complaints

Journal of Sleep Research, Volume 35, Issue 5, October 2026.
ABSTRACT Specific brain oscillations can be manipulated during sleep to improve sleep quality and memory performance. We previously demonstrated that continuous rocking stimulation (0.25 Hz, lateral movement) applied to good sleepers during sleep enhanced stable deep sleep, boosted NREM oscillations (spindles and slow waves) and memory consolidation ...
Aurore A. Perrault, Nathan E. Cross, Thien Thanh Dang Vu, Sophie Schwartz, Laurence Bayer   +4 more
wiley   +1 more source

The Development of the European Sleep Questionnaire A New Patient‐Reported Outcome Measure

Journal of Sleep Research, Volume 35, Issue 5, October 2026.
ABSTRACT Sleep medicine relies on patient‐reported outcome measures (PROMs) to complement clinical interviews and objective sleep tests. Available sleep questionnaires focus on isolated symptoms or single disorders, limiting their ability to capture the complexity of sleep conditions. Also, many PROMs remain poorly validated.
Dirk A. Pevernagie, Marie De Bruecker, Elke Veirman, Geert Crombez, Dimitri M. L. Van Ryckeghem, Katrien Hertegonne, Fré A. Bauters, Inger L. Abma, Erna Sif Arnardottir, Ludger Grote, Jan Hedner, Anna Sigridur. Islind, Kamilla Rún Jóhannsdóttir, Gert Jan Lammers, Walter T. McNicholas, Piet‐Heijn van Mechelen, Kristín Anna Ólafsdóttir, Sebastiaan Overeem, Dieter Riemann, Reijo Sund, An Mariman   +20 more
wiley   +1 more source

FXTAS and the Spectrum of FMR1 Premutation‐Associated Phenotypes in Latin America: A Scoping Review

Movement Disorders Clinical Practice, Volume 13, Issue 9, Page 2045-2058, September 2026.
Abstract Background Fragile X–associated tremor/ataxia syndrome (FXTAS) is a late‐onset neurodegenerative disorder caused by FMR1 premutation expansions (55–200 CGG repeats). Although well described in populations of predominantly European ancestry, FXTAS remains poorly characterized in Latin America due to limited awareness, restricted access to ...
Amy Schmidmajer, Salomón Páez‐García, Santiago Martínez, Jacobo Ramírez‐Triana, Kevin O'Hara‐Veintimilla, Andrés Ricaurte‐Fajardo, Catalina Cerquera‐Cleves   +6 more
wiley   +1 more source